Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Parameswaran Ramakrishnan"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/f8fde46f69d54d43b3121cb5a58fa43d
Autor:
Parameswaran Ramakrishnan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/3cb03c3e775346cc9c85dda032ff4957
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAcute myeloid leukemia (AML) is the most common acute leukemia in adults with an overall poor prognosis and high relapse rate. Multiple factors including genetic abnormalities, differentiation defects and altered cellular metabolism contr
Externí odkaz:
https://doaj.org/article/fb5325fe89af4b1a9b46b685a4c97a0a
Autor:
Angela Rose Liu, Shrikanth C. Basavarajappa, Nandini Sarkar, Anna Bruchez, Parameswaran Ramakrishnan
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102127- (2023)
Summary: Here, we provide a protocol for the design, expression, purification, and functional studies of an engineered trimeric version of the receptor-binding domain (tRBD) of SARS-CoV-2 spike protein. We describe the use of tRBD to block SARS-CoV-2
Externí odkaz:
https://doaj.org/article/24c51f8fdbce454491a878a87683f4fe
Autor:
Shrikanth C. Basavarajappa, Angela Rose Liu, Anna Bruchez, Zhenlu Li, Vinicius G. Suzart, Zhonghua Liu, Yinghua Chen, Tsan Sam Xiao, Matthias Buck, Parameswaran Ramakrishnan
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104716- (2022)
Summary: The COVID-19 pandemic has caused over four million deaths and effective methods to control CoV-2 infection, in addition to vaccines, are needed. The CoV-2 binds to the ACE2 on human cells through the receptor-binding domain (RBD) of the trim
Externí odkaz:
https://doaj.org/article/508bab6f07544024beeba26ed518f0ae
Autor:
Daniel Feinberg, Parameswaran Ramakrishnan, Derek P. Wong, Abhishek Asthana, Reshmi Parameswaran
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cells mediate killing of malignant and virus-infected cells, a property that is explored as a cell therapy approach in the clinic. Various cell intrinsic and extrinsic factors affect NK cell cytotoxic function, and an improved und
Externí odkaz:
https://doaj.org/article/875da34f28f14209a91c0aba8e44c4aa
Autor:
Liqun Zhang, Santosh K. Ghosh, Shrikanth C. Basavarajappa, Yinghua Chen, Pravesh Shrestha, Jackson Penfield, Ann Brewer, Parameswaran Ramakrishnan, Matthias Buck, Aaron Weinberg
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103856- (2022)
Summary: New approaches to complement vaccination are needed to combat the spread of SARS-CoV-2 and stop COVID-19-related deaths and medical complications. Human beta defensin 2 (hBD-2) is a naturally occurring epithelial cell-derived host defense pe
Externí odkaz:
https://doaj.org/article/47bee7f4563c41228415095c02165af0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Nuclear factor-kappaB (NF-κB) is a pleiotropic, evolutionarily conserved transcription factor family that plays a central role in regulating immune responses, inflammation, cell survival, and apoptosis. Great strides have been made in the past three
Externí odkaz:
https://doaj.org/article/53bb470914ed4ab6bc89a13c12f20df1
Autor:
Yorleny Vicioso, Derek P. Wong, Nand K. Roy, Nayanika Das, Keman Zhang, Parameswaran Ramakrishnan, Reshmi Parameswaran
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant
Externí odkaz:
https://doaj.org/article/1e2ba25e6eb847bc9762c718e8b8923e
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: NF-κB/Rel family of transcription factors plays a central role in initiation and resolution of inflammatory responses. Here, we identified a function of the NF-κB subunit c-Rel as a transcriptional repressor of inflammatory genes. Genetic
Externí odkaz:
https://doaj.org/article/21046350045c46c8a8bd34fe3eb5b716