Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Paolo Comeglio"'
Autor:
Paolo Comeglio, Giulia Guarnieri, Sandra Filippi, Ilaria Cellai, Gabriele Acciai, Ian Holyer, Fredrik Zetterberg, Hakon Leffler, Barbro Kahl-Knutson, Erica Sarchielli, Annamaria Morelli, Mario Maggi, Robert J. Slack, Linda Vignozzi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionGalectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that h
Externí odkaz:
https://doaj.org/article/63192e450fe54462bda8d9eeb27e6b81
Autor:
Giulia Guarnieri, Matteo Becatti, Paolo Comeglio, Linda Vignozzi, Mario Maggi, Gabriella Barbara Vannelli, Annamaria Morelli
Publikováno v:
European Journal of Histochemistry, Vol 65, Iss s1 (2021)
Benzo[a]pyrene (BaP) is a widespread pollutant that can act as an endocrine disrupting compound (EDC) and interferes with reproductive function. The central regulatory network of the reproductive system is mediated by gonadotropin-releasing hormone (
Externí odkaz:
https://doaj.org/article/fcdfba6057994786ad5e12d0f95407f2
Autor:
Annamaria Morelli, Erica Sarchielli, Giulia Guarnieri, Elisabetta Coppi, Daniela Pantano, Paolo Comeglio, Pamela Nardiello, Anna M. Pugliese, Lara Ballerini, Rosanna Matucci, Stefano Ambrosini, Giuseppe Castronovo, Rosa Valente, Benedetta Mazzanti, Sandra Bucciantini, Mario Maggi, Fiorella Casamenti, Pasquale Gallina, Gabriella B. Vannelli
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
The degeneration of cholinergic neurons of the nucleus basalis of Meynert (NBM) in the basal forebrain (BF) is associated to the cognitive decline of Alzheimer’s disease (AD) patients. To date no resolutive therapies exist. Cell-based replacement t
Externí odkaz:
https://doaj.org/article/f59531ff79ea4a4d989e2d27d6dd62d8
Autor:
Annamaria Morelli, Paolo Comeglio, Erica Sarchielli, Ilaria Cellai, Linda Vignozzi, Gabriella B. Vannelli, Mario Maggi
Publikováno v:
International Journal of Endocrinology, Vol 2013 (2013)
Metabolic disorders are often associated with male hypogonadotropic hypogonadism, suggesting that hypothalamic defects involving GnRH neurons may impair the reproductive function. Among metabolic factors hyperglycemia has been implicated in the contr
Externí odkaz:
https://doaj.org/article/a4542e4437464212bc1a7890d6b27439
Autor:
Ilaria Cellai, Paolo Comeglio, Sandra Filippi, Serena Martinelli, Fabio Villanelli, Francesca Amore, Elena Rapizzi, Elisa Maseroli, Sarah Cipriani, Chiara Raddi, Giulia Guarnieri, Erica Sarchielli, Giovanna Danza, Annamaria Morelli, Giulia Rastrelli, Mario Maggi, Linda Vignozzi
Publikováno v:
The Journal of Sexual Medicine. 20:1-13
BackgroundSex steroids have been demonstrated as important modulators of vaginal function. The RhoA/ROCK calcium-sensitizing pathway plays a role in genital smooth muscle contractile mechanism, but its regulation has never been elucidated.AimThis stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::873061a0916b1b54a1ec1f2abf289c3d
https://doi.org/10.1093/jsxmed/qdac009
https://doi.org/10.1093/jsxmed/qdac009
Autor:
Giovanni Corona, Giulia Rastrelli, Paolo Comeglio, Federica Guaraldi, Diego Mazzatenta, Alessandra Sforza, Linda Vignozzi, Mario Maggi
Publikováno v:
Expert Review of Endocrinology & Metabolism. 17:533-545
Hyperprolactinemia has been proven to induce hypogonadism and metabolic derangements in both genders, while the consequences of prolactin (PRL) deficiency have been poorly investigated.To systematically review and analyze data from clinical studies f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9eb9d73f9c88011a6daf71ccc765d1
https://doi.org/10.1080/17446651.2022.2144829
https://doi.org/10.1080/17446651.2022.2144829
Autor:
Tommaso Mello, Andrea Galli, Mario Maggi, Paolo Comeglio, Ilaria Cellai, Benjamin J Bruno, Sandra Filippi, Elisa Maseroli, Giulia Guarnieri, K. Papangkorn, Erica Sarchielli, K. Vangara, Sarah Cipriani, Annamaria Morelli, N. Chidambaram, Giulia Rastrelli, K. Kim, Linda Vignozzi, M. V. Patel
Publikováno v:
Journal of Endocrinological Investigation
Purpose Low free testosterone (T) level in men is independently associated with presence and severity of Non-Alcoholic Steatohepatitis (NASH). The histological and molecular effects of oral testosterone prodrug LPCN 1144 treatment on hepatic fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a85cd9227ffe51882140026d84a5734
https://doi.org/10.1007/s40618-021-01522-7
https://doi.org/10.1007/s40618-021-01522-7
Autor:
Giulia Rastrelli, Ilaria Cellai, Paolo Comeglio, Erica Sarchielli, Daniele Bani, Sandra Filippi, Elena Rapizzi, Gabriella B. Vannelli, Linda Vignozzi, Mario Maggi, Giulia Guarnieri, Daniele Guasti, Annamaria Morelli
Publikováno v:
Journal of Endocrinology. 245:259-279
Lifestyle modifications, including physical exercise (PhyEx), are well-known treatments for metabolic syndrome (MetS), a cluster of metabolic and cardiovascular risk factors often associated to hypogonadism. Given the trophic role of testosterone on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2366176e70680fc545bf355b1fa53be2
https://doi.org/10.1530/joe-19-0532
https://doi.org/10.1530/joe-19-0532
Autor:
Rachele Garella, Emanuele Cassioli, Flaminia Chellini, Alessia Tani, Eleonora Rossi, Eglantina Idrizaj, Daniele Guasti, Paolo Comeglio, Francesco Palmieri, Martina Parigi, Linda Vignozzi, Maria Caterina Baccari, Valdo Ricca, Chiara Sassoli, Giovanni Castellini, Roberta Squecco
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1082
Adiponectin (ADPN), a hormone produced by adipose tissue, facilitates gastric relaxation and can be a satiety signal in the network connecting peripheral organs and the central nervous system for feeding behavior control. Here, we performed preclinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cda334cc563ee5dfdfa8f452b08b3e
https://doi.org/10.3390/ijms24021082
https://doi.org/10.3390/ijms24021082
Autor:
Giulia Guarnieri, Matteo Becatti, Roberta Squecco, Paolo Comeglio, Rachele Garella, Lara Tamburrino, Sara Marchiani, Linda Vignozzi, Gabriella Barbara Vannelli, Mario Maggi, Annamaria Morelli
Publikováno v:
Environmental Pollution. 317:120766
The neuroendocrine control of reproduction is strictly coordinated at the central level by the pulsatile release of gonadotropin-releasing hormone (GnRH) by the hypothalamic GnRH neurons. Alterations of the GnRH-network, especially during development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4640adb8f1a757e616ea68f9edb1996e
https://doi.org/10.1016/j.envpol.2022.120766
https://doi.org/10.1016/j.envpol.2022.120766