Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paolo Pizzul"'
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110373- (2024)
Summary: Homologous recombination is initiated by the nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection is a two-step process. In the short-range step, the MRX (Mre11-Rad50-Xrs2) complex, together with Sae2, incise
Externí odkaz:
https://doaj.org/article/005a8cfcaad84c2196cb2a5f63050469
Autor:
Erika Casari, Paolo Pizzul, Carlo Rinaldi, Marco Gnugnoli, Michela Clerici, Maria Pia Longhese
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113360- (2023)
Summary: DNA damage elicits a checkpoint response depending on the Mec1/ATR kinase, which detects the presence of single-stranded DNA and activates the effector kinase Rad53/CHK2. In Saccharomyces cerevisiae, one of the signaling circuits leading to
Externí odkaz:
https://doaj.org/article/e5a235e7d82741c1906f75bd2f41209b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Replicative senescence is an essential cellular process playing important physiological functions, but it is better known for its implications in aging, cancer, and other pathologies. One of the main triggers of replicative senescence is telomere sho
Externí odkaz:
https://doaj.org/article/2ff000631ee54863b1077de7d7a55039
Autor:
Paolo Pizzul, Erika Casari, Marco Gnugnoli, Carlo Rinaldi, Flavio Corallo, Maria Pia Longhese
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Studies performed in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have led the way in defining the DNA damage checkpoint and in identifying most of the proteins involved in this regulatory network, which turned out to have struct
Externí odkaz:
https://doaj.org/article/5f64489a026446b5874afaa79be51d82
Autor:
Erika Casari, Marco Gnugnoli, Carlo Rinaldi, Paolo Pizzul, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Publikováno v:
Cells, Vol 11, Iss 20, p 3224 (2022)
Early work by Muller and McClintock discovered that the physical ends of linear chromosomes, named telomeres, possess an inherent ability to escape unwarranted fusions. Since then, extensive research has shown that this special feature relies on spec
Externí odkaz:
https://doaj.org/article/79fd461168b14762b39a5c02ee1060b7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the nascent RNA strongly binds the template DNA strand, l
Externí odkaz:
https://doaj.org/article/69ad709bd68c4433b77b95de79917b07
Autor:
Carlo Rinaldi, Paolo Pizzul, Erika Casari, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese
DNA double-strand breaks (DSBs) can be repaired by either homologous recombination (HR) or non-homologous end-joining (NHEJ). NHEJ is induced by the binding to DSBs of the Ku70–Ku80 heterodimer, which acts as a hub for the recruitment of downstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca28852cf333276a0bab7c708962f388
https://hdl.handle.net/10281/403662
https://hdl.handle.net/10281/403662
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the nascent RNA strongly binds the template DNA strand, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da9dadd2a6e1e8cbd2a15054da0aa62
https://pubmed.ncbi.nlm.nih.gov/33505970
https://pubmed.ncbi.nlm.nih.gov/33505970
Autor:
Jacopo Vertemara, Renata Tisi, Diego Bonetti, Marco Notaro, Giuseppe Zampella, Paolo Pizzul, Carlo Rinaldi, Maria Pia Longhese
Publikováno v:
Nucleic Acids Research
The cellular response to DNA double-strand breaks (DSBs) is initiated by the Mre11–Rad50–Xrs2 (MRX) complex that has structural and catalytic functions. MRX association at DSBs is counteracted by Rif2, which is known to interact with Rap1 that bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc20ce4402d07d2d82ce6883e82dd4b
http://hdl.handle.net/10281/257213
http://hdl.handle.net/10281/257213