PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.

Autor: Duchatel RJ; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Paediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, New South Wales, Australia., Jackson ER; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Paediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, New South Wales, Australia., Parackal SG; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia., Kiltschewskij D; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., Findlay IJ; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Paediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, New South Wales, Australia., Mannan A; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., Staudt DE; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Paediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, New South Wales, Australia., Thomas BC; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Paediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, New South Wales, Australia., Germon ZP; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., Laternser S; DIPG/DMG Research Center Zurich, Children's Research Center, Department of Pediatrics, University Children's Hospital Zürich, Zurich, Switzerland., Kearney PS; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., Jamaluddin MFB; School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., Douglas AM; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., Beitaki T; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., McEwen HP; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., Persson ML; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Paediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, New South Wales, Australia., Hocke EA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Jain V; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Aksu M; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Manning EE; School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., Murray HC; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., Verrills NM; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., Sun CX; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia., Daniel P; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia., Vilain RE; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., Skerrett-Byrne DA; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., Nixon B; Infertility and Reproduction Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia., Hua S; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., de Bock CE; Children's Cancer Institute, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Kensington, New South Wales, Australia., Colino-Sanguino Y; Children's Cancer Institute, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Kensington, New South Wales, Australia., Valdes-Mora F; Children's Cancer Institute, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Kensington, New South Wales, Australia., Tsoli M; Children's Cancer Institute, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Kensington, New South Wales, Australia., Ziegler DS; Children's Cancer Institute, University of New South Wales (UNSW) Sydney, Kensington, New South Wales, Australia.; School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Kensington, New South Wales, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia., Cairns MJ; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., Raabe EH; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vitanza NA; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA., Hulleman E; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Phoenix TN; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA., Koschmann C; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA., Alvaro F; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; John Hunter Children's Hospital, New Lambton Heights, New South Wales, Australia., Dayas CV; School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia., Tinkle CL; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Wheeler H; Department of Radiation Oncology Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, New South Wales, Australia.; The Brain Cancer group, St Leonards, New South Wales, Australia.; Sydney Medical School, University of Sydney, Sydney, Australia., Whittle JR; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Eisenstat DD; Children's Cancer Centre, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.; Neuro-Oncology Laboratory, Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia., Firestein R; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia., Mueller S; DIPG/DMG Research Center Zurich, Children's Research Center, Department of Pediatrics, University Children's Hospital Zürich, Zurich, Switzerland.; Department of Neurology, Neurosurgery, and Pediatrics, University of California, San Francisco, California, USA., Valvi S; Department of Paediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, Washington, Australia.; Brain Tumour Research Laboratory, Telethon Kids Institute, Nedlands, Washington, Australia.; Division of Paediatrics, University of Western Australia Medical School, Nedlands, Western Australia, Australia., Hansford JR; Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.; South Australia Health and Medical Research Institute, Adelaide, South Australia, Australia.; South Australian Immunogenomics Cancer Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia., Ashley DM; The Preston Robert Tisch Brain Tumor Center at Duke, Department of Neurosurgery, Duke University, Durham, North Carolina, USA., Gregory SG; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.; The Preston Robert Tisch Brain Tumor Center at Duke, Department of Neurosurgery, Duke University, Durham, North Carolina, USA., Kilburn LB; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA.; The George Washington University, School of Medicine and Health Sciences, Washington, DC, USA., Nazarian J; DIPG/DMG Research Center Zurich, Children's Research Center, Department of Pediatrics, University Children's Hospital Zürich, Zurich, Switzerland.; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA.; The George Washington University, School of Medicine and Health Sciences, Washington, DC, USA., Cain JE; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia., Dun MD; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; Paediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine, and Wellbeing, Callaghan, New South Wales, Australia.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Feb 06; Vol. 134 (6). Date of Electronic Publication: 2024 Feb 06.