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Autor:
Paoni, N. F., Lowe, D. G.
Publikováno v:
Trends in Cardiovascular Medicine; 2001, Vol. 11 Issue: 6 p218-221, 4p
Autor:
Pennica, D, Shaw, K J, Swanson, T A, Moore, M W, Shelton, D L, Zioncheck, K A, Rosenthal, A, Taga, T, Paoni, N F, Wood, W I
Publikováno v:
Journal of Biological Chemistry; May 1995, Vol. 270 Issue: 18 p10915-22, 8p
Autor:
Paoni, N F, Koshland, D E
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; August 1979, Vol. 76 Issue: 8 p3693-3697, 5p
Autor:
Keyt, B A, Paoni, N F, Refino, C J, Berleau, L, Nguyen, H, Chow, A, Lai, J, Peña, L, Pater, C, Ogez, J
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; April 1994, Vol. 91 Issue: 9 p3670-3674, 5p
Autor:
Bennett, W F, Paoni, N F, Keyt, B A, Botstein, D, Jones, A J, Presta, L, Wurm, F M, Zoller, M J
Publikováno v:
Journal of Biological Chemistry; March 1991, Vol. 266 Issue: 8 p5191-5201, 11p
Autor:
Paoni, N. F., Keyt, B. A., Refino, C. J., Chow, A. M., Nguyen, H. V., Berleau, L. T., Badillo, J., Pena, L. C., Brady, K., Wurm, F. M.
Site directed mutagenesis was used to construct a t-PA variant that contains an additional glycosylation site in the first kringle domain (T103N) combined with a tetra-alanine substitution in the protease domain (KHRR 296-299 AAAA). This combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______185::9855b76a794c12294b3b80513ec55e77
https://infoscience.epfl.ch/record/105005
https://infoscience.epfl.ch/record/105005
Autor:
Paoni, N. F., Refino, C. J., Brady, K., Pena, L. C., Nguyen, H. V., Kerr, E. M., Johnson, A. C., Wurm, F. M., van Reis, R., Botstein, D.
The tetra-alanine substitution variant KHRR 296-299 AAAA of tissue-type plasminogen activator (t-PA) was previously shown to have enhanced fibrin specificity and enhanced activity in the presence of fibrin compared with the wild-type form of the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______185::cbc6d373641e88159133112e330c9987
https://infoscience.epfl.ch/record/105002
https://infoscience.epfl.ch/record/105002
Autor:
Refino, C. J., Paoni, N. F., Keyt, B. A., Pater, C. S., Badillo, J. M., Wurm, F. M., Ogez, J., Bennett, W. F.
In the accompanying paper, we reported that the properties of decreased plasma clearance rate, increased fibrin specificity, and resistance to inactivation by PAI-1 could be effectively combined in the t-PA variant T103N, KHRR 296-299 AAAA. In the cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______185::386a525d063033b35427e4cd50f2dc54
https://infoscience.epfl.ch/record/105001
https://infoscience.epfl.ch/record/105001
Autor:
Bennett, W. F., Paoni, N. F., Keyt, B. A., Botstein, D., Jones, A. J., Presta, L., Wurm, F. M., Zoller, M. J.
Sixty-four variants of human tissue-type plasminogen activator (tPA) were produced using recombinant DNA techniques. Charged residues were converted to alanine in clusters of from one to four changes per variant; these clusters spanned all the domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______185::ceb2b6017747744a659974e4ff03f859
https://infoscience.epfl.ch/record/104994
https://infoscience.epfl.ch/record/104994