BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

Autor: Papathanassiu, AE, Ko, JH, Imprialou, M, Bagnati, M, Srivastava, PK, Vu, HA, Cucchi, D, McAdoo, SP, Ananieva, EA, Mauro, C, Behmoaras, JV

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors; however, the function of BCATs in macrophages is unknown. Here we show

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https://doaj.org/article/17c2e0ed5041454ca875e7539e4aa551

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BCAT1 is a NOTCH1 target and sustains the oncogenic function of NOTCH1.

Autor: Tosello V; Basic and Translational Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua., Di Martino L; Department of Surgery, Oncology and Gastroenterology, University of Padua., Papathanassiu AE; Ergon Pharmaceuticals, LLC, Washington DC, United States of America., Santa SD; Department of Surgery, Oncology and Gastroenterology, University of Padua., Pizzi M; Surgical Pathology and Cytopathology Unit, Department of Medicine - DIMED, University of Padua., Mussolin L; Unit of Onco-hematology, stem cell transplant and gene therapy, Department of Women's and Children's Health, University of Padua., Liu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN., Van Vlierberghe P; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Piovan E; Department of Surgery, Oncology and Gastroenterology, University of Padua; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua. erich.piovan@unipd.it.

Publikováno v: Haematologica [Haematologica] 2024 Sep 05. Date of Electronic Publication: 2024 Sep 05.

BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages.

Autor: Ko JH; Centre for Inflammatory Disease, Imperial College London, London W12 0NN, UK., Olona A; Centre for Inflammatory Disease, Imperial College London, London W12 0NN, UK., Papathanassiu AE; Ergon Pharmaceuticals, LLC, P.O. Box 1001, Silver Spring, MD 20910, USA jacques.behmoaras@imperial.ac.uk adoniap@ergon-pharmaceuticals.com., Buang N; Centre for Inflammatory Disease, Imperial College London, London W12 0NN, UK., Park KS; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA., Costa ASH; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Mauro C; Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Mindelsohn Way, Birmingham B15 2WB, UK., Frezza C; Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Behmoaras J; Centre for Inflammatory Disease, Imperial College London, London W12 0NN, UK jacques.behmoaras@imperial.ac.uk adoniap@ergon-pharmaceuticals.com.

Publikováno v: Journal of cell science [J Cell Sci] 2020 Nov 27; Vol. 133 (22). Date of Electronic Publication: 2020 Nov 27.