Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Paolo Fagone"'
Autor:
Katia Mangano, Aristidis Diamantopoulos, Natalia G. Vallianou, Theodora Stratigou, Fotis Panagopoulos, Dimitris Kounatidis, Maria Dalamaga, Paolo Fagone, Ferdinando Nicoletti
Publikováno v:
Metabolism Open, Vol 24, Iss , Pp 100320- (2024)
Background: Macrophage migration inhibitory factor (MIF) is a highly conserved cytokine with pleiotropic properties, mainly pro-inflammatory. MIF seems to exert its pro-inflammatory features by binding to its transmembrane cellular receptor CD74. MIF
Externí odkaz:
https://doaj.org/article/f0e12ffd3eb3411684d25498797dd470
Publikováno v:
Cells, Vol 13, Iss 15, p 1299 (2024)
Triple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer, with a bad prognosis and lack of targeted therapeutic options. Characterized by the absence of estrogen receptors, progesterone receptors, and HER2 expression, TN
Externí odkaz:
https://doaj.org/article/8a8adf4173254f3c919ed938e3ba9f6c
Autor:
Silviya Abarova, Ralitza Alexova, Stela Dragomanova, Ayten Solak, Paolo Fagone, Katia Mangano, Maria Cristina Petralia, Ferdinando Nicoletti, Reni Kalfin, Lyubka Tancheva
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 130 (2024)
The existing literature supports the anti-inflammatory, antioxidant, and antiviral capacities of the polyphenol extracts derived from Geranium sanguineum L. These extracts exhibit potential in hindering viral replication by inhibiting enzymes like DN
Externí odkaz:
https://doaj.org/article/edd0886ad1b94db3bb28aca0125725f2
Autor:
Sagar B Kudchodkar, Paolo Fagone, Omkar U Kawalekar, Moonsup Jeong, Christine C Roberts, Hyojin Lee, Youngran Cho, Areum Gil, Yeeun Oh, Bohyun Jeon, Gee Ho Park, Young K Park, Ferdinando Nicoletti, Joel N Maslow, Kar Muthumani
Publikováno v:
Translational Medicine Communications, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract In the present study, the effect(s) of the immunomodulatory drug GLS-1027 on various cell types involved in inflammation were investigated. GLS-1027 reduced LPS-stimulated secretion of pro-inflammatory cytokines by macrophage or monocytic ce
Externí odkaz:
https://doaj.org/article/405ed5a8ca7941f389f90989ca81b381
Autor:
Paolo Fagone, Eliana Piombino, Katia Mangano, Rocco De Pasquale, Ferdinando Nicoletti, Rosario Caltabiano
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1352 (2023)
Discoid lupus erythematosus (DLE) is a chronic autoimmune disease that primarily affects the skin, causing red, scaly patches that may be disfiguring and can cause permanent scarring. This study aimed to investigate the potential clinical and therape
Externí odkaz:
https://doaj.org/article/d7691bbe83964f7b87e7e903a039d73d
Autor:
Ralitza Alexova, Simona Alexandrova, Stela Dragomanova, Reni Kalfin, Ayten Solak, Sidharth Mehan, Maria Cristina Petralia, Paolo Fagone, Katia Mangano, Ferdinando Nicoletti, Lyubka Tancheva
Publikováno v:
Molecules, Vol 28, Iss 9, p 3772 (2023)
Pomegranate (Punica granatum L.) is a rich source of polyphenols, including ellagitannins and ellagic acid. The plant is used in traditional medicine, and its purified components can provide anti-inflammatory and antioxidant activity and support of h
Externí odkaz:
https://doaj.org/article/1edfa561db38488bb8b08eeef07f3435
Autor:
Maria Cristina Petralia, Ferdinando Nicoletti, Lyubka Tancheva, Reni Kalfin, Paolo Fagone, Katia Mangano
Publikováno v:
Brain Sciences, Vol 12, Iss 10, p 1378 (2022)
Although the introduction of HAART has completely changed the natural course of HIV infection, the number of chronic forms of HIV-associated neurocognitive disorder (HAND) has risen. It is estimated that up to half of subjects undergoing HAART therap
Externí odkaz:
https://doaj.org/article/b858404c2b554ad288eb07f386fe46e3
Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 1005-1019 (2019)
Lipid metabolism requires CoA, an essential cofactor found in multiple subcellular compartments, including the peroxisomes. In the liver, CoA levels are dynamically adjusted between the fed and fasted states. Elevated CoA levels in the fasted state a
Externí odkaz:
https://doaj.org/article/1c946483db0e4891875238a29f6f476d
Autor:
Maria Cristina Petralia, Katia Mangano, Maria Catena Quattropani, Vittorio Lenzo, Ferdinando Nicoletti, Paolo Fagone
Publikováno v:
Brain Sciences, Vol 12, Iss 7, p 827 (2022)
Background. Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease which affects more than 50 million patients and represents 60–80% of all cases of dementia. Mutations in the APP gene, mostly affecting the γ-secretase s
Externí odkaz:
https://doaj.org/article/dd9b2169cc164c6db94cfec13a525a47
Autor:
Alexander M. Horspool, Theodore Kieffer, Brynnan P. Russ, Megan A. DeJong, M. Allison Wolf, Jacqueline M. Karakiozis, Brice J. Hickey, Paolo Fagone, Danyel H. Tacker, Justin R. Bevere, Ivan Martinez, Mariette Barbier, Peter L. Perrotta, F. Heath Damron
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
The SARS-CoV-2 pandemic is continuing to impact the global population, and knowledge of the immune response to COVID-19 is still developing. This study assesses the interplay of different parts of the immune system during COVID-19 disease.
Externí odkaz:
https://doaj.org/article/7291606a068442be9db403b0d8e1d2b6