The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer

Autor: Audet-Walsh, Étienne, Papadopoli, David J., Gravel, Simon-Pierre, Yee, Tracey, Bridon, Gaëlle, Caron, Maxime, Bourque, Guillaume, Giguère, Vincent, St-Pierre, Julie

Publikováno v: In Cell Reports 2 February 2016 14(4):920-931

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PGC-1α supports glutamine metabolism in breast cancer.

Autor: McGuirk S; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Department of Biochemistry, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada., Gravel SP; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Department of Biochemistry, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada., Deblois G; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Department of Biochemistry, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada., Papadopoli DJ; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Department of Biochemistry, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada., Faubert B; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Department of Physiology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada., Wegner A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts-Fourneaux, Esch-Belval L-4362, Luxembourg., Hiller K; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts-Fourneaux, Esch-Belval L-4362, Luxembourg., Avizonis D; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Metabolomics Core Facility, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada., Akavia UD; Department of Biochemistry, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada.; Department of Biological Sciences, Columbia University, 1212 Amsterdam Ave, New York, NY 10027, USA.; Center for Computational Biology and Bioinformatics, Columbia University Medical Center, 1130 St. Nicholas Ave, New York, NY 10032, USA., Jones RG; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Department of Physiology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada., Giguère V; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Department of Biochemistry, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada., St-Pierre J; Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montréal, PQ H3A 1A3, Canada.; Department of Biochemistry, McGill University, 3655 Promenade Sir-William-Osler, Montréal, PQ H3G 1Y6, Canada.

Publikováno v: Cancer & metabolism [Cancer Metab] 2013 Dec 05; Vol. 1 (1), pp. 22. Date of Electronic Publication: 2013 Dec 05.