Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Papathanassiu, A."'
Autor:
Valeria Tosello, Ludovica Di Martino, Adonia E. Papathanassiu, Silvia Dalla Santa, Marco Pizzi, Lara Mussolin, Jingjing Liu, Pieter van Vlierberghe, Erich Piovan
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
High levels of branched-chain amino acid (BCAA) transaminase 1 (BCAT1) have been associated with tumor aggressiveness and drug resistance in several cancer types. Nevertheless, the mechanistic role of BCAT1 in T-cell acute lymphoblastic leukemia (T-A
Externí odkaz:
https://doaj.org/article/aa06b5c2432447d98b8c7c41b7f0c797
Autor:
L. Di Martino, V. Tosello, S. Dalla Santa, A. Papathanassiu, G. Arrigoni, P. van Vlierberghe, E. Piovan
Publikováno v:
HemaSphere, Vol 6, Pp 238-239 (2022)
Externí odkaz:
https://doaj.org/article/10073128dd3b46b7bba442bd92ec3053
Autor:
Adonia E. Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K. Srivastava, Hong A. Vu, Danilo Cucchi, Stephen P. McAdoo, Elitsa A. Ananieva, Claudio Mauro, Jacques Behmoaras
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulon
Externí odkaz:
https://doaj.org/article/17c2e0ed5041454ca875e7539e4aa551
Autor:
Francesca Lodi, Michelangelo Certo, Hagar Elkafrawy, Weixing Li, Hong A. Vu, Konstantin Gilbo, Li Su, Ian L. Pegg, Tobias Weiss, Marcel Bühler, Michael Weller, Charles Yeh, Jacob E. Corn, Kwon-Sik Park, Jeong-Hun Ko, Jacques Behmoaras, Claudio Mauro, Diether Lambrechts, Adonia E. Papathanassiu
The present study explores the role of the cytosolic branched chain amino acid aminotransferase (BCAT1) in CD8+T cell activation, in general, and tumor immunity, in particular, and identifies a non-canonical function of the protein in iron homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41992241eae6ac3447e68d05b16c9b4b
https://doi.org/10.1101/2023.02.25.530034
https://doi.org/10.1101/2023.02.25.530034
Akademický článek
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Publikováno v:
Cancer Research. 82:4236-4236
We have previously demonstrated that BCAT1, the enzyme responsible for the reversible transamination of leucine in the cytosol, is a druggable target in immune-oncology: the small molecule inhibitor ERG245 dramatically increases the efficacy of anti-
Akademický článek
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Publikováno v:
Cancer Research. 81:1202-1202
Immune responsive gene 1 (Irg1) is an LPS-inducible gene within macrophages (MF) whose protein product is responsible for the synthesis of itaconate from aconitate through a break in the TCA cycle. Although primarily present in proinflammatory macrop
Autor:
Papathanassiu, AE, Ko, JH, Imprialou, M, Bagnati, M, Srivastava, PK, Vu, HA, Cucchi, D, McAdoo, SP, Ananieva, EA, Mauro, C, Behmoaras, JV
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors; however, the function of BCATs in macrophages is unknown. Here we show