Výsledky vyhledávání - "Paolo Salomoni"

Akademický článek

Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice

Autor: Kan Xie, Helmut Fuchs, Enzo Scifo, Dan Liu, Ahmad Aziz, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Patricia da Silva-Buttkus, Julia Calzada-Wack, Yi-Li Cho, Yushuang Deng, A. Cole Edwards, Lillian Garrett, Christina Georgopoulou, Raffaele Gerlini, Sabine M. Hölter, Tanja Klein-Rodewald, Michael Kramer, Stefanie Leuchtenberger, Dimitra Lountzi, Phillip Mayer-Kuckuk, Lena L. Nover, Manuela A. Oestereicher, Clemens Overkott, Brandon L. Pearson, Birgit Rathkolb, Jan Rozman, Jenny Russ, Kristina Schaaf, Nadine Spielmann, Adrián Sanz-Moreno, Claudia Stoeger, Irina Treise, Daniele Bano, Dirk H. Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Beverly A. Mock, Paolo Salomoni, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Monique M. B. Breteler, Martin Hrabě de Angelis, Dan Ehninger

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-29 (2022)

Lifespan can be affected by both physiological ageing and specific sets of pathologies associated with old age. Here the authors report a resource of large-scale cross-sectional phenotyping of aging male mice at different time points to analyse a lar

Externí odkaz: https://doaj.org/article/0113605e46d14b5694c7bb3ab07c1fa9

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Akademický článek

Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

Autor: Stefanie Meier, Sandra Cantilena, Maria Victoria Niklison Chirou, John Anderson, Darren Hargrave, Paolo Salomoni, Jasper de Boer, David Michod

Publikováno v: Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)

Abstract Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-grade gliomas are often resistant to therapy and associated with a poor outcome, children with low-grade gliomas face a better prognosis. However,

Externí odkaz: https://doaj.org/article/37b9b311637f454da4bee76f6dda33bb

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Akademický článek

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Lysine27-to-methionine mutations in histone H3 genes (H3K27M) occur in a subgroup of gliomas and decrease genome-wide H3K27 trimethylation. Here the authors utilise primary H3K27M tumour lines and isogenic CRISPR-edited controls and show that H3K27M

Externí odkaz: https://doaj.org/article/0beae741fed94f66b31dab929cbfe1ba

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Akademický článek

A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS

Publikováno v: Cell Reports, Vol 20, Iss 2, Pp 411-426 (2017)

Cell migration through the brain parenchyma underpins neurogenesis and glioblastoma (GBM) development. Since GBM cells and neuroblasts use the same migratory routes, mechanisms underlying migration during neurogenesis and brain cancer pathogenesis ma

Externí odkaz: https://doaj.org/article/873f21f75568412b94335f35aa49c606

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Akademický článek

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

Autor: Antonia Piazzesi, Dražen Papić, Fabio Bertan, Paolo Salomoni, Pierluigi Nicotera, Daniele Bano

Publikováno v: Cell Reports, Vol 17, Iss 4, Pp 987-996 (2016)

Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the imp

Externí odkaz: https://doaj.org/article/986e7b2434224eb1a16080a7b081b371

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