Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Paolo Zatta"'
Effects of a copper-deficient diet on the biochemistry, neural morphology and behavior of aged mice.
Autor:
Silvia Bolognin, Federica Pasqualetto, Carla Mucignat-Caretta, Janez Scancar, Radmila Milacic, Pamela Zambenedetti, Bruno Cozzi, Paolo Zatta
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47063 (2012)
Copper dyshomeostasis has been suggested as an aetiological risk factor for some neurodegenerative diseases, such as Alzheimer's disease. However, the precise mechanism at the base of this involvement is still obscure. In this work, we show the effec
Externí odkaz:
https://doaj.org/article/495f39ac38b84853a814befeb7ac3ddd
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Externí odkaz:
https://doaj.org/article/9878978188b74169ba5c1d2054ac9636
Autor:
Alberto Granzotto, Paolo Zatta
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21565 (2011)
It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggr
Externí odkaz:
https://doaj.org/article/fe94cf77a5ab4a4ab66c5775dc5817c9
Autor:
Valentina Gatta, Denise Drago, Karina Fincati, Maria Teresa Valenti, Luca Dalle Carbonare, Stefano L Sensi, Paolo Zatta
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15965 (2011)
BACKGROUND: A typical pathological feature of Alzheimer's disease (AD) is the appearance in the brain of senile plaques made up of β-amyloid (Aβ) and neurofibrillary tangles. AD is also associated with an abnormal accumulation of some metal ions, a
Externí odkaz:
https://doaj.org/article/880f08e1a8214571882c7a694eb8e7fc
Autor:
Paolo Zatta
Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to thei
Autor:
Paolo Zatta
Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidat
Publikováno v:
Neurochemistry International. 62:566-574
Several lines of evidence have supported the potential involvement of metal ions in the etiology of Alzheimer’s Disease (AD). However, the molecular mechanisms underlying this interaction are still partially unknown. Previous work from our laborato
Autor:
Denise Drago, Silvia Bolognin, Paolo Zatta, Stefano L. Sensi, Valentina Gatta, Alberto Granzotto, Karina Fincati
Publikováno v:
Future Neurology. 7:483-497
Aims: Abnormal metal accumulation is associated with Alzheimer’s disease and plays a relevant role in affecting amyloid-β (Aβ) peptide aggregation and neurotoxicity. Material & Methods: In the present study, employing a microarray analysis of 35,
Publikováno v:
JOURNAL OF INORGANIC BIOCHEMISTRY
Artículos CONICYT
CONICYT Chile
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Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Alzheimer's disease is one of the most common forms of dementia in the elderly. One of its hallmarks is the abnormal aggregation and deposition of β-amyloid (Aβ). Endogenous and exogenous metal ions seem to influence β-amyloid folding process, agg
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 142:421-430
Alzheimer’s disease is a multifactorial neurodegenerative disorder characterized by the pathological brain deposition of neurofibrillary tangles and senile plaques. The latter consist mainly of insoluble β-amyloid (Aβ) fibril deposition. Aβ aggr