Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Papers of the Week"'
Autor:
Xiangyu Cai, Ping Xin, Yandong Zhou, Donald L. Gill, Mohamed Trebak, Natalia A. Loktionova, Youjun Wang, Robert M. Nwokonko, Xianming Wang
Publikováno v:
Journal of Biological Chemistry. 291:25764-25775
Orai channels mediate store-operated Ca2+ signals crucial in regulating transcription in many cell types, and implicated in numerous immunological and inflammatory disorders. Despite their central importance, controversy surrounds the basic subunit s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ecae490103bc980f6f4362832e7dbc6
https://doi.org/10.1074/jbc.m116.758813
https://doi.org/10.1074/jbc.m116.758813
Publikováno v:
Journal of Biological Chemistry. 291:26950-26957
Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells. The islet-specific zinc transporter ZnT8 mediates granular sequestration of zinc ions. A genetic variant of human ZnT8 arising from a single nonsynonym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976976a6c18d90328c223c4655ad4f3f
https://doi.org/10.1074/jbc.m116.764605
https://doi.org/10.1074/jbc.m116.764605
Autor:
Nathan T. Jui, Jozef Stec, Autumn R. Flynn, Devrishi Goswami, Patrick R. Griffin, C. Denise Okafor, Michael C. Dugan, Richard J. Whitby, Suzanne G. Mays, Eric A. Ortlund
Publikováno v:
Journal of Biological Chemistry. 291:25281-25291
Liver receptor homolog 1 (NR5A2, LRH-1) is an orphan nuclear hormone receptor that regulates diverse biological processes, including metabolism, proliferation, and the resolution of endoplasmic reticulum stress. Although preclinical and cellular stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2126458f02beb5390b195ebfe57efec6
https://doi.org/10.1074/jbc.m116.753541
https://doi.org/10.1074/jbc.m116.753541
Publikováno v:
Journal of Biological Chemistry. 291:26252-26261
Aldehyde dehydrogenase typically performs oxidation of aldehydes to their corresponding carboxylic acid while reducing NAD(P)+ to NAD(P)H via covalent catalysis mediated by an active-site cysteine residue. One member of this superfamily, the enzyme 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfdca23187c267c46b207d846ff5d6a
https://doi.org/10.1074/jbc.m116.759712
https://doi.org/10.1074/jbc.m116.759712
Autor:
Sam F. Rowe, Julia M. Kurth, Kevin Denkmann, Margarida Archer, Inês A. C. Pereira, José A. Brito, Thomas Franke, Jula Reuter, Christiane Dahl, Alexander Flegler, Eva-Maria Klein, Tobias Koch, Julea N. Butt
Publikováno v:
Journal of Biological Chemistry
The enzymes of the thiosulfate dehydrogenase (TsdA) family are wide-spread diheme c-type cytochromes. Here, redox carriers were studied mediating the flow of electrons arising from thiosulfate oxidation into respiratory or photosynthetic electron cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf22fa149a057cbc87ef0156519bae2
https://doi.org/10.1074/jbc.m116.753863
https://doi.org/10.1074/jbc.m116.753863
Autor:
Robert J. Maier, Stéphane L. Benoit
Publikováno v:
Journal of Biological Chemistry. 291:23366-23373
Catalase, a conserved and abundant enzyme found in all domains of life, dissipates the oxidant hydrogen peroxide (H2O2). The gastric pathogen Helicobacter pylori undergoes host-mediated oxidant stress exposure, and its catalase contains oxidizable me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585f983e89c97e46886b5916d22ceec5
https://doi.org/10.1074/jbc.m116.747881
https://doi.org/10.1074/jbc.m116.747881
Autor:
Felix Schuebel, Julia Schessner, Clara Brieke, Andrea Rocker, Anton Meinhart, Daniel Edelmann
Publikováno v:
The Journal of Biological Chemistry
An arsenal of effector proteins is injected by bacterial pathogens into the host cell or its vicinity to increase virulence. The commonly used top-down approaches inferring the toxic mechanism of individual effector proteins from the host's phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d7a597c736bb3841af9ebdeb431c53
https://doi.org/10.1074/jbc.m116.751297
https://doi.org/10.1074/jbc.m116.751297
Autor:
Venkateswara Rao Amara, Ekta Sharma, Himani Pamulapati, Kulbhushan Tikoo, Vaibhav Shrirang Dhawale
Publikováno v:
Journal of Biological Chemistry. 291:21848-21856
Recently, we have shown that high fat diet (HFD) in vivo and in vitro generates metabolic memory by altering H3K36me2 and H3K27me3 on the promoter of FOXO1 (transcription factor of gluconeogenic genes) (Kumar, S., Pamulapati, H., and Tikoo, K. (2016)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1f66f41a2c999f18fb6f8d4a5c0097
https://doi.org/10.1074/jbc.c116.732990
https://doi.org/10.1074/jbc.c116.732990
Autor:
Lena Kjellén, Audrey Deligny, Alison V. Nairn, Anders Lundequist, Tabea Dierker, Anders Dagälv, Catherine L.R. Merry, Inger Eriksson, Kelley W. Moremen
Publikováno v:
Journal of Biological Chemistry. 291:18600-18607
Analysis of heparan sulfate synthesized by HEK 293 cells overexpressing murine NDST1 and/or NDST2 demonstrated that the amount of heparan sulfate was increased in NDST2- but not in NDST1-overexpressing cells. Altered transcript expression of genes en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7de433ce16d909cdc032d8560290131
https://doi.org/10.1074/jbc.m116.744433
https://doi.org/10.1074/jbc.m116.744433
Publikováno v:
Journal of Biological Chemistry. 291:19725-19733
Depression is a significant public health problem for which currently available medications, if effective, require weeks to months of treatment before patients respond. Previous studies have shown that the G protein responsible for increasing cAMP (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b80e1f412804f6e1291dd12dc4ba8a
https://doi.org/10.1074/jbc.m116.727263
https://doi.org/10.1074/jbc.m116.727263