Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

Autor: Wong, Raymond, Lénárt, Nikolett, Hill, Laura, Toms, Lauren, Martinecz, Bernadett, Császár, Eszter, Nyiri, Gábor, Papaemmanouil, Athina, Waisman, Ari, Muller, Werner, Schwaninger, Markus, Rothwell, Nancy, Francis, Sheila, Pinteaux, Emmanuel, Denes, Adam, Allan, Stuart

Publikováno v: Wong, R, Lénárt, N, Hill, L, Toms, L, Martinecz, B, Császár, E, Nyiri, G, Papaemmanouil, A, Waisman, A, Muller, W, Schwaninger, M, Rothwell, N, Francis, S, Pinteaux, E, Denes, A & Allan, S 2018, ' Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons ', Brain, Behavior, and Immunity, vol. 76, 0, pp. 126-138 . https://doi.org/10.1016/j.bbi.2018.11.012

The cytokine interleukin-1 (IL-1) is a key contributor to neuroinflammation and brain injury, yet mechanisms by which IL-1 triggers neuronal injury remain unknown. Here we induced conditional deletion of IL-1R1 in brain endothelial cells, neurons and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::b60c75632a8ccb32e97ee3e2db5c41cf
https://www.research.manchester.ac.uk/portal/en/publications/interleukin1-mediates-ischaemic-brain-injury-via-distinct-actions-on-endothelial-cells-and-cholinergic-neurons(9b94aa9e-063d-4d5f-aaf6-c4c130c9244c).html

Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system.

Autor: Abdulaal, Wesam H., Walker, Catherine R., Costello, Ryan, Redondo‐Castro, Elena, Mufazalov, Ilgiz A., Papaemmanouil, Athina, Rothwell, Nancy J., Allan, Stuart M., Waisman, Ari, Pinteaux, Emmanuel, Müller, Werner

Publikováno v: European Journal of Immunology; Apr2016, Vol. 46 Issue 4, p912-918, 7p

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