Evaluation of prenatal calabash chalk geophagy on the developing brain of Wistar rats

Autor: Moses B. Ekong, Anna Andrioli, Imaobong E. Israel, Edemeka I. Ifot, Samuel E. Dickson, Ilaria Scambi, Paolo F. Fabene, Giuseppe Bertini, Marina Bentivoglio

Publikováno v: IBRO Neuroscience Reports, Vol 16, Iss , Pp 443-454 (2024)

Calabash chalk (CaC) is an aluminium silicate hydroxide compound with heavy metal constituents, making it a potential neurotoxicant. Pregnant women often consume CaC as an antiemetic, which may interfere with the normal development of the foetal brai

Externí odkaz: https://doaj.org/article/ba52102b092d4ffba35f1397497430dc

Rehabilitation and Biomarkers of Stroke Recovery: Study Protocol for a Randomized Controlled Trial

Autor: Chiara Della Libera, Paola Zamparo, Cristina Fonte, Stefano Tamburin, Maria Grazia Romanelli, Giovanni Malerba, Sofia Mariotto, Cristina Patuzzo, Nicola Smania, Alessandra Carcereri de Prati, Federico Schena, Valentina Varalta, Paolo F. Fabene, Massimo Donadelli, Mirko Filippetti, Andrea Sbarbati, Stefania Fochi, Chiara Milanese, Leonardo Chelazzi, Lidia Del Piccolo, Elena Butturini, Elena Locatelli, Macarena Gomez-Lira, Marialuisa Gandolfi, Massimo Venturelli, Valeria Donisi, Alessandro Picelli

Publikováno v: Frontiers in Neurology, Vol 11 (2021)
Frontiers in Neurology

Background: Stroke is a leading cause of disability. Nonetheless, the care pathway for stroke rehabilitation takes partially into account the needs of chronic patients. This is due in part to the lack of evidence about the mechanisms of recovery afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d89d09d09a20d3fb71a36c02b4b7a0
https://www.frontiersin.org/articles/10.3389/fneur.2020.618200/full

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

Autor: Cristina R. Reschke, Junyi Su, Lara S. Costard, R. Jeroen Pasterkamp, Vamshidhar R. Vangoor, Gary P. Brennan, Federico Del Gallo, Tobias Engel, Valentin Neubert, Jochen H. M. Prehn, Aoife Campbell, Dennis Pultz, Lea M. Harder, Janosch P. Heller, Morten T. Venø, Yan Yan, David C. Henshall, Braxton A. Norwood, Jørgen Kjems, Niamh M. C. Connolly, Gareth Morris, Jens S. Andersen, Amaya Sanz-Rodriguez, Elena Langa, Stephanie Schorge, Felix Rosenow, Ajay Pal, Beatrice Salvetti, Karen Conboy, Juha Muilu, Paolo F. Fabene, Sebastian Bauer, Eva M. Jimenez-Mateos, Stefan J. Haunsberger, Amy Richardson

Publikováno v: Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Gallo, F D, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences
Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Del Gallo, F, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences of the United States of America

Significance Temporal lobe epilepsy is commonly drug resistant and is associated with dysregulated hippocampal gene expression. MicroRNAs are short noncoding RNAs which control protein levels by binding target mRNAs via Argonaute proteins. We sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef11a947b31811a4b5bce9f9ba6f9dd
https://pure.au.dk/ws/files/224579357/15977.full.pdf

The anti-inflammatory properties of mesenchymal stem cells in epilepsy: possible treatments and future perspectives

Autor: Francesca Mengoni, Giuseppe Bertini, Federico Del Gallo, Valentina Salari, Paolo F. Fabene

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 9683, p 9683 (2020)
International Journal of Molecular Sciences

Mesenchymal stem cells (MSCs) are multipotent adult cells with self-renewing capacities. MSCs display specific properties, such as the ability to repair damaged tissues, resulting in optimal candidates for cell therapy against degenerative diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa77dc772ff4c8cc602cc9f1ce498c2
http://hdl.handle.net/11562/1033348

All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium

Autor: Eda Suku, Giuseppe Bertini, Adela Banciu, Petr Kacer, Flavia Merigo, Cristina Tognoli, Mihai Radu, Alejandro Giorgetti, Daniel Dumitru Banciu, Marzia Di Chio, Beatrice Mihaela Radu, Grygoriy Tsenov, Paolo F. Fabene, Antonio Marco Maria Osculati

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these receptors have been described in human, bovine and rat cerebral microv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf112303c4c866af829b05845e5fb87
https://doaj.org/article/02226d4ad5a34ae38427c894c235be2a