Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Paolo Guarnieri"'
Autor:
Matteo Floris, Antonino Moschella, Myriam Alcalay, Annalaura Montella, Matilde Tirelli, Laura Fontana, Maria Laura Idda, Pharmacogenomics Working Group of the Italian Society of Human Genetics (SIGU), Paolo Guarnieri, Mario Capasso, Corrado Mammì, Paola Nicoletti, Monica Miozzo
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-13 (2024)
Abstract Pharmacogenetics investigates sequence of genes that affect drug response, enabling personalized medication. This approach reduces drug-induced adverse reactions and improves clinical effectiveness, making it a crucial consideration for pers
Externí odkaz:
https://doaj.org/article/ee98d4d6ede14313a133bbdf3fbf6f01
Autor:
Tianyi Chen, George Dalton, Seh-Hoon Oh, Raquel Maeso-Diaz, Kuo Du, Rachel A. Meyers, Cynthia Guy, Manal F. Abdelmalek, Ricardo Henao, Paolo Guarnieri, Steven S. Pullen, Simon Gregory, Joseph Locker, J. Mark Brown, Anna Mae Diehl
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 4, Pp 949-970 (2023)
Background & Aims: Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis, strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state that disrupts energy balance and promotes progressive liver degeneration
Externí odkaz:
https://doaj.org/article/9a1fec7762f04ba181df024b17ce1685
Autor:
Fabian Heinemann, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, Anna Mae Diehl, Manal Abdelmalek, Martin C. Lenter, Steven S. Pullen, Paolo Guarnieri, Birgit Stierstorfer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form non-alcoholic steatohepatitis (NASH), and ultimately to cirrhosis or liver cancer.
Externí odkaz:
https://doaj.org/article/d03e21bdb66a47cf83dafba82490bd38
Autor:
Paola Nicoletti, Mukesh Bansal, Celine Lefebvre, Paolo Guarnieri, Yufeng Shen, Itsik Pe'er, Andrea Califano, Aris Floratos
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131038 (2015)
Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) represent rare but serious adverse drug reactions (ADRs). Both are characterized by distinctive blistering lesions and significant mortality rates. While there is evidence for strong
Externí odkaz:
https://doaj.org/article/590cd58bb145420c8077ae032093e256
Autor:
Liang Lei, Adam M Sonabend, Paolo Guarnieri, Craig Soderquist, Thomas Ludwig, Steven Rosenfeld, Jeffrey N Bruce, Peter Canoll
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20041 (2011)
Tumor heterogeneity is a major obstacle for finding effective treatment of Glioblastoma (GBM). Based on global expression analysis, GBM can be classified into distinct subtypes: Proneural, Neural, Classical and Mesenchymal. The signatures of these di
Externí odkaz:
https://doaj.org/article/60506fdecb2b47eba00d79270293e9b2
Autor:
Peter Canoll, Andrea Califano, Jeffrey N. Bruce, Peter A. Sims, Steven Rosenfeld, Thomas Ludwig, Reena Shakya, Rachel Bruce, Samuel Bruce, Julia Sisti, Benjamin Kennedy, Jonathan Yun, Richard Leung, Craig Soderquist, Benjamin Amendolara, Liang Lei, Paolo Guarnieri, Mukesh Bansal, Adam M. Sonabend
PDF - 1816K, Supplementary Figure 1: CGH probe for Cre-mediated Pten deletion provides a surrogate of tumor DNA content for mouse tumors. Supplementary Figure 2: The genomic architecture of mouse tumor gene deletions suggests independent selection pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afcb12591fefa3c895f7af0cb97814f
https://doi.org/10.1158/0008-5472.22401824.v1
https://doi.org/10.1158/0008-5472.22401824.v1
Autor:
Peter Canoll, Andrea Califano, Jeffrey N. Bruce, Peter A. Sims, Steven Rosenfeld, Thomas Ludwig, Reena Shakya, Rachel Bruce, Samuel Bruce, Julia Sisti, Benjamin Kennedy, Jonathan Yun, Richard Leung, Craig Soderquist, Benjamin Amendolara, Liang Lei, Paolo Guarnieri, Mukesh Bansal, Adam M. Sonabend
Proneural glioblastoma is defined by an expression pattern resembling that of oligodendrocyte progenitor cells and carries a distinctive set of genetic alterations. Whether there is a functional relationship between the proneural phenotype and the as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f411d64d81157b50de931add81a7ed
https://doi.org/10.1158/0008-5472.c.6505928
https://doi.org/10.1158/0008-5472.c.6505928
Autor:
Peter Canoll, Andrea Califano, Jeffrey N. Bruce, Peter A. Sims, Steven Rosenfeld, Thomas Ludwig, Reena Shakya, Rachel Bruce, Samuel Bruce, Julia Sisti, Benjamin Kennedy, Jonathan Yun, Richard Leung, Craig Soderquist, Benjamin Amendolara, Liang Lei, Paolo Guarnieri, Mukesh Bansal, Adam M. Sonabend
XLSX - 1231K, Supplementary Table 1: List of genes deleted in 75 to 100% of the end-stage *PTEN tumors Supplementary Table 2: List of genes showing copy number gains in *PTEN end-stage and *PTEN/p53 mouse tumors. Supplementary Table 3: Genes that wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c2864195913075d68413f0508106cf
https://doi.org/10.1158/0008-5472.22401821.v1
https://doi.org/10.1158/0008-5472.22401821.v1
Autor:
Peter Canoll, Andrea Califano, Jeffrey N. Bruce, Peter A. Sims, Steven Rosenfeld, Thomas Ludwig, Reena Shakya, Rachel Bruce, Samuel Bruce, Julia Sisti, Benjamin Kennedy, Jonathan Yun, Richard Leung, Craig Soderquist, Benjamin Amendolara, Liang Lei, Paolo Guarnieri, Mukesh Bansal, Adam M. Sonabend
PDF - 106K, Contains the legends for Supplementary Figures 1-6 and Supplementary Tables 1-7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d814de3963486c40a68ae7f3c8a11fab
https://doi.org/10.1158/0008-5472.22401827.v1
https://doi.org/10.1158/0008-5472.22401827.v1
Autor:
Amin Abedini, Ziyuan Ma, Julia Frederick, Poonam Dhillon, Michael S. Balzer, Rojesh Shrestha, Hongbo Liu, Steven Vitale, Kishor Devalaraja-Narashimha, Paola Grandi, Tanmoy Bhattacharyya, Erding Hu, Steven S. Pullen, Carine M Boustany-Kari, Paolo Guarnieri, Anil Karihaloo, Hanying Yan, Kyle Coleman, Matthew Palmer, Lea Sarov-Blat, Lori Morton, Christopher A. Hunter, Mingyao Li, Katalin Susztak
Kidneys have one of the most complex three-dimensional cellular organizations in the body, but the spatial molecular principles of kidney health and disease are poorly understood. Here we generate high-quality single cell (sc), single nuclear (sn), s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ef1d19933dc237011cb55146afd17db
https://doi.org/10.1101/2022.10.24.513598
https://doi.org/10.1101/2022.10.24.513598