Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Paolo L Manfredi"'
Autor:
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Andrea Mattarei, Stefano Comai, Franco Folli, Marco Pappagallo, Clotilde Guidetti, Charles E. Inturrisi, Paolo L. Manfredi
Publikováno v:
Drugs in R&D, Vol 24, Iss 2, Pp 341-352 (2024)
Abstract Background and Objectives Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is a low potency N-methyl-D-aspartate (NMDA) receptor channel blocker that showed a rapid and sustained adjunctive antidepressant effec
Externí odkaz:
https://doaj.org/article/54082aea68a3451ba1202c9e94b535ab
Autor:
Martina Colognesi, Atea Shkodra, Daniela Gabbia, Hibiki Kawamata, Paolo L. Manfredi, Giovanni Manfredi, Sara De Martin
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionThe pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease caused by the demise of motor neurons has been linked to excitotoxicity caused by excessive calcium influx via N-methyl-D-aspartate receptors (NMDA
Externí odkaz:
https://doaj.org/article/a9c08acc41ac419d863b77ac7c3071c8
Autor:
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Franco Folli, Marco Pappagallo, Cedric O’Gorman, Clotilde Guidetti, Andrea Mattarei, Charles E. Inturrisi, Paolo L. Manfredi
Publikováno v:
Drugs in R&D, Vol 24, Iss 1, Pp 51-68 (2023)
Abstract Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone. Esmethadone is a low potency N-methyl-D-aspartate (NMDA) receptor channel blo
Externí odkaz:
https://doaj.org/article/9a07ec79820f4842b2bf83183c3444df
Autor:
Megan J. Shram, Jack E. Henningfield, Glen Apseloff, Charles W. Gorodetzky, Sara De Martin, Frank L. Vocci, Frank L. Sapienza, Thomas R. Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O’Gorman, Sergio Traversa, Charles E. Inturrisi, Paolo L. Manfredi, Marco Pappagallo
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robu
Externí odkaz:
https://doaj.org/article/b958bfa2946e4409a7e15362350d0462
Autor:
Jack Henningfield, David Gauvin, Francesco Bifari, Reginald Fant, Megan Shram, August Buchhalter, Judy Ashworth, Ryan Lanier, Marco Pappagallo, Charles Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract REL-1017 (esmethadone, d-methadone) is the opioid-inactive d-isomer of racemic d,l-methadone. REL-1017 may exert antidepressant effects via uncompetitive N-methyl-d-aspartate receptor (NMDAR) channel block. As REL-1017 is expected to exert c
Externí odkaz:
https://doaj.org/article/af8fabe8ee0d48f4ab00370a37dd858f
Autor:
Francesco Bifari, Marco Pappagallo, Michael Bleavins, Sergio Traversa, Franco Folli, Paolo L. Manfredi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
REL-1017 (esmethadone; dextromethadone; (S)-methadone) is the opioid-inactive dextro-isomer of the racemic mixture, (R, S)-methadone. REL-1017 acts as a low affinity, low potency N-methyl-D-aspartate receptor (NMDAR) channel blocker with rapid, robus
Externí odkaz:
https://doaj.org/article/c8b0beaef641458ca60f25965e8c4aa2
Autor:
Ezio Bettini, Stephen M. Stahl, Sara De Martin, Andrea Mattarei, Jacopo Sgrignani, Corrado Carignani, Selena Nola, Patrizia Locatelli, Marco Pappagallo, Charles E. Inturrisi, Francesco Bifari, Andrea Cavalli, Andrea Alimonti, Luca Pani, Maurizio Fava, Sergio Traversa, Franco Folli, Paolo L. Manfredi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 997 (2022)
Excessive Ca2+ currents via N-methyl-D-aspartate receptors (NMDARs) have been implicated in many disorders. Uncompetitive NMDAR channel blockers are an emerging class of drugs in clinical use for major depressive disorder (MDD) and other neuropsychia
Externí odkaz:
https://doaj.org/article/a9489daf59de4062bfa561e5de1336f9
Autor:
Sara De Martin, Daniela Gabbia, Franco Folli, Francesco Bifari, Paolo Fiorina, Nicola Ferri, Stephen Stahl, Charles E. Inturrisi, Marco Pappagallo, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Brain-derived neurotrophic factor (BDNF), a neurotrophin widely expressed in the central nervous system, exhibits important effects on neural plasticity. BDNF has been implicated in the mechanism of action of ketamine, a N-methyl-d-aspartic acid rece
Externí odkaz:
https://doaj.org/article/bc0cdc1dafc040f7ae823a00bba8a45f
Autor:
Ezio Bettini, Sara De Martin, Andrea Mattarei, Marco Pappagallo, Stephen M. Stahl, Francesco Bifari, Charles E. Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 882 (2022)
REL-1017 (esmethadone) is a novel N-methyl-D-aspartate receptor (NMDAR) antagonist and promising rapid antidepressant candidate. Using fluorometric imaging plate reader (FLIPR) assays, we studied the effects of quinolinic acid (QA) and gentamicin, wi
Externí odkaz:
https://doaj.org/article/790f963de6d14b359c5bec9f2fbe1fc3
Autor:
Clotilde Guidetti, Giulia Serra, Luca Pani, Marco Pappagallo, Gino Maglio, Sara De Martin, Andrea Mattarei, Franco Folli, Paolo L. Manfredi, Maurizio Fava
Publikováno v:
The Primary Care Companion For CNS Disorders. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22afb39b687d058b98202ad06b4fef9f
https://doi.org/10.4088/pcc.22m03267
https://doi.org/10.4088/pcc.22m03267