Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Paolo V. Pedone"'
Autor:
Nicola Landi, Vincenza Ciaramella, Sara Ragucci, Angela Chambery, Fortunato Ciardiello, Paolo V. Pedone, Teresa Troiani, Antimo Di Maro
Publikováno v:
Toxins, Vol 15, Iss 1, p 57 (2023)
Cetuximab is a monoclonal antibody blocking the epidermal growth factor receptor (EGFR) in metastatic colorectal cancer (mCRC). However, cetuximab treatment has no clinical benefits in patients affected by mCRC with KRAS mutation or in the presence o
Externí odkaz:
https://doaj.org/article/9a09573074fd400b8851133f7ddeb361
Publikováno v:
Toxins, Vol 14, Iss 6, p 403 (2022)
rRNA N-glycosylases (EC 3.2.2.22) remove a specific adenine (A4324, rat 28S rRNA) in the sarcin ricin loop (SRL) involved into ribosome interaction with elongation factors, causing the inhibition of translation, for which they are known as plant ‘r
Externí odkaz:
https://doaj.org/article/db1d3312cf994ccea6f3ae4c1620adf1
Autor:
Rossella Rotondo, Sara Ragucci, Salvatore Castaldo, Nicola Landi, Maria Antonietta Oliva, Paolo V. Pedone, Antimo Di Maro, Antonietta Arcella
Publikováno v:
Molecules, Vol 27, Iss 8, p 2385 (2022)
Here, we propose Ageritin, the prototype of the ribotoxin-like protein family, as an adjuvant treatment to control the growth of NULU and ZAR, two primary human glioblastoma cell lines, which exhibit a pharmacoresistance phenotype. Ageritin is able t
Externí odkaz:
https://doaj.org/article/243dbeb3c4154dbcbcbaa98321cb5f53
Publikováno v:
Toxins, Vol 14, Iss 2, p 84 (2022)
Here, we report the current status of the bioactive peptides isolated and characterized from mushrooms during the last 20 years, considering ‘peptide’ a succession from to 2 to 100 amino acid residues. According to this accepted biochemical defin
Externí odkaz:
https://doaj.org/article/974f077175ac4df2870587f0b7889969
Autor:
Rossella Rotondo, Sara Ragucci, Salvatore Castaldo, Maria Antonietta Oliva, Nicola Landi, Paolo V. Pedone, Antonietta Arcella, Antimo Di Maro
Publikováno v:
Toxins, Vol 13, Iss 10, p 684 (2021)
Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cell
Externí odkaz:
https://doaj.org/article/8d52fb8350494b4b8dd7339bfa4a3caf
Autor:
Alexander P. Sobinoff, Salvatore Di Maro, Ronnie R. J. Low, Rosaria Benedetti, Stefano Tomassi, Antonia D’Aniello, Rosita Russo, Ilaria Baglivo, Ugo Chianese, Paolo V. Pedone, Angela Chambery, Anthony J. Cesare, Lucia Altucci, Hilda A. Pickett, Sandro Cosconati
The shelterin component telomeric repeat-binding factor 2 (TRF2) is an essential regulator of telomere homeostasis and genomic stability. Mutations in the TRF2TRFHdomain physically impair t-loop formation and prevent the recruitment of several factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::429618ff1a159961061e4b07ab2d7e6e
https://doi.org/10.1101/2023.02.01.526591
https://doi.org/10.1101/2023.02.01.526591
Autor:
Martina Dragone, Rinaldo Grazioso, Gianluca D’Abrosca, Ilaria Baglivo, Rosa Iacovino, Sabrina Esposito, Antonella Paladino, Paolo V. Pedone, Luigi Russo, Roberto Fattorusso, Gaetano Malgieri, Carla Isernia
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11010
A strict interplay is known to involve copper and zinc in many cellular processes. For this reason, the results of copper’s interaction with zinc binding proteins are of great interest. For instance, copper interferences with the DNA-binding activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc497f667030d8369e691a8b0f142a2
https://pubmed.ncbi.nlm.nih.gov/36232306
https://pubmed.ncbi.nlm.nih.gov/36232306
Autor:
Nicola Landi, Maja Grundner, Sara Ragucci, Miha Pavšič, Martina Mravinec, Paolo V. Pedone, Kristina Sepčić, Antimo Di Maro
Publikováno v:
Food chemistry. 396
Ribotoxin-like proteins (RL-Ps) represent a novel specific ribonuclease family found in edible mushrooms and are able to inhibit protein synthesis. Here, we report the characterization and cytotoxic effects of four novel RL-Ps, named eryngitins, isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f474580025938cb996a538e1a951f8
https://pubmed.ncbi.nlm.nih.gov/35868286
https://pubmed.ncbi.nlm.nih.gov/35868286
Autor:
Maria Antonietta Oliva, Antonietta Arcella, Paolo V. Pedone, Salvatore Castaldo, Antimo Di Maro, Nicola Landi, Rossella Rotondo, Sara Ragucci
Publikováno v:
Toxins
Volume 13
Issue 10
Toxins, Vol 13, Iss 684, p 684 (2021)
Volume 13
Issue 10
Toxins, Vol 13, Iss 684, p 684 (2021)
Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d808157398ce99a67dbf2d1d44323b
https://pubmed.ncbi.nlm.nih.gov/34678977
https://pubmed.ncbi.nlm.nih.gov/34678977
Autor:
Rosita Russo, Antimo Di Maro, Mariangela Valletta, Nicola Landi, Paolo V. Pedone, Sara Ragucci, Angela Chambery
Publikováno v:
Toxins, Vol 13, Iss 263, p 263 (2021)
Toxins
Toxins
Ageritin is a specific ribonuclease, extracted from the edible mushroom Cyclocybe aegerita (synonym Agrocybe aegerita), which cleaves a single phosphodiester bond located within the universally conserved alpha-sarcin loop (SRL) of 23–28S rRNAs. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c96bed921b2657909255baa70c55f20
https://pubmed.ncbi.nlm.nih.gov/33917246
https://pubmed.ncbi.nlm.nih.gov/33917246