Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Paolo Falvo"'
Autor:
Francesca Reggiani, Giovanna Talarico, Giulia Gobbi, Elisabetta Sauta, Federica Torricelli, Veronica Manicardi, Eleonora Zanetti, Stefania Orecchioni, Paolo Falvo, Simonetta Piana, Filippo Lococo, Massimiliano Paci, Francesco Bertolini, Alessia Ciarrocchi, Valentina Sancisi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Non-small-cell lung carcinoma (NSCLC) is the most common lung cancer and one of the pioneer tumors in which immunotherapy has radically changed patients’ outcomes. However, several issues are emerging and their implementation is required t
Externí odkaz:
https://doaj.org/article/c704ebd7f1334bbaabe7ff0c4620fb62
Autor:
Rani Pallavi, Elena Gatti, Tiphanie Durfort, Massimo Stendardo, Roberto Ravasio, Tommaso Leonardi, Paolo Falvo, Bruno Achutti Duso, Simona Punzi, Aobuli Xieraili, Andrea Polazzi, Doriana Verrelli, Deborah Trastulli, Simona Ronzoni, Simone Frascolla, Giulia Perticari, Mohamed Elgendy, Mario Varasi, Emanuela Colombo, Marco Giorgio, Luisa Lanfrancone, Saverio Minucci, Luca Mazzarella, Pier Giuseppe Pelicci
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Caloric Restriction (CR) has established anti-cancer effects, but its clinical relevance and molecular mechanism remain largely undefined. Here, we investigate CR’s impact on several mouse models of Acute Myeloid Leukemias, including Acute
Externí odkaz:
https://doaj.org/article/8f7683b064194aa894f4ffe6b6a13e8b
Autor:
Laura Carpen, Paolo Falvo, Stefania Orecchioni, Giulia Mitola, Roman Hillje, Saveria Mazzara, Patrizia Mancuso, Stefano Pileri, Alessandro Raveane, Francesco Bertolini
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract Breast cancer (BC) constitutes a major health problem worldwide, making it the most common malignancy in women. Current treatment options for BC depend primarily on histological type, molecular markers, clinical aggressiveness and stage of d
Externí odkaz:
https://doaj.org/article/6e526aea2e4d491f9fe6d4a686e24985
Autor:
Sana Belkahla, Joaquin Marco Brualla, Alexis Fayd’herbe de Maudave, Paolo Falvo, Nerea Allende-Vega, Michael Constantinides, Abrar Ul Haq Khan, Lois Coenon, Catherine Alexia, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Wissem Mnif, Javier Hernandez, Alberto Anel, Martin Villalba
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism to adapt to their high growth. This change can stress cells and facilitate recognition by immune cells such as cytotoxic lymph
Externí odkaz:
https://doaj.org/article/0a6c7e5f1a1d4f84b4d02628999b7b05
Autor:
Nerea Allende-Vega, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd’herbe de Maudave, Lois Coenon, Delphine Gitenay, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Isabel Marzo, Alberto Anel, Martin Villalba
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of sol
Externí odkaz:
https://doaj.org/article/80ab263158524947a4f42174b3b1b555
Autor:
Stefania Orecchioni, Paolo Falvo, Giovanna Talarico, Giulia Mitola, Giulia Bravetti, Patrizia Mancuso, Paola Nicoli, Francesco Bertolini
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 7, p 2535 (2023)
We have previously shown in triple-negative breast cancer (TNBC) models that a triple therapy (TT) including intermittent cyclophosphamide (C), vinorelbine (V), and anti-PD-1 activates antigen-presenting cells (APC) and generates stem like-T cells ab
Externí odkaz:
https://doaj.org/article/560e31b84fb64af3b64940093455bad2
Publikováno v:
Life, Vol 11, Iss 11, p 1131 (2021)
Disease relapse caused by drug resistance still represents a major clinical hurdle in cancer treatments. Tumor cells may take advantage of different intracellular and genetic systems attenuating the drug effects. Resistant cells or minimal residual d
Externí odkaz:
https://doaj.org/article/d75c0a279a704ce8824a27bc2c754cda
Autor:
Sara Trabanelli, Mathieu F. Chevalier, Amaia Martinez-Usatorre, Alejandra Gomez-Cadena, Bérengère Salomé, Mariangela Lecciso, Valentina Salvestrini, Grégory Verdeil, Julien Racle, Cristina Papayannidis, Hideaki Morita, Irene Pizzitola, Camille Grandclément, Perrine Bohner, Elena Bruni, Mukul Girotra, Rani Pallavi, Paolo Falvo, Elisabeth Oppliger Leibundgut, Gabriela M. Baerlocher, Carmelo Carlo-Stella, Daniela Taurino, Armando Santoro, Orietta Spinelli, Alessandro Rambaldi, Emanuela Giarin, Giuseppe Basso, Cristina Tresoldi, Fabio Ciceri, David Gfeller, Cezmi A. Akdis, Luca Mazzarella, Saverio Minucci, Pier Giuseppe Pelicci, Emanuela Marcenaro, Andrew N. J. McKenzie, Dominique Vanhecke, George Coukos, Domenico Mavilio, Antonio Curti, Laurent Derré, Camilla Jandus
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce m
Externí odkaz:
https://doaj.org/article/acd6edf30f5b42e78199d6bb93f923c9
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1359 (2021)
The incidence and severity of obesity are rising in most of the world. In addition to metabolic disorders, obesity is associated with an increase in the incidence and severity of a variety of types of cancer, including breast cancer (BC). The bidirec
Externí odkaz:
https://doaj.org/article/12c06d5ca22c4c318d8ebc05ce29aa4c
Autor:
Valerio Vitelli, Paolo Falvo, Solomon G. Nergadze, Marco Santagostino, Lela Khoriauli, Paola Pellanda, Giulia Bertino, Antonio Occhini, Marco Benazzo, Patrizia Morbini, Marco Paulli, Camillo Porta, Elena Giulotto
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 1, p 274 (2018)
Telomeres are transcribed into noncoding telomeric repeat-containing RNAs (TERRA), which are essential for telomere maintenance. Deregulation of TERRA transcription impairs telomere metabolism and a role in tumorigenesis has been proposed. Head and n
Externí odkaz:
https://doaj.org/article/8b2cb80c8cd3468abec6c25dd78b24ba