Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Paramita M, Ghosh"'
Autor:
Sreyashi Bhattacharya, Hannah L. Harris, Ridwan Islam, Sanika Bodas, Navatha Polavaram, Juhi Mishra, Dipanwita Das, Parthasarathy Seshacharyulu, Achyuth Kalluchi, Anirban Pal, Manish Kohli, Subodh M. Lele, Michael Muders, Surinder K. Batra, Paramita M. Ghosh, Kaustubh Datta, M. Jordan Rowley, Samikshan Dutta
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-18 (2024)
Abstract Resistance to the current Androgen Receptor Signaling Inhibitor (ARSI) therapies has led to higher incidences of therapy-induced neuroendocrine-like prostate cancer (t-NEPC). This highly aggressive subtype with predominant small-cell-like ch
Externí odkaz:
https://doaj.org/article/2b98ea921a8d460aa22a9de1beae8f05
Autor:
Demitria M. Vasilatis, Neelu Batra, Christopher A. Lucchesi, Christine J. Abria, Eva-Maria Packeiser, Hugo Murua Escobar, Paramita M. Ghosh
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8628 (2024)
In prostate cancer (PCa), androgens upregulate tumorigenesis, whereas in benign tissue, the revival of androgen receptor (AR) signaling suppresses aggressive behaviors, suggesting therapeutic potential. Dogs, natural PCa models, often lack AR in PCa.
Externí odkaz:
https://doaj.org/article/bde6a8d319d04acf85cd99edff13dfbd
Autor:
Thomas M. Steele, Maria Malvina Tsamouri, Salma Siddiqui, Christopher A. Lucchesi, Demitria Vasilatis, Benjamin A. Mooso, Blythe P. Durbin-Johnson, Ai-Hong Ma, Nazila Hejazi, Mamta Parikh, Maria Mudryj, Chong-xian Pan, Paramita M. Ghosh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Cisplatin-based combination chemotherapy is the foundation for treatment of advanced bladder cancer (BlCa), but many patients develop chemoresistance mediated by increased Akt and ERK phosphorylation. However, the mechanism by which cisplati
Externí odkaz:
https://doaj.org/article/e7fd4fc41429405c9cbe1caf0f8d8467
Autor:
Kimberley D. Katleba, Maria-Malvina Tsamouri, Maitreyee Jathal, Han Bit Baek, Rebecca B. Armenta, Clifford G. Tepper, Gino Cortopassi, Paramita M. Ghosh, Maria Mudryj
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The observed sex disparity in bladder cancer (BlCa) argues that androgen receptor (AR) signaling has a role in these malignancies. BlCas express full-length AR (FL-AR), constitutively active AR splice variants, including AR-v19, or both, and
Externí odkaz:
https://doaj.org/article/808e9dbfa3f84e6190abe7c760f86466
Autor:
Shu Ning, Jinge Zhao, Alan P. Lombard, Leandro S. D’Abronzo, Amy R. Leslie, Masuda Sharifi, Wei Lou, Chengfei Liu, Joy C. Yang, Christopher P. Evans, Eva Corey, Hong-Wu Chen, Aiming Yu, Paramita M. Ghosh, Allen C. Gao
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-12 (2022)
Ning et al. report expression of a neural lineage gene signature in enzalutamide-resistant prostate cancer cells and datasets from patients with neuroendocrine prostate cancer. One of these genes, ARHGEF2, is associated with poor overall and disease-
Externí odkaz:
https://doaj.org/article/23a69cb8d6894a2792a756ea7fe5a961
Publikováno v:
Animals, Vol 14, Iss 4, p 588 (2024)
Clinicopathologic data in dogs with prostate cancer (PCa) may aid in the differentiation between tumor types and subsequent treatment decisions; however, these data are often unreported. Demographic, clinicopathologic, cytologic, histologic and survi
Externí odkaz:
https://doaj.org/article/eb23c0c0f3884653aaf6fb95498ce988
Autor:
Maria Mudryj, Paramita M. Ghosh
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/6881b847bc1d458687d999671dca8dd6
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2215 (2023)
Multiple studies have demonstrated the importance of androgen receptor (AR) splice variants (SVs) in the progression of prostate cancer to the castration-resistant phenotype and their utility as a diagnostic. However, studies on AR expression in non-
Externí odkaz:
https://doaj.org/article/c2ab9bea70ea4ba08174cddca8a6000c
Autor:
Christopher A. Lucchesi, Demitria M. Vasilatis, Saisamkalpa Mantrala, Thenappan Chandrasekar, Maria Mudryj, Paramita M. Ghosh
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11395 (2023)
Multiple risk factors have been associated with bladder cancer. This review focuses on pesticide exposure, as it is not currently known whether agricultural products have a direct or indirect effect on bladder cancer, despite recent reports demonstra
Externí odkaz:
https://doaj.org/article/2b6586a30b57449a9a096501cd5778a0
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1100 (2023)
Dogs are one of few species that naturally develop prostate cancer (PCa), which clinically resembles aggressive, advanced PCa in humans. Moreover, PCa-tumor samples from dogs are often androgen receptor (AR)-negative and may enrich our understanding
Externí odkaz:
https://doaj.org/article/8580e92809c440ffad0197c4a9c3a7fb