Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Paolo Pigini"'
Autor:
Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah‐Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai‐Hua Chow
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Deregulation of MYC is among the most frequent oncogenic drivers in hepatocellular carcinoma (HCC). Unfortunately, the clinical success of MYC‐targeted therapies is limited. Synthetic lethality offers an alternative therapeutic strategy by
Externí odkaz:
https://doaj.org/article/77b9e0909c8e44a4a3b1672a0d0ade9b
Autor:
Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M. Koh, Laura Hulea, Paolo Pigini, Federico Di Tullio, Giuseppe Andreacchio, Michal Marek Hoppe, Heike Wollmann, Diana Low, Matias J. Caldez, Yanfen Peng, Denis Torre, Julia N. Zhao, Oro Uchenunu, Gabriele Varano, Corina-Mihaela Motofeanu, Manikandan Lakshmanan, Shun Xie Teo, Cheng Mun Wun, Giovanni Perini, Soo Yong Tan, Chee Bing Ong, Muthafar Al-Haddawi, Ravisankar Rajarethinam, Susan Swee-Shan Hue, Soon Thye Lim, Choon Kiat Ong, Dachuan Huang, Siok-Bian Ng, Emily Bernstein, Dan Hasson, Keng Boon Wee, Philipp Kaldis, Anand Jeyasekharan, David Dominguez-sola, Ivan Topisirovic, Ernesto Guccione
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which
Externí odkaz:
https://doaj.org/article/9df5fd5400ec47e98903d3b9c0b42cbb
Autor:
Laura D. Gamble, Stefania Purgato, Michelle J. Henderson, Simone Di Giacomo, Amanda J. Russell, Paolo Pigini, Jayne Murray, Emanuele Valli, Giorgio Milazzo, Federico M. Giorgi, Mark Cowley, Lesley J. Ashton, Jaydutt Bhalshankar, Gudrun Schleiermacher, Ali Rihani, Tom Van Maerken, Jo Vandesompele, Frank Speleman, Rogier Versteeg, Jan Koster, Angelika Eggert, Rosa Noguera, Raymond L. Stallings, Gian Paolo Tonini, Kwun Fong, Zalman Vaksman, Sharon J. Diskin, John M. Maris, Wendy B. London, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Giovanni Perini, Murray D. Norris, Michelle Haber
Publikováno v:
Cancers, Vol 13, Iss 8, p 1807 (2021)
Ornithine decarboxylase (ODC1), a critical regulatory enzyme in polyamine biosynthesis, is a direct transcriptional target of MYCN, amplification of which is a powerful marker of aggressive neuroblastoma. A single nucleotide polymorphism (SNP), G316A
Externí odkaz:
https://doaj.org/article/d53bfb862d414aec9d647c76d3457b58
Autor:
Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah‐Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai‐Hua Chow
Publikováno v:
Bioengineering & Translational Medicine. 8
Autor:
null Dexter Kai Hao Thng, null Tan Boon Toh, null Paolo Pigini, null Lissa Hooi, null Yock Young Dan, null Pierce Kah‐Hoe Chow, null Glenn Kunnath Bonney, null Masturah Bte Mohd Abdul Rashid, null Ernesto Guccione, null Dave Keng Boon Wee, null Edward Kai‐Hua Chow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fcf5963476ed0f15b64a12d6c87807d
https://doi.org/10.1002/btm2.10363/v2/response1
https://doi.org/10.1002/btm2.10363/v2/response1
Autor:
Heike Wollmann, David Papadopoli, Ravisankar Rajarethinam, Giovanni Perini, Michal Marek Hoppe, Laura Hulea, Soo Yong Tan, Emily Bernstein, Susan Swee Shan Hue, Choon Kiat Ong, Siok Bian Ng, Soon Thye Lim, Slim Mzoughi, Cheryl M. Koh, Ivan Topisirovic, Federico Di Tullio, Manikandan Lakshmanan, Corina Mihaela Motofeanu, Ernesto Guccione, Cheng Mun Wun, Oro Uchenunu, Chee Bing Ong, David Dominguez-Sola, Shun Xie Teo, Diana Low, Giuseppe Andreacchio, Gabriele Varano, Dachuan Huang, Muthafar Al-Haddawi, Paolo Pigini, Denis Torre, Y Peng, Anand D. Jeyasekharan, Julia N. Zhao, Philipp Kaldis, Jia Yi Fong, Matias J. Caldez, Keng Boon Wee, Dan Hasson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its lo
Autor:
Rogier Versteeg, Gian Paolo Tonini, Gudrun Schleiermacher, Amanda J. Russell, Angelika Eggert, Murray D. Norris, Jaydutt Bhalshankar, Michael D. Hogarty, Tom Van Maerken, Glenn M. Marshall, Mark J. Cowley, Kwun M. Fong, Lesley J. Ashton, John M. Maris, Sharon J. Diskin, Michelle Haber, Jayne Murray, Michelle J. Henderson, Stefania Purgato, Raymond L. Stallings, Jan Koster, Paolo Pigini, Ali Rihani, Zalman Vaksman, Jo Vandesompele, Wendy B. London, Rosa Noguera, Emanuele Valli, Laura D. Gamble, Franki Speleman, Federico M. Giorgi, Giovanni Perini, Giorgio Milazzo, Simone Di Giacomo, David S. Ziegler
Publikováno v:
Cancers, 13(8):1807. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Cancers, Vol 13, Iss 1807, p 1807 (2021)
Volume 13
Issue 8
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
CANCERS
Cancers
Cancers, Vol 13, Iss 1807, p 1807 (2021)
Volume 13
Issue 8
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
CANCERS
Simple Summary Neuroblastoma is a devasting childhood cancer in which multiple copies (amplification) of the cancer-causing gene MYCN strongly predict poor outcome. Neuroblastomas are reliant on high levels of cellular components called polyamines fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4917908fda62bba8644d6ef88dfa1048
https://pure.amc.nl/en/publications/a-g316a-polymorphism-in-the-ornithine-decarboxylase-gene-promoter-modulates-mycndriven-childhood-neuroblastoma(a76771d0-831a-4b04-9af8-31acd810ac62).html
https://pure.amc.nl/en/publications/a-g316a-polymorphism-in-the-ornithine-decarboxylase-gene-promoter-modulates-mycndriven-childhood-neuroblastoma(a76771d0-831a-4b04-9af8-31acd810ac62).html
Autor:
Murray D. Norris, Paolo Pigini, Roberto Bernardoni, F. Ferrucci, Michelle Haber, Giorgio Milazzo, Sara Monticelli, S. Di Giacomo, Daniela Erriquez, Roberto Ciaccio, Stefania Purgato, Giovanni Perini
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1863:194645
Autor:
C. Scotton, H. Osman, Alessandra Recchia, Lucia Morandi, Alessandra Ferlini, Marcella Neri, Pia Bernasconi, Paolo Pigini, Lorenzo Maggi, Chiara Passarelli, Matteo Bovolenta, Marina Mora, Annarita Armaroli, Maria Sofia Falzarano, Samuele Gherardi, Rita Selvatici, Giovanni Perini, Francesca Gualandi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1863:194646
Autor:
Simone Di Giacomo, Stefania Purgato, Sara Monticelli, Paolo Pigini, Michelle Haber, Daniela Erriquez, Roberto Bernardoni, Giorgio Milazzo, Murray D. Norris, Roberto Ciaccio, Giovanni Perini, Francesca Ferrucci
Publikováno v:
Biochimica et biophysica acta. Gene regulatory mechanisms. 1861(3)
Childhood neuroblastoma, a disease of the sympathetic nervous system, is the most common solid tumour of infancy, remarkably refractory to therapeutic treatments. One of the most powerful independent prognostic indicators for this disease is the ampl