Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Papireddy, Kancharla"'
Autor:
Monish Yeluguri, Jane Xu Kelly, Rozalia A. Dodean, Kevin A. Reynolds, Papireddy Kancharla, Yuexin Li
Publikováno v:
Journal of Medicinal Chemistry. 64:8739-8754
Highly efficient and straightforward synthetic routes toward the first total synthesis of 2-(p-hydroxybenzyl)-prodigiosins (2-5), isoheptylprodigiosin (6), and geometric isomers of tambjamine MYP1 ((E/Z)-7) have been developed. The crucial steps invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42c1363e844377f75f67fd1700a884ce
https://doi.org/10.1021/acs.jmedchem.1c00748
https://doi.org/10.1021/acs.jmedchem.1c00748
Autor:
Jane Xu Kelly, Rozalia A. Dodean, Papireddy Kancharla, Erin V. McConnell, Jan M. Boitz Zarella, J. Stone Doggett, P. Holland Alday
Publikováno v:
ACS Infectious Diseases. 7:1877-1884
Acridone derivatives, which have been shown to have in vitro and in vivo activity against Plasmodium spp, inhibit Toxoplasma gondii proliferation at picomolar concentrations. Using enzymatic assays, we show that acridones inhibit both T. gondii cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc7aa68b816b960c6000495d3958c3e
https://doi.org/10.1021/acsinfecdis.1c00016
https://doi.org/10.1021/acsinfecdis.1c00016
Autor:
Bonnett, Shilah A., Whicher, Jonathan R., Papireddy, Kancharla, Florova, Galina, Smith, Janet L., Reynolds, Kevin A.
Publikováno v:
In Chemistry & Biology 20 June 2013 20(6):772-783
Autor:
Roland A. Cooper, Susan E. Leed, Qiang Zeng, Kevin A. Reynolds, Lacy Gaynor-Ohnstad, Lisa Xie, Hsiuling Lin, Jason C. Sousa, Jianbing Mu, Heather Gaona, Raul Olmeda, Martin J. Smilkstein, Brett R. Bayles, Brittney Potter, Michael K. Riscoe, Richard J. Sciotti, Papireddy Kancharla, Yuexin Li, Brian Vesely, Sovitj Pou, Sean R. Marcsisin, Chau Vuong, Qigui Li, Brandon S. Pybus, Lisa Read, Victor Melendez, Norma Roncal, Thu Lan Luong, Diana Caridha, Chad C. Black, Rozalia A. Dodean, Jing Zhang, Kirk Butler, Patrick K Tumwebaze, Charles E. Bane, Philip J. Rosenthal, Stephanie A Rasmussen, Mara Kreishman-Deitrick, Jane Xu Kelly, Frida G. Ceja, Ping Zhang, Christina K. Nolan
Publikováno v:
J Med Chem
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8e0165bf6ef34369b69238cb312a6
https://doi.org/10.1021/acs.jmedchem.0c00539
https://doi.org/10.1021/acs.jmedchem.0c00539
Publikováno v:
RSC Adv
A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF(3).Et(2)O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed. The reaction proceeds under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1820933c5860add1e9fefecd69fe7346
https://doi.org/10.1039/c9ra09478d
https://doi.org/10.1039/c9ra09478d
Autor:
P Holland, Alday, Erin V, McConnell, Jan M, Boitz Zarella, Rozalia A, Dodean, Papireddy, Kancharla, Jane X, Kelly, J Stone, Doggett
Publikováno v:
ACS Infect Dis
Acridone derivatives, which have been shown to have in vitro and in vivo activity against Plasmodium spp, inhibit Toxoplasma gondii proliferation at picomolar concentrations. Using enzymatic assays, we show that acridones inhibit both T. gondii cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::965472a1a703b6539d887f1203a53ac3
https://pubmed.ncbi.nlm.nih.gov/33723998
https://pubmed.ncbi.nlm.nih.gov/33723998
Publikováno v:
Org Lett
A novel bifunctional enzyme, MarH, has been identified, and its key functional role in the marineosin biosynthesis successfully probed. MarH catalyzes (1) a condensation step between 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC) and 2-undecylpyrrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de75f3c605bc7765e1fd7a7dc00b6cf
https://doi.org/10.1021/acs.orglett.7b00093
https://doi.org/10.1021/acs.orglett.7b00093
Autor:
Yuexin Li, Kirk Butler, Brittney Potter, Qigui Li, Papireddy Kancharla, Roland A. Cooper, Thu Lan Luong, Heather Gaona, Jing Zhang, Richard J. Sciotti, Brian Vesely, Chau Vuong, Qiang Zeng, Sean R. Marcsisin, Michael K. Riscoe, Diana Caridha, Jason C. Sousa, Rolf W. Winter, Norma Roncal, Christina K. Nolan, Lisa Read, Rozalia A. Dodean, Lisa Xie, Lacy Gaynor-Ohnstad, Stephanie J. Huezo, Susan E. Leed, Hsiuling Lin, John C. Tan, Martin J. Smilkstein, Stephanie A Rasmussen, Jane Xu Kelly, Ping Zhang, Chad C. Black, Melissa T. Stephens, Mara Kreishman-Deitrick, Raul Olmeda, Victor Melendez, Sovitj Pou, Charles E. Bane
Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351c0f6f16032d54883ac7a5e8be555b
https://europepmc.org/articles/PMC6822569/
https://europepmc.org/articles/PMC6822569/
Publikováno v:
The Journal of Organic Chemistry
Facile and highly efficient synthetic routes for the synthesis of (S)- and (R)-23-hydroxyundecylprodiginines ((23S)-2, and (23R)-2), 23-ketoundecylprodiginine (3), and deuterium-labeled 23-hydroxyundecylprodiginine ([23-d]-2) have been developed. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eb0733349eb9044c7c9c2b050e51e7
https://doi.org/10.1021/jo5023553
https://doi.org/10.1021/jo5023553
Autor:
Galina Florova, Kevin A. Reynolds, Papireddy Kancharla, Shweta Gupta, Wanli Lu, Shaimaa M. Salem
Publikováno v:
Journal of the American Chemical Society
The marine Streptomyces sp. CNQ-617 produces two diastereomers, marineosins A and B. These are structurally related to alkyl prodiginines, but with a more complex cyclization and an unusual spiroaminal skeleton. We report the identification of the ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32463c7696ea4eacaca124763674a5e5
https://doi.org/10.1021/ja411544w
https://doi.org/10.1021/ja411544w