Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Paolo Lupattelli"'
Autor:
Ilaria Caivano, Alessandro Santarsiere, Mario Amati, Paolo Convertini, Maria Funicello, Paolo Lupattelli, Lucia Chiummiento, Anna Santarsiero
Publikováno v:
Organics, Vol 5, Iss 3, Pp 237-251 (2024)
Permethylated anigopreissin A (PAA), a fully protected form of the natural anigopreissin A, was found in our previous study to be active against several cancer cells, up to IC50 0.24 μM for HepG2 cells. Herein, a total of thirteen PAA analogues with
Externí odkaz:
https://doaj.org/article/a5b796d6e5634fc7aeb50f8606596f2c
Autor:
Maria Francesca Armentano, Paolo Lupattelli, Faustino Bisaccia, Rosarita D'Orsi, Rocchina Miglionico, Ilaria Nigro, Alessandro Santarsiere, Federico Berti, Maria Funicello, Lucia Chiummiento
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101165- (2023)
The Virus HIV-1 infection still represents a serious disease even if actually it is transformed in chronic pathology. Considering the crucial role of the enzyme Protease in life cycle of HIV many efforts have been made in the research of new organic
Externí odkaz:
https://doaj.org/article/cd30dfc7f8ac4c1e85f277fe1e057030
Autor:
Davide Gentile, Lucia Chiummiento, Alessandro Santarsiere, Maria Funicello, Paolo Lupattelli, Antonio Rescifina, Assunta Venuti, Anna Piperno, Maria Teresa Sciortino, Rosamaria Pennisi
Publikováno v:
Viruses, Vol 16, Iss 3, p 338 (2024)
The continuous emergence of SARS-CoV-2 variants caused the persistence of the COVID-19 epidemic and challenged the effectiveness of the existing vaccines. The viral proteases are the most attractive targets for developing antiviral drugs. In this sce
Externí odkaz:
https://doaj.org/article/33477011c2c14ff4a9b9644772bd60c2
Autor:
Carla Caddeo, Rocchina Miglionico, Roberta Rinaldi, Ilaria Nigro, Daniela Lamorte, Lucia Chiummiento, Paolo Lupattelli, Maria Funicello, Rosarita D’Orsi, Donatella Valenti, Valentina Santoro, Anna Maria Fadda, Faustino Bisaccia, Antonio Vassallo, Maria Francesca Armentano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4552 (2023)
Liver cancer is one of the most common causes of cancer death worldwide. In recent years, substantial progress has been made in the development of systemic therapies, but there is still the need for new drugs and technologies that can increase the su
Externí odkaz:
https://doaj.org/article/fb00bbba598245c5afd1942788ab4948
Autor:
Roberta Rinaldi, Rocchina Miglionico, Ilaria Nigro, Rosarita D’Orsi, Lucia Chiummiento, Maria Funicello, Paolo Lupattelli, Ilaria Laurenzana, Alessandro Sgambato, Magnus Monné, Faustino Bisaccia, Maria Francesca Armentano
Publikováno v:
Cells, Vol 10, Iss 11, p 3052 (2021)
Background: Several pre-clinical and clinical reports suggest that HIV-1 protease inhibitors, in addition to the antiretroviral properties, possess pleiotropic pharmacological effects including anticancer action. Therefore, we investigated the pro-ap
Externí odkaz:
https://doaj.org/article/4f869766409b445eb03c8b269d245fe7
Autor:
Rosarita D’Orsi, Maria Funicello, Teresa Laurita, Paolo Lupattelli, Federico Berti, Lucia Chiummiento
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1584 (2021)
Here, we report the synthesis, enzyme inhibition and structure–activity relationship studies of a new potent class of HIV-1 protease inhibitors, which contain a pseudo-symmetric hydroxyethylamine core and heteroarylcarboxyamide moieties. The simple
Externí odkaz:
https://doaj.org/article/9cb7dd769a6d4caca673db4e89ccd6f3
Autor:
Elia Roma, Elena Mattoni, Paolo Lupattelli, Seyed Sepehr Moeini, Tecla Gasperi, Roberta Bernini, Sandra Incerpi, Daniela Tofani
Publikováno v:
Molecules, Vol 25, Iss 14, p 3135 (2020)
New dihydroxytyrosyl esters 2a, 2c–2j of dicarboxylic acids were synthesized from methyl orthoformate protected hydroxytyrosol 3 and diacyl chlorides. New compounds were characterized (HRMS, FT-IR, 1H- and 13C-NMR), and tested for antioxidant activ
Externí odkaz:
https://doaj.org/article/7b9f5cb2c2804d48ac9b7175b36d1975
Publikováno v:
Molecules, Vol 25, Iss 10, p 2327 (2020)
This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals. In particular, new intramolecular and intermolecular C
Externí odkaz:
https://doaj.org/article/cda46c445efc4f7db8b1e7c3a986ab5f
Autor:
Seyed Sepehr Moeini, Chiara Battocchio, Stefano Casciardi, Igor Luisetto, Paolo Lupattelli, Daniela Tofani, Simonetta Tuti
Publikováno v:
Catalysts, Vol 9, Iss 10, p 847 (2019)
In the present study, the catalytic activity of palladium oxide (PdOx) supported on ceria nanorods (CeO2-NR) for aerobic selective oxidation of benzyl alcohol (BnOH) to benzaldehyde (PhCHO) was evaluated. The CeO2-NR was synthesized hydrothermally an
Externí odkaz:
https://doaj.org/article/58a451c695414f67860732cbc939daad
Publikováno v:
Pharmaceuticals, Vol 5, Iss 3, Pp 297-316 (2012)
This minireview provides a brief outline of the peculiar aspects of the preparation of peptidomimetic and pseudopeptidic structures containing heterocycles. In particular novel tricyclic structures are investigated as potential drugs.
Externí odkaz:
https://doaj.org/article/64f22e83693344319ef6f0596ee1bc7b