Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Paolo Meda"'
Autor:
Karthik Sathiyanadan, Florian Alonso, Sonia Domingos-Pereira, Tania Santoro, Lauriane Hamard, Valérie Cesson, Paolo Meda, Denise Nardelli-Haefliger, Jacques-Antoine Haefliger
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2930 (2022)
Connexin37 (Cx37) and Cx40 form intercellular channels between endothelial cells (EC), which contribute to the regulation of the functions of vessels. We previously documented the participation of both Cx in developmental angiogenesis and have furthe
Externí odkaz:
https://doaj.org/article/b8d96369621c4549a8e82d2cfd11de01
Autor:
Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Noelia García Rodríguez, Irene de Gracia Herrera Gómez, Esther Fuente-Martin, Livia López-Noriega, José Manuel Mellado-Gil, Silvana-Yanina Romero-Zerbo, Mathurin Baquié, Christian Claude Lachaud, Katja Stifter, German Perdomo, Marco Bugliani, Vincenzo De Tata, Domenico Bosco, Geraldine Parnaud, David Pozo, Abdelkrim Hmadcha, Javier P. Florido, Miguel G. Toscano, Peter de Haan, Kristina Schoonjans, Luis Sánchez Palazón, Piero Marchetti, Reinhold Schirmbeck, Alejandro Martín-Montalvo, Paolo Meda, Bernat Soria, Francisco-Javier Bermúdez-Silva, Luc St-Onge, Benoit R. Gauthier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated
Externí odkaz:
https://doaj.org/article/fbb9d971aff1451c95b83f3e8763290c
Autor:
Antonio J. Jimenez-Caliani, Rudolf Pillich, Wendy Yang, Giuseppe R. Diaferia, Paolo Meda, Laura Crisa, Vincenzo Cirulli
Publikováno v:
Cell Reports, Vol 20, Iss 6, Pp 1295-1306 (2017)
The development and function of epithelia depend on the establishment and maintenance of cell-cell adhesion and intercellular junctions, which operate as mechanosensor hubs for the transduction of biochemical signals regulating cell proliferation, di
Externí odkaz:
https://doaj.org/article/eab1946e9b9044a7b3ed2efe4569912f
Autor:
Loïc Le Gal, Maxime Pellegrin, Tania Santoro, Lucia Mazzolai, Armin Kurtz, Paolo Meda, Charlotte Wagner, Jacques‐Antoine Haefliger
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 8 (2019)
Background Gap junction channels made of Connexin37 (Cx37) are expressed by aortic endothelial and smooth muscle cells of hypertensive mice, as well as by the renin‐secreting cells of kidneys. Methods and Results To decipher whether Cx37 has any ro
Externí odkaz:
https://doaj.org/article/a237c2aead0840e28fdf9fe8a7569937
Autor:
Paolo Meda, Jacques-Antoine Haefliger
Publikováno v:
Swiss Medical Weekly, Vol 146, Iss 4950 (2016)
Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the
Externí odkaz:
https://doaj.org/article/268a5b41bf2e42f1b75b76090164ee2d
Autor:
Smaragda Lamprianou, Conny Gysemans, Joanna Bou Saab, Helena Pontes, Chantal Mathieu, Paolo Meda
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168839 (2016)
Previous work has revealed that Cx36, the sole connexin expressed in the insulin-producing beta cells, enhances the secretion of insulin, and promotes the resistance of beta cells against pro-inflammatory cytokines. In parallel, the anti-diabetic sul
Externí odkaz:
https://doaj.org/article/40a570168bd34dbc9aada20240e94a56
Autor:
Valentina Cigliola, Celine Populaire, Ciro L Pierri, Samuel Deutsch, Jacques-Antoine Haefliger, João Fadista, Valeriya Lyssenko, Leif Groop, Rico Rueedi, Fabrizio Thorel, Pedro Luis Herrera, Paolo Meda
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150880 (2016)
Signalling through gap junctions contributes to control insulin secretion and, thus, blood glucose levels. Gap junctions of the insulin-producing β-cells are made of connexin 36 (Cx36), which is encoded by the GJD2 gene. Cx36-null mice feature alter
Externí odkaz:
https://doaj.org/article/235ee19e0b3f4349a307a413ec2ed52d
Autor:
Rami Sommerstein, Lukas Flatz, Melissa M Remy, Pauline Malinge, Giovanni Magistrelli, Nicolas Fischer, Mehmet Sahin, Andreas Bergthaler, Sebastien Igonet, Jan Ter Meulen, Dorothée Rigo, Paolo Meda, Nadia Rabah, Bruno Coutard, Thomas A Bowden, Paul-Henri Lambert, Claire-Anne Siegrist, Daniel D Pinschewer
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005276 (2015)
Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans. As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb) responses represent a unifying characteristic of both natural infection a
Externí odkaz:
https://doaj.org/article/88adfa2938774026b7ab7e3f585a6933
Autor:
Jacques-Antoine Haefliger, David Martin, Dimitri Favre, Yannick Petremand, Lucia Mazzolai, Amar Abderrahmani, Paolo Meda, Gérard Waeber, Florent Allagnat
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55198 (2013)
Connexin36 (Cx36), a trans-membrane protein that forms gap junctions between insulin-secreting beta-cells in the Langerhans islets, contributes to the proper control of insulin secretion and beta-cell survival. Hypercholesterolemia and pro-atherogeni
Externí odkaz:
https://doaj.org/article/f8babb6d3387419195d10a1ed47ad01c
Autor:
Paolo Meda
Publikováno v:
Scientifica, Vol 2013 (2013)
The islets of Langerhans collectively form the endocrine pancreas, the organ that is soley responsible for insulin secretion in mammals, and which plays a prominent role in the control of circulating glucose and metabolism. Normal function of these i
Externí odkaz:
https://doaj.org/article/cb64c3cfe48e4d27894220745b9483a1