A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani

Autor: Shelton, Andrew B., Snider, Heidi, Varikuti, Sanjay, Naman, C. Benjamin, Gupta, Gaurav, Ainslie, Kristy M., Parinandi, Narasimham L., Fuchs, James R., Peine, Kevin J., Kotha, Sainath R., Kinghorn, A. Douglas, Satoskar, Abhay R., Pan, Li, Bachelder, Eric M., Huntsman, Andrew C., Oghumu, Steve, Papenfuss, Tracy L., Abdelhamid, Dalia, Rao, Latha

Visceral leishmaniasis (VL), caused by the protozoan parasite Leishmania donovani, is a global health problem affecting millions of people worldwide. Treatment of VL largely depends on therapeutic drugs such as pentavalent antimonials, amphotericin B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ad5a7e3eb107e9895116c22ba51bf18

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Autor: Gupta G; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States.; Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of Sao Paulo , Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, Brazil., Peine KJ; Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University , 484 West 12th Avenue, Columbus, Ohio 43210, United States.; Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina , 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Abdelhamid D; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.; Department of Medicinal Chemistry, Minia University , Minia, Egypt., Snider H; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States., Shelton AB; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Wexner Medical Center, The Ohio State University , 473 West 12th Avenue, Columbus, Ohio 43210, United States., Rao L; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Wexner Medical Center, The Ohio State University , 473 West 12th Avenue, Columbus, Ohio 43210, United States., Kotha SR; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Wexner Medical Center, The Ohio State University , 473 West 12th Avenue, Columbus, Ohio 43210, United States., Huntsman AC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Varikuti S; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States., Oghumu S; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States., Naman CB; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Pan L; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Parinandi NL; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Wexner Medical Center, The Ohio State University , 473 West 12th Avenue, Columbus, Ohio 43210, United States., Papenfuss TL; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University , 1900 Coffey Road, Columbus, Ohio 43210, United States.; Department of Pathology, WIL Research , Ashland, Ohio 55805, United States., Kinghorn AD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Bachelder EM; Division of Pharmaceutics, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.; Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina , 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Ainslie KM; Division of Pharmaceutics, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States.; Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina , 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , 500 West 12th Avenue, Columbus, Ohio 43210, United States., Satoskar AR; Department of Pathology, The Wexner Medical Center, The Ohio State University , 320 West 10th Avenue, Columbus, Ohio 43210, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2015 Oct 09; Vol. 1 (10), pp. 497-506. Date of Electronic Publication: 2015 Sep 21.