Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-naphthalenylmethyl Derivatives of Uracil and Their Analogues As Probable Inhibitors of Human Cytomegalovirus Replication.

Autor: Paramonova MP; Volgograd State Medical University, Volgograd, Russia., Gureeva ES; Volgograd State Medical University, Volgograd, Russia., Ozerov AA; Volgograd State Medical University, Volgograd, Russia., Snoeck R; Rega Institute for Medical Research, KU Leuven, Leuven B-3000, Belgium., Andrei G; Rega Institute for Medical Research, KU Leuven, Leuven B-3000, Belgium., Aleksandrov DA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Khandazhinskaya AL; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. khandazhinskaya@bk.ru., Novikov MS; Volgograd State Medical University, Volgograd, Russia., Kochetkov SN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. snk1952@gmail.com.

Publikováno v: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2023 Apr; Vol. 509 (1), pp. 41-46. Date of Electronic Publication: 2023 Jun 20.

Antiviral Activity of N 1 ,N 3 -Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of Concern.

Autor: Siniavin AE; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Molecular Neuroimmune Signalling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Novikov MS; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, 400131 Volgograd, Russia., Gushchin VA; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Virology, Lomonosov Moscow State University, 119991 Moscow, Russia., Terechov AA; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Ivanov IA; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Molecular Neuroimmune Signalling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Paramonova MP; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, 400131 Volgograd, Russia., Gureeva ES; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, 400131 Volgograd, Russia., Russu LI; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Kuznetsova NA; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Shidlovskaya EV; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Luyksaar SI; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Vasina DV; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Zolotov SA; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Zigangirova NA; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Logunov DY; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Gintsburg AL; N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ivanovsky Institute of Virology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Infectiology and Virology, Federal State Autonomous Educational Institution of Higher Education I M Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119435 Moscow, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 05; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 05.

Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives.

Autor: Paramonova MP; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Volgograd, 400131 Russia., Khandazhinskaya AL; Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, 119991 Russia., Ozerov AA; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Volgograd, 400131 Russia., Kochetkov SN; Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, 119991 Russia., Snoeck R; Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium., Andrei G; Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium., Novikov MS; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Volgograd, 400131 Russia.

Publikováno v: Acta naturae [Acta Naturae] 2020 Jul-Sep; Vol. 12 (3), pp. 134-139.

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs.

Autor: Babkov DA; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia., Valuev-Elliston VT; Engelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str., 32, Moscow 119991, Russia., Paramonova MP; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia., Ozerov AA; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia., Ivanov AV; Engelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str., 32, Moscow 119991, Russia., Chizhov AO; Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Leninsky pr., 47, Moscow 119991, Russia., Khandazhinskaya AL; Engelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str., 32, Moscow 119991, Russia., Kochetkov SN; Engelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str., 32, Moscow 119991, Russia., Balzarini J; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium., Daelemans D; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium., Pannecouque C; Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium., Seley-Radtke KL; Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA., Novikov MS; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 Mar 01; Vol. 23 (5), pp. 1069-81. Date of Electronic Publication: 2015 Jan 08.

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

Autor: Novikov MS; Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia., Valuev-Elliston VT, Babkov DA, Paramonova MP, Ivanov AV, Gavryushov SA, Khandazhinskaya AL, Kochetkov SN, Pannecouque C, Andrei G, Snoeck R, Balzarini J, Seley-Radtke KL

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2013 Mar 01; Vol. 21 (5), pp. 1150-8. Date of Electronic Publication: 2013 Jan 03.