Frameshift Mutations in Genes Encoding PBP3 and PBP4 Trigger an Unusual, Extreme β-Lactam Resistance Phenotype in Burkholderia multivorans .

Autor: Mojica MF; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.; Research Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio 44106, United States.; CASE-VA Center for Antimicrobial Resistance and Epidemiology, Cleveland, Ohio 44106, United States., Nukaga M; Pharmaceutical Sciences, Josai International University, Togane City, Chiba 283-8555, Japan., Becka SA; Research Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio 44106, United States., Zeiser ET; Research Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio 44106, United States., Hoshino T; Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 263-8522, Japan., LiPuma JJ; Department of Pediatrics and Communicable Disease, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States., Papp-Wallace KM; Research Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio 44106, United States.; CASE-VA Center for Antimicrobial Resistance and Epidemiology, Cleveland, Ohio 44106, United States.; Departments of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.; Departments of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Nov 08; Vol. 10 (11), pp. 3810-3820. Date of Electronic Publication: 2024 Oct 23.

ARGONAUT-IV: susceptibility of carbapenemase-producing Klebsiella pneumoniae to the oral bicyclic boronate β-lactamase inhibitor ledaborbactam combined with ceftibuten.

Autor: Jacobs MR; Case Western Reserve University, Cleveland, Ohio, USA.; University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Good CE; University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Abdelhamed AM; University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Mack AR; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA., Bethel CR; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA., Marshall SH; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA., Hujer AM; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Hujer KM; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Patel R; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., van Duin D; Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA., Fowler VG; Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA., Rhoads DD; Case Western Reserve University, Cleveland, Ohio, USA.; Department of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA., Six DA; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Moeck G; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Uehara T; Venatorx Pharmaceuticals, Inc., Malvern, Pennsylvania, USA., Papp-Wallace KM; Case Western Reserve University, Cleveland, Ohio, USA.; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA., Bonomo RA; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Departments of Biochemistry, Pharmacology, Proteomics and Bioinformatics Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Oct 30, pp. e0112724. Date of Electronic Publication: 2024 Oct 30.

Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase.

Autor: Mack AR; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Research Service, VA Northeast Ohio Healthcare System , Cleveland, Ohio, USA., Kumar V; Department of Biochemistry, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA., Taracila MA; Research Service, VA Northeast Ohio Healthcare System , Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA., Mojica MF; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Research Service, VA Northeast Ohio Healthcare System , Cleveland, Ohio, USA.; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) , Cleveland, Ohio, USA., O'Shea M; Research Service, VA Northeast Ohio Healthcare System , Cleveland, Ohio, USA., Schinabeck W; Research Service, VA Northeast Ohio Healthcare System , Cleveland, Ohio, USA., Silver G; Research Service, VA Northeast Ohio Healthcare System , Cleveland, Ohio, USA., Hujer AM; Research Service, VA Northeast Ohio Healthcare System , Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA., Papp-Wallace KM; Research Service, VA Northeast Ohio Healthcare System , Cleveland, Ohio, USA.; Department of Biochemistry, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA., Chen S; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London , London, England, United Kingdom., Haider S; Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London , London, England, United Kingdom.; UCL Centre for Advanced Research Computing, University College London , London, England, United Kingdom., Caselli E; Department of Life Sciences, University of Modena and Reggio Emilia , Modena, Italy., Prati F; Department of Life Sciences, University of Modena and Reggio Emilia , Modena, Italy., van den Akker F; Department of Biochemistry, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA., Bonomo RA; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Department of Biochemistry, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) , Cleveland, Ohio, USA.; Department of Pharmacology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Clinician Scientist Investigator, Louis Stokes Cleveland Department of Veterans Affairs Medical Center , Cleveland, Ohio, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Nov 15; Vol. 67 (11), pp. e0079123. Date of Electronic Publication: 2023 Oct 18.

Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water.

Autor: Alsenani TA; Department of Biochemistry, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA., Viviani SL; Department of Biochemistry, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA., Papp-Wallace KM; Clinical Scientist Investigator, Louis Stokes Cleveland Department of Veterans Affairs Medical Center , North liberty, Iowa, USA., Bonomo RA; Department of Biochemistry, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Clinical Scientist Investigator, Louis Stokes Cleveland Department of Veterans Affairs Medical Center , North liberty, Iowa, USA.; Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Department of Pharmacology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) , Cleveland, Ohio, USA., van den Akker F; Department of Biochemistry, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Oct 18; Vol. 67 (10), pp. e0035023. Date of Electronic Publication: 2023 Sep 26.

Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species.

Autor: Papp-Wallace KM; Research Service, Veterans Affairs Northeast Ohio Healthcare System, USA.; Departments of Biochemistry and Medicine, Case Western Reserve University, Cleveland, OH, USA., McLeod SM; Entasis Therapeutics, Waltham, MA, USA., Miller AA; Entasis Therapeutics, Waltham, MA, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 May 01; Vol. 76 (Suppl 2), pp. S194-S201.