Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paolo Mangiagalli"'
Publikováno v:
Tribology letters 70(2), 35 (2022). doi:10.1007/s11249-022-01574-7
We study the leakage of fluids (liquids or gases) in syringes with glass barrel, steel plunger and rubber O-ring stopper. The leakrate depends on the interfacial surface roughness and on the viscoelastic properties of the rubber. Random surface rough
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a548f6fbca2ebad8d6d6bb6c851b59
https://doi.org/10.21203/rs.3.rs-979477/v1
https://doi.org/10.21203/rs.3.rs-979477/v1
Publikováno v:
234702-1-234702-25
The journal of chemical physics 148(23), 234702 (2018). doi:10.1063/1.5025605
Journal of Chemical Physics
The journal of chemical physics 148(23), 234702 (2018). doi:10.1063/1.5025605
Journal of Chemical Physics
We study the adhesion between differently processed glass and filled bromobutyl rubber in dry conditions, in water, and in silicone oil. The boundary line between contact and non-contact in adhesion experiments can be considered as a mode I crack, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e844e2d5b6eb482f8f4cdce09eed04cf
http://hdl.handle.net/11250/2585380
http://hdl.handle.net/11250/2585380
Publikováno v:
AAPS PharmSciTech. 15:1398-1409
The occurrence of glass delamination is a serious concern for parenteral drug products. Over the past several years, there has been a series of product recalls involving glass delamination in parenteral drugs stored in vials which has led to heighten
Publikováno v:
Protein Science. 21:1113-1125
Gaining more insight into the mechanisms governing the behavior of proteins at solid/liquid interfaces is particularly relevant in the interaction of high-value biologics with storage and delivery device surfaces, where adsorption-induced conformatio
Autor:
Paolo Mangiagalli, Thomas Spitznagel, Michael Rosario Defelippis, Andrew Weiskopf, Bernardo Perez-Ramirez, Hanns-Christian Mahler, Douglas P. Nesta, Atanas Koulov, Patrick Garidel, Robert Simler, Klaus Wuchner, Irene Cecchini, Patricia W. Cash, Vincent Corvari, Linda O. Narhi, Mara Rossi, Roland Schmidt, Shawn Cao, Tony Lubiniecki, Alla Polozova, Andrea Herre, Satish K. Singh, Nataliya Afonina
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 43(6)
Measurement and characterization of subvisible particles (including proteinaceous and non-proteinaceous particulate matter) is an important aspect of the pharmaceutical development process for biotherapeutics. Health authorities have increased expect
Autor:
Irene Cecchini, Paolo Mangiagalli, Robert Simler, Hanns-Christian Mahler, Douglas P. Nesta, Patrick Garidel, Dean C. Ripple, Atanas Koulov, Mara Rossi, Bernardo Perez-Ramirez, Satish K. Singh, Thomas Spitznagel, Alla Polozova, Andrew Weiskopf, Nataliya Afonina, Linda O. Narhi, Andrea Herre, Roland Schmidt, Tony Lubiniecki, Vincent Corvari, Michael Rosario Defelippis, Klaus Wuchner
Publikováno v:
Journal of pharmaceutical sciences. 104(6)
Measurement and characterization of subvisible particles (defined here as those ranging in size from 2 to 100 μm), including proteinaceous and nonproteinaceous particles, is an important part of every stage of protein therapeutic development. The to
Autor:
Hervé Soukiassian, Sébastien Janvier, Sébastien Jouffray, Paolo Mangiagalli, Flora Felsovalyi
Publikováno v:
Journal of pharmaceutical sciences. 101(12)
Recent increased regulatory scrutiny concerning subvisible particulates (SbVPs) in parenteral formulations of biologics has led to the publication of numerous articles about the sources, characteristics, implications, and approaches to monitoring and
Autor:
Laurence Boulangé, Laurent Nault, Thomas Perret, Marianne Weidenhaupt, Franz Brukert, Paolo Mangiagalli, Christophe Bureau, Thomas Ballet
Publikováno v:
Biochemistry
Biochemistry, American Chemical Society, 2012, 51 (11), pp.2172-2180. ⟨10.1021/bi201457u⟩
Biochemistry, American Chemical Society, 2012, 51 (11), pp.2172-2180. ⟨10.1021/bi201457u⟩
International audience; We have developed a multiwell-based protein aggregation assay to study the kinetics of insulin adsorption and aggregation on hydrophobic surfaces and to investigate the molecular mechanisms involved. Protein-surface interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66b964a948eaf6bf25b0bc7938879f6
https://hal.archives-ouvertes.fr/hal-01067505
https://hal.archives-ouvertes.fr/hal-01067505
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 27(19)
A central paradigm that underpins our understanding of the interaction of proteins with solid surfaces is that protein adsorption leads to changes in secondary structure. The bound proteins tend to denature, and these non-native, adsorbed structures
Publikováno v:
Biophysical Journal. 102:43a
Maintaining the stability of a biologically-active therapeutic agent throughout its lifecycle is a critical parameter in successful pharmaceutical formulation. Interfacial effects such as surface adsorption, which can occur during drug storage and de