Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Paolo Michieli"'
Autor:
Philippe Aftimos, Christian Rolfo, Sylvie Rottey, Philippe Barthélémy, Christophe Borg, Keunchil Park, Do-Youn Oh, Sang-We Kim, Natalie De Jonge, Valérie Hanssens, Karen Zwanenpoel, Carla Molthoff, Daniëlle Vugts, Torsten Dreier, Peter Verheesen, Guus A.M.S. van Dongen, Julie Jacobs, Luc Van Rompaey, Anna Hultberg, Paolo Michieli, Patrick Pauwels, Samson Fung, Alain Thibault, Hans de Haard, Nicolas Leupin, Ahmad Awada
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 665 (2021)
Dysregulation of MET signaling has been implicated in tumorigenesis and metastasis. ARGX-111 combines complete blockade of this pathway with enhanced tumor cell killing and was investigated in 24 patients with MET-positive advanced cancers in a phase
Externí odkaz:
https://doaj.org/article/f221f0cc086e421e96736936b19db3e0
Autor:
Marco Cassano, Stefano Biressi, Amanda Finan, Laura Benedetti, Claudia Omes, Renata Boratto, Frank Martin, Marcello Allegretti, Vania Broccoli, Gabriella Cusella De Angelis, Paolo M Comoglio, Cristina Basilico, Yvan Torrente, Paolo Michieli, Giulio Cossu, Maurilio Sampaolesi
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0220357 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0003223.].
Externí odkaz:
https://doaj.org/article/9ad05654ff534702a6662505eabe670c
Autor:
Sandra Van Schaeybroeck, Murugan Kalimutho, Philip D. Dunne, Robbie Carson, Wendy Allen, Puthen V. Jithesh, Keara L. Redmond, Takehiko Sasazuki, Senji Shirasawa, Jaine Blayney, Paolo Michieli, Cathy Fenning, Heinz-Josef Lenz, Mark Lawler, Daniel B. Longley, Patrick G. Johnston
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1940-1955 (2014)
There are currently no approved targeted therapies for advanced KRAS mutant (KRASMT) colorectal cancer (CRC). Using a unique systems biology approach, we identified JAK1/2-dependent activation of STAT3 as the key mediator of resistance to MEK inhibit
Externí odkaz:
https://doaj.org/article/8b7ccf4a717d4fdbb764fd8db5a9022b
Autor:
Marco Cassano, Stefano Biressi, Amanda Finan, Laura Benedetti, Claudia Omes, Renata Boratto, Frank Martin, Marcello Allegretti, Vania Broccoli, Gabriella Cusella De Angelis, Paolo M Comoglio, Cristina Basilico, Yvan Torrente, Paolo Michieli, Giulio Cossu, Maurilio Sampaolesi
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3223 (2008)
BACKGROUND:Hepatocyte Growth Factor (HGF) is a pleiotropic cytokine of mesenchymal origin that mediates a characteristic array of biological activities including cell proliferation, survival, motility and morphogenesis. Its high affinity receptor, th
Externí odkaz:
https://doaj.org/article/47759069091d4712b31f0bf183a12088
Autor:
Paolo Michieli, Guido Serini, Donatella Valdembri, Alberto Bardelli, Sabrina Arena, Cristina Chiriaco, Elisa Vigna, Selma Pennacchietti, Cristina Basilico
PDF File - 183K, Analysis of c-MET gene copy number and MET protein expression in a panel of human tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633279f3320c64d684099263b675f6f5
https://doi.org/10.1158/1078-0432.22448006
https://doi.org/10.1158/1078-0432.22448006
Autor:
Paolo Michieli, Guido Serini, Donatella Valdembri, Alberto Bardelli, Sabrina Arena, Cristina Chiriaco, Elisa Vigna, Selma Pennacchietti, Cristina Basilico
PDF File - 269K, Tivantinib does not inhibit HGF-dependent or -independent MET auto-phosphorylation in U87-MG glioblastoma cells and NCI-H441 lung carcinoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e45c7d475f53d3499da6bbafa986f04
https://doi.org/10.1158/1078-0432.22448003
https://doi.org/10.1158/1078-0432.22448003
Autor:
Paolo Michieli, Guido Serini, Donatella Valdembri, Alberto Bardelli, Sabrina Arena, Cristina Chiriaco, Elisa Vigna, Selma Pennacchietti, Cristina Basilico
PDF File - 61K, Drugs used in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f117f8c56959fce4ac97f0ef761f28
https://doi.org/10.1158/1078-0432.22447997.v1
https://doi.org/10.1158/1078-0432.22447997.v1
Autor:
Paolo Michieli, Guido Serini, Donatella Valdembri, Alberto Bardelli, Sabrina Arena, Cristina Chiriaco, Elisa Vigna, Selma Pennacchietti, Cristina Basilico
PDF File - 149K, MET exon 16 knock-out cells express a kinase-inactive MET protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0ccdddf477b7a16c3bb18e55663869
https://doi.org/10.1158/1078-0432.22448000
https://doi.org/10.1158/1078-0432.22448000
Autor:
Paolo Michieli, Guido Serini, Donatella Valdembri, Alberto Bardelli, Sabrina Arena, Cristina Chiriaco, Elisa Vigna, Selma Pennacchietti, Cristina Basilico
Purpose: MET, the high-affinity receptor for hepatocyte growth factor, is frequently deregulated in human cancer. Tivantinib (ARQ197; Arqule), a staurosporine derivative that binds to the dephosphorylated MET kinase in vitro, is being tested clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d7edfcc7c020e8a3dda63b68b6e662
https://doi.org/10.1158/1078-0432.c.6521273.v1
https://doi.org/10.1158/1078-0432.c.6521273.v1
Autor:
Paolo Michieli, Livio Trusolino, Paolo M. Comoglio, Timothy Perera, Jeno Gyuris, May Han, William M. Rideout, Andrea Bertotti, Manuela Cazzanti, Selma Pennacchietti
Supplementary Fig. 1. HGF protects MET-addicted tumor cells against MET TKI-induced growth inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af88691e52ae1e695fa93e650e6cecfe
https://doi.org/10.1158/0008-5472.22404062
https://doi.org/10.1158/0008-5472.22404062