Zobrazeno 1 - 10
of 398
pro vyhledávání: '"Parameswaran G"'
Autor:
Thomas E. Bartlett, Iona Evans, Allison Jones, James E. Barrett, Shaun Haran, Daniel Reisel, Kiriaki Papaikonomou, Louise Jones, Chiara Herzog, Nora Pashayan, Bruno M. Simões, Robert B. Clarke, D. Gareth Evans, Talayeh S. Ghezelayagh, Sakthivignesh Ponandai-Srinivasan, Nageswara R. Boggavarapu, Parameswaran G. Lalitkumar, Sacha J. Howell, Rosa Ana Risques, Angelique Flöter Rådestad, Louis Dubeau, Kristina Gemzell-Danielsson, Martin Widschwendter
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Background Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising pr
Externí odkaz:
https://doaj.org/article/3c4f667ea36343489d62c2a38deb1ee7
Autor:
Sara Aly Attia, Anh Tan Truong, Alvin Phan, Shin-Jae Lee, Manal Abanmai, Marinella Markanovic, Hugo Avila, Haozhong Luo, Atham Ali, Parameswaran G. Sreekumar, Ram Kannan, J. Andrew MacKay
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1817 (2023)
Background: Oxidative stress-induced retinal degeneration is among the main contributing factors of serious ocular pathologies that can lead to irreversible blindness. αB-crystallin (cry) is an abundant component of the visual pathway in the vitreou
Externí odkaz:
https://doaj.org/article/5deb9dd39dfd4dd2a098780ba9fea69d
Autor:
Thomas E. Bartlett, Iona Evans, Allison Jones, James E. Barrett, Shaun Haran, Daniel Reisel, Kiriaki Papaikonomou, Louise Jones, Chiara Herzog, Nora Pashayan, Bruno M. Simões, Robert B. Clarke, D. Gareth Evans, Talayeh S. Ghezelayagh, Sakthivignesh Ponandai-Srinivasan, Nageswara R. Boggavarapu, Parameswaran G. Lalitkumar, Sacha J. Howell, Rosa Ana Risques, Angelique Flöter Rådestad, Louis Dubeau, Kristina Gemzell-Danielsson, Martin Widschwendter
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/e33dc40c9a65449694cb3d0e780845d4
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 2080 (2022)
Proliferative Vitreoretinopathy (PVR) is a refractory retinal disease whose primary pathogenesis involves the epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells. At present, there is no effective treatment other than su
Externí odkaz:
https://doaj.org/article/27098dc2ac4a4c2eb84e41720ccd89fd
Autor:
Parameswaran G. Sreekumar, Ram Kannan
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101663- (2020)
The mitochondrial-derived peptides (MDPs) are a new class of small open reading frame encoded polypeptides with pleiotropic properties. The prominent members are Humanin (HN) and small HN-like peptide (SHLP) 2, which encode 16S rRNA, while mitochondr
Externí odkaz:
https://doaj.org/article/3e0619dd261f4c41889c69e2eecb9de6
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 1, Pp 35-38 (2017)
In this review, the interactive mechanisms of mitochondria with the endoplasmic reticulum (ER) are discussed with emphasis on the potential protective role of the mitochondria derived peptide humanin (HN) in ER stress. The ER and mitochondria are dyn
Externí odkaz:
https://doaj.org/article/0606b14f22904965a968f378d9d9adf7
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 661 (2021)
Glutathione (GSH) is present ubiquitously, and its role as a crucial cellular antioxidant in tissues, including the retina, is well established. GSH’s antioxidant function arises from its ability to scavenge reactive oxygen species or to serve as a
Externí odkaz:
https://doaj.org/article/558ac6d26c88444c986d37de264d9c61
Publikováno v:
Antioxidants, Vol 9, Iss 5, p 411 (2020)
Mitochondrial glutathione (mGSH) is critical for cell survival. We recently reported the localization of OGC (SLC25A11) and DIC (SLC25A10) in hRPE. Herein, we investigated the suppression of OGC and DIC and the effect of αB crystallin chaperone pept
Externí odkaz:
https://doaj.org/article/35d1c5b78c7c4f6a9f8712e3a6ca76c9
Autor:
Douglas Matsunaga, Parameswaran G Sreekumar, Keijiro Ishikawa, Hiroto Terasaki, Ernesto Barron, Pinchas Cohen, Ram Kannan, David R Hinton
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165150 (2016)
Humanin (HN) is a small mitochondrial-encoded peptide with neuroprotective properties. We have recently shown protection of retinal pigmented epithelium (RPE) cells by HN in oxidative stress; however, the effect of HN on endoplasmic reticulum (ER) st
Externí odkaz:
https://doaj.org/article/8d1f6bb2bf164a69a289aaeca1521478
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98275 (2014)
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD and αB crystallin expression is increased in RPE and associated drusen in AMD.
Externí odkaz:
https://doaj.org/article/62f3fe593fbc47c9ab034115b3320fb7