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Autor:
Ge AY; School of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Arab A; Arc Institute, Palo Alto, CA, 94304, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Dai R; Arc Institute, Palo Alto, CA, 94304, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Navickas A; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94158, USA., Fish L; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94158, USA., Garcia K; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94158, USA., Asgharian H; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94158, USA., Goudreau J; Arc Institute, Palo Alto, CA, 94304, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94158, USA., Lee S; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94158, USA., Keenan K; Tumor Cell Targeting Research Unit, Research, GSK, Collegeville, PA, 19426, USA., Pappalardi MB; Tumor Cell Targeting Research Unit, Research, GSK, Collegeville, PA, 19426, USA., McCabe MT; Tumor Cell Targeting Research Unit, Research, GSK, Collegeville, PA, 19426, USA., Przybyla L; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA.; Laboratory for Genomics Research, San Francisco, CA, 94158, USA., Goodarzi H; Arc Institute, Palo Alto, CA, 94304, USA. Hani@arcinstitute.org.; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA. Hani@arcinstitute.org.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA. Hani@arcinstitute.org.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94158, USA. Hani@arcinstitute.org.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94158, USA. Hani@arcinstitute.org., Gilbert LA; Arc Institute, Palo Alto, CA, 94304, USA. Luke@arcinstitute.org.; Department of Urology, University of California, San Francisco, San Francisco, CA, 94158, USA. Luke@arcinstitute.org.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA. Luke@arcinstitute.org.
Publikováno v:
Scientific reports [Sci Rep] 2024 Oct 29; Vol. 14 (1), pp. 25940. Date of Electronic Publication: 2024 Oct 29.
Autor:
Patel AJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Warda S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Maag JLV; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York., Misra R; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York., Miranda-Román MA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York., Pachai MR; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Lee CJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Li D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Wang N; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Bayshtok G; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Fishinevich E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Meng Y; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York., Wong EWP; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Yan J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Giff E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Pappalardi MB; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, Pennsylvania., McCabe MT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, Pennsylvania., Fletcher JA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Rudin CM; Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York.; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York., Chandarlapaty S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Medical College, New York, New York., Scandura JM; Laboratory of Molecular Hematopoiesis, Hematology and Oncology, Weill Cornell Medicine, New York, New York.; Richard T. Silver MD Myeloproliferative Neoplasm Center, Weill Cornell Medicine, New York, New York.; Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York., Koche RP; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York., Glass JL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York.; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York., Antonescu CR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Zheng D; The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York., Chen Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Weill Cornell Medical College, New York, New York., Chi P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Weill Cornell Medical College, New York, New York.
Publikováno v:
Cancer discovery [Cancer Discov] 2022 Sep 02; Vol. 12 (9), pp. 2120-2139.
Autor:
Wiseman AK; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA., Tiedemann RL; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA., Fan H; Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Shen H; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA., Madaj Z; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA., McCabe MT; Cancer Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Pappalardi MB; Cancer Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Jones PA; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA. Peter.Jones@vai.org.
Publikováno v:
Communications biology [Commun Biol] 2022 Jun 02; Vol. 5 (1), pp. 528. Date of Electronic Publication: 2022 Jun 02.
Autor:
Horton JR; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Pathuri S; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wong K; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA 19426, USA., Ren R; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Rueda L; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA 19426, USA., Fosbenner DT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA 19426, USA., Heerding DA; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA 19426, USA., McCabe MT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA 19426, USA., Pappalardi MB; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA 19426, USA., Zhang X; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., King BW; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address: bryan.w.king@gsk.com., Cheng X; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: xcheng5@mdanderson.org.
Publikováno v:
Structure (London, England : 1993) [Structure] 2022 Jun 02; Vol. 30 (6), pp. 793-802.e5. Date of Electronic Publication: 2022 Apr 07.
Autor:
Pappalardi MB; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Keenan K; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Cockerill M; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK.; These authors contributed equally: Mark Cockerill, Wendy A. Kellner., Kellner WA; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA.; These authors contributed equally: Mark Cockerill, Wendy A. Kellner., Stowell A; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Sherk C; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Wong K; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Pathuri S; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Briand J; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Steidel M; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Chapman P; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Groy A; Future Pipeline Discovery, GlaxoSmithKline, Collegeville, PA, USA., Wiseman AK; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA., McHugh CF; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Campobasso N; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Graves AP; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Fairweather E; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Werner T; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Raoof A; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Butlin RJ; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Rueda L; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Horton JR; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fosbenner DT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Zhang C; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Handler JL; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Muliaditan M; Drug Metabolism and Pharmacokinetics Modelling, GlaxoSmithKline, Stevenage, UK., Mebrahtu M; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Jaworski JP; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., McNulty DE; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Burt C; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Eberl HC; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Taylor AN; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Ho T; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Merrihew S; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Foley SW; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Rutkowska A; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Li M; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Romeril SP; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Goldberg K; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Zhang X; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kershaw CS; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Bantscheff M; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Jurewicz AJ; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Minthorn E; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Grandi P; Cellzome GmbH, Functional Genomics, GlaxoSmithKline, Heidelberg, Germany., Patel M; Medicinal Science & Technology, GlaxoSmithKline, Collegeville, PA, USA., Benowitz AB; Future Pipeline Discovery, GlaxoSmithKline, Collegeville, PA, USA., Mohammad HP; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Gilmartin AG; Future Pipeline Discovery, GlaxoSmithKline, Collegeville, PA, USA., Prinjha RK; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Ogilvie D; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Carpenter C; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Heerding D; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Baylin SB; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA., Jones PA; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA., Cheng X; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, USA., King BW; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Luengo JI; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Jordan AM; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Waddell I; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield, UK., Kruger RG; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA.
Publikováno v:
Nature cancer [Nat Cancer] 2021 Oct; Vol. 2 (10), pp. 1002-1017. Date of Electronic Publication: 2021 Sep 27.
Autor:
Haggerty C; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany., Kretzmer H; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany., Riemenschneider C; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany., Kumar AS; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany., Mattei AL; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Bailly N; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany., Gottfreund J; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany., Giesselmann P; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany., Weigert R; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany., Brändl B; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Christian-Albrechts-Universität zu Kiel, Department of Psychiatry and Psychotherapy, Kiel, Germany., Giehr P; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland., Buschow R; Microscopy and Cryo-electron Microscopy Service Group, Max Planck Institute for Molecular Genetics, Berlin, Germany., Galonska C; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Spatial Transcriptomics, Part of 10x Genomics Inc, Stockholm, Sweden., von Meyenn F; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland., Pappalardi MB; Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Epigenetics Research Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Wittler L; Department of Developmental Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany., Giesecke-Thiel C; Flow Cytometry Joint Facilities Scientific Service, Max Planck Institute for Molecular Genetics, Berlin, Germany., Mielke T; Microscopy and Cryo-electron Microscopy Service Group, Max Planck Institute for Molecular Genetics, Berlin, Germany., Meierhofer D; Mass Spectrometry Joint Facilities Scientific Service, Max Planck Institute for Molecular Genetics, Berlin, Germany., Timmermann B; Sequencing Core Facility, Max Planck Institute for Molecular Genetics, Berlin, Germany., Müller FJ; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Christian-Albrechts-Universität zu Kiel, Department of Psychiatry and Psychotherapy, Kiel, Germany., Walter J; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany., Meissner A; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany. meissner@molgen.mpg.de.; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. meissner@molgen.mpg.de.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. meissner@molgen.mpg.de.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. meissner@molgen.mpg.de.
Publikováno v:
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Jul; Vol. 28 (7), pp. 594-603. Date of Electronic Publication: 2021 Jun 17.
Autor:
Su DS; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Qu J; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Schulz M; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Blackledge CW; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Yu H; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Zeng J; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Burgess J; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Reif A; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Stern M; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Nagarajan R; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Pappalardi MB; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Wong K; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Graves AP; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Bonnette W; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Wang L; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Elkins P; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Knapp-Reed B; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Carson JD; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., McHugh C; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Mohammad H; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Kruger R; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Luengo J; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Heerding DA; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Creasy CL; Medicinal Chemistry, Medicine Design, Oncology R&D, Data and Computational Sciences, and Protein Cellular and Structural Sciences, Medicine Design, Medicinal Science and Technology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Dec 27; Vol. 11 (2), pp. 133-140. Date of Electronic Publication: 2019 Dec 27 (Print Publication: 2020).
Autor:
Fedoriw A; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Rajapurkar SR; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., O'Brien S; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Gerhart SV; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Mitchell LH; Epizyme, Inc, Cambridge, MA 02139, USA., Adams ND; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Rioux N; Epizyme, Inc, Cambridge, MA 02139, USA., Lingaraj T; Epizyme, Inc, Cambridge, MA 02139, USA., Ribich SA; Epizyme, Inc, Cambridge, MA 02139, USA., Pappalardi MB; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Shah N; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Laraio J; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Liu Y; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Butticello M; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Carpenter CL; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Creasy C; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Korenchuk S; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., McCabe MT; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., McHugh CF; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Nagarajan R; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Wagner C; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Zappacosta F; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Annan R; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Concha NO; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA 19426, USA., Thomas RA; Nonclinical Safety Assessment, GlaxoSmithKline, Collegeville, PA 19426, USA., Hart TK; Nonclinical Safety Assessment, GlaxoSmithKline, Collegeville, PA 19426, USA., Smith JJ; Epizyme, Inc, Cambridge, MA 02139, USA., Copeland RA; Epizyme, Inc, Cambridge, MA 02139, USA., Moyer MP; Epizyme, Inc, Cambridge, MA 02139, USA., Campbell J; Epizyme, Inc, Cambridge, MA 02139, USA., Stickland K; Epizyme, Inc, Cambridge, MA 02139, USA., Mills J; Epizyme, Inc, Cambridge, MA 02139, USA., Jacques-O'Hagan S; Epizyme, Inc, Cambridge, MA 02139, USA., Allain C; Epizyme, Inc, Cambridge, MA 02139, USA., Johnston D; Epizyme, Inc, Cambridge, MA 02139, USA., Raimondi A; Epizyme, Inc, Cambridge, MA 02139, USA., Porter Scott M; Epizyme, Inc, Cambridge, MA 02139, USA., Waters N; Epizyme, Inc, Cambridge, MA 02139, USA., Swinger K; Epizyme, Inc, Cambridge, MA 02139, USA., Boriack-Sjodin A; Epizyme, Inc, Cambridge, MA 02139, USA., Riera T; Epizyme, Inc, Cambridge, MA 02139, USA., Shapiro G; Epizyme, Inc, Cambridge, MA 02139, USA., Chesworth R; Epizyme, Inc, Cambridge, MA 02139, USA., Prinjha RK; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Kruger RG; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Barbash O; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA., Mohammad HP; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address: helai.x.mohammad@gsk.com.
Publikováno v:
Cancer cell [Cancer Cell] 2019 Jul 08; Vol. 36 (1), pp. 100-114.e25. Date of Electronic Publication: 2019 Jun 27.
Autor:
Smitheman KN; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Severson TM; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands., Rajapurkar SR; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Karpinich N; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Foley J; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Pappalardi MB; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Hughes A; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA., Halsey W; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA., Thomas E; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA., Traini C; Target Sciences, GlaxoSmithKline, Collegeville, PA, USA., Federowicz KE; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Laraio J; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Mobegi F; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands., Ferron-Brady G; Clinical Pharmacology and Modeling Sciences, GlaxoSmithKline, Collegeville, PA, USA., Prinjha RK; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Carpenter CL; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Kruger RG; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Wessels L; Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Faculty of EEMCS, Delft University of Technology, the Netherlands., Mohammad HP; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA helai.x.mohammad@gsk.com.
Publikováno v:
Haematologica [Haematologica] 2019 Jun; Vol. 104 (6), pp. 1156-1167. Date of Electronic Publication: 2018 Dec 04.