Výsledky vyhledávání - "Paolo Scarpelli"

Akademický článek

GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated HepatitisSummary

Autor: Michele Biagioli, Adriana Carino, Chiara Fiorucci, Silvia Marchianò, Cristina Di Giorgio, Rosalinda Roselli, Margherita Magro, Eleonora Distrutti, Oxana Bereshchenko, Paolo Scarpelli, Angela Zampella, Stefano Fiorucci

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 447-473 (2019)

Background & Aims: GPBAR1, also known as TGR5, is a G protein–coupled receptor activated by bile acids. Hepatic innate immune cells are involved in the immunopathogenesis of human liver diseases and in several murine hepatitis models. Here, by usin

Externí odkaz: https://doaj.org/article/c0cc2e5bfe5240be8e530d1f9ce3a25e

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Akademický článek

Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis

Autor: Samuele Sabbatini, Claudia Monari, Nathalie Ballet, Paolo Mosci, Amélie Cayzeele Decherf, Fanny Pélerin, Stefano Perito, Paolo Scarpelli, Anna Vecchiarelli

Publikováno v: Virulence, Vol 9, Iss 1, Pp 954-966 (2018)

In this study, we demonstrate, for the first time, that Saccharomyces cerevisiae-based probiotic shows an inhibitory effect on Gardnerella vaginalis infection. This effect is likely due to several actions: direct interference with adherence to vagina

Externí odkaz: https://doaj.org/article/b97cd257ed554951ac56804fbee9e91a

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Akademický článek

Metabolic Variability of a Multispecies Probiotic Preparation Impacts on the Anti-inflammatory Activity

Autor: Michele Biagioli, Luca Laghi, Adriana Carino, Sabrina Cipriani, Eleonora Distrutti, Silvia Marchianò, Carola Parolin, Paolo Scarpelli, Beatrice Vitali, Stefano Fiorucci

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Background: In addition to strain taxonomy, the ability of probiotics to confer beneficial effects on the host rely on a number of additional factors including epigenetic modulation of bacterial genes leading to metabolic variability and might impact

Externí odkaz: https://doaj.org/article/bebd7640111e41678dca7df3f42fc674

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Akademický článek

Coadministration of isavuconazole and sirolimus in allogeneic hematopoietic stem cell transplant recipients

Publikováno v: Therapeutic Advances in Infectious Disease, Vol 11 (2024)

Background: Invasive fungal infections (IFIs) represent a major cause of morbidity among allogeneic hematopoietic stem cell transplantation (allo-HSCT). Isavuconazole (ISA) is a broad-spectrum triazole with favorable safety profile. Objectives and de

Externí odkaz: https://doaj.org/article/c46106222e2e48b898e1817e92e8c2d5

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Amniotic fluid stem cell-derived extracellular vesicles are independent metabolic units capable of modulating inflammasome activation in THP-1 cells

Autor: Letizia Mezzasoma, Ilaria Bellezza, Pierluigi Orvietani, Giorgia Manni, Marco Gargaro, Krizia Sagini, Alicia Llorente, Paolo Scarpelli, Luisa Pascucci, Barbara Cellini, Vincenzo Nicola Talesa, Francesca Fallarino, Rita Romani

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(4)

An immunoregulatory role of stem cells, often mediated by their secretome, has been claimed by several studies. Stem cell-derived extracellular vesicles (EVs) are crucial components of the secretome. EVs, a heterogeneous group of membranous vesicles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa3861d830b8d365a3a434341a82016
https://pubmed.ncbi.nlm.nih.gov/35218567

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GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated HepatitisSummary

Autor: Eleonora Distrutti, Cristina Di Giorgio, Oxana Bereshchenko, Margherita Magro, Michele Biagioli, Stefano Fiorucci, Rosalinda Roselli, Paolo Scarpelli, Angela Zampella, Silvia Marchianò, Adriana Carino, Chiara Fiorucci

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 447-473 (2019)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims GPBAR1, also known as TGR5, is a G protein–coupled receptor activated by bile acids. Hepatic innate immune cells are involved in the immunopathogenesis of human liver diseases and in several murine hepatitis models. Here, by using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd5fdd397332e775f4d6df68ddcf48a
http://www.sciencedirect.com/science/article/pii/S2352345X19300815

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Cyclo(His-Pro) inhibits NLRP3 inflammasome cascade in ALS microglial cells

Autor: Ilaria Bellezza, Ivana Cacciatore, Barbara Cellini, Paolo Scarpelli, Silvia Grottelli, Letizia Mezzasoma

Publikováno v: Molecular and Cellular Neuroscience. 94:23-31

Neuroinflammation, i.e. self-propelling progressive cycle of microglial activation and neuron damage, as well as improper protein folding, are recognized as major culprits of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97832f4b6d1f635b2d78f870eeaba5a6
https://doi.org/10.1016/j.mcn.2018.11.002

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Clostridium difficile toxin B induces senescence in enteric glial cells: A potential new mechanism of Clostridium difficile pathogenesis

Autor: Andrea Marchegiani, Matteo Cerquetella, Gabrio Bassotti, Paolo Scarpelli, Camilla Palumbo, Magdalena Davidescu, Katia Fettucciari, Pierfrancesco Marconi, Andrea Spaterna, Lanfranco Corazzi, Lara Macchioni

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:1945-1958

Clostridium difficile infection (CDI) causes nosocomial/antibiotic-associated diarrhea and pseudomembranous colitis, with dramatic incidence/mortality worldwide. C. difficile virulence factors are toxin A and toxin B (TcdB) which cause cytopathic/cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df35a95eee00f67f868fd3ed893b5700
https://doi.org/10.1016/j.bbamcr.2018.10.007

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The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy

Autor: Cristina Di Giorgio, Eleonora Distrutti, Maria Chiara Monti, Angela Zampella, Paolo Scarpelli, Michele Biagioli, Martina Bordoni, Stefano Fiorucci, Adriana Carino, Rosalinda Roselli, Chiara Fiorucci, Silvia Marchianò

Publikováno v: The FASEB Journal. 35

Autophagy is a highly conserved catabolic process activated by fasting and caloric restriction. FXR, a receptor for primary bile acids, reverses the activity of cAMP-response element binding protein (CREB) on autophagy-related genes (Atg)s and termin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43f3b6420f2a277f8e4a24546fa397f
https://doi.org/10.1096/fj.202001386r

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Extracellular Vesicles-Mediated Transfer of miRNA Let-7b from PC3 Cells to Macrophages

Autor: Rita Romani, Paolo Scarpelli, Egidia Costanzi, Ilaria Bellezza

Publikováno v: Genes
Volume 11
Issue 12
Genes, Vol 11, Iss 1495, p 1495 (2020)

Prostate-derived extracellular vesicles (pEVs) may represent a way to selectively transport cargo molecules from the producing cells to the target cells to allow biological events, both in physiological and pathological circumstances. pEVs cargo part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe71eb0c90edc459d5120048d9e2596

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