Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Paolo Cavanni"'
Autor:
Aldo Feriani, Laura Zonzini, Laura Castelletti, Selena Nola, Michele Dal Cin, Teresa Semeraro, Sylvie Gehanne, Silvia Tomelleri, Filippo Visentini, Palmina Cavallini, Susanna Cremonesi, Annalisa Pellacani, Anna Sava, Alessia Bacchi, Andrea Wong, Simone Braggio, Luca Tarsi, Mahmud Kajbaf, Paolo Cavanni, Elisabetta Perdona, Christian Heidbreder, Luciano Marchiò, Beatrice Oliosi, Fabrizio Micheli
Publikováno v:
Journal of Medicinal Chemistry. 59:8549-8576
A novel series of 1,2,4-triazolyl 5-azaspiro[2.4]heptanes with high affinity and selectivity at the dopamine (DA) D3 receptor (D3R) is described. Some of these compounds also have high selectivity over the hERG channel and were characterized with res
Autor:
Michele Dal Cin, Susanna Cremonesi, Simone Braggio, Andrea Wong, Aldo Feriani, Laura Zonzini, Andrea Bernardelli, Laura Castelletti, Federica Bianchi, Filippo Visentini, Palmina Cavallini, Teresa Semeraro, Silvia Tomelleri, Luca Tarsi, Christian Heidbreder, Paolo Cavanni, Fabrizio Micheli, Beatrice Oliosi
Publikováno v:
Bioorganicmedicinal chemistry. 24(8)
A novel series of 1,2,4-triazolyl octahydropyrrolo[2,3-b]pyrroles showing high affinity and selectivity at the DA D3 receptor is reported here. Compounds endowed with high selectivity over the hERG channel were identified and their pharmacokinetic pr
Autor:
Anna Sava, Luca Tarsi, Simone Braggio, Teresa Semeraro, Aldo Feriani, Laura Zonzini, Fabrizio Micheli, Beatrice Oliosi, Susanna Cremonesi, Elisabetta Perdona, Silvia Tomelleri, Paolo Cavanni, Christian Heidbreder
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(4)
A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.
Autor:
Ilaria Sartori, Laura Zonzini, Laurie J. Gordon, Angela Worby, Stefano Fontana, Manuela Borriello, Silvia Bison, Jeannette M. Watson, Steven Mark Bromidge, Giovanna Dal Forno, Colin Philip Leslie, Alessandra Pasquarello, Anna Sava, Luca G. Moccia, Barbara Bertani, Roberto Arban, Daniele Donati, Enrica Granci, Valeria Zucchelli, Paolo Cavanni, Massimo Gianotti, Romano Di-Fabio
Publikováno v:
Journal of Medicinal Chemistry. 53:5827-5843
Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of fused tricyclic benzoxazines which are potent 5-HT1A/B/D receptor antagonists with and wit
Autor:
Claudia Mundi, Sebastien Guery, Alberto Buson, Romano Di Fabio, Sergio Melotto, Federico Faggioni, Chiara Savoia, Michela Tessari, Lucilla D'Adamo, Fabio Maria Sabbatini, Carla Di Francesco, Benedetta Perini, Paolo Cavanni, Giovanna Dal Forno, Steve M. Bromidge, Yves St-Denis, Stefania Contini, Mauro Corsi, Elisabetta Perdona, Francesca Pavone, Marilisa Rinaldi, Carpenter Andrew J, Mario Mattioli
Publikováno v:
ChemMedChem. 5:1450-1455
Autor:
Romano Di Fabio, Giovanna Tedesco, Laura Zonzini, Gunther Scheid, Fabrizio Micheli, Ornella Perini, Beatrice Oliosi, Michela Bettati, Paolo Cavanni
Publikováno v:
ChemMedChem. 5:361-366
Autor:
Marika Arduin, Erika Marzola, Paolo Cavanni, Girolamo Calo, Corrado Corti, Anna Rizzi, Prisca Martinelli, Mauro Corsi, Domenico Regoli, Claudio Trapella, Raffaella Vergura, Remo Guerrini, Severo Salvadori, Adelheid Roth
Publikováno v:
Journal of Biological Chemistry. 281:20809-20816
Neuropeptide S (NPS) has been recently recognized as the endogenous ligand for the previous orphan G-protein-coupled receptor GPR154, now referred to as the NPS receptor (NPSR). The NPS-NPSR receptor system regulates important biological functions su
Autor:
Girolamo Calo, Adelheid Roth, Erika Marzola, David J. Rowbotham, Domenico Regoli, Valeria Camarda, David G. Lambert, Wei Song, Remo Guerrini, Stephen A. Douglas, Severo Salvadori, Raffaella Vergura, Martina Spagnol, Jonathan P. Thompson, Paolo Cavanni
Publikováno v:
British Journal of Pharmacology. 147:92-100
The novel urotensin-II (U-II) receptor (UT) ligand, [Pen(5),DTrp(7),Dab(8)]U-II(4-11) (UFP-803), was pharmacologically evaluated and compared with urantide in in vitro and in vivo assays. In the rat isolated aorta, UFP-803 was inactive alone but, con
Autor:
M. Bianchi, Laurent Lacroix, Rosaria Remelli, Stefania Faedo, Elisabetta Perdona, Francesco Crespi, Christian Heidbreder, Paolo Cavanni
Publikováno v:
Synapse. 50:269-276
The mechanisms through which blockade of metabotropic glutamate receptors 5 (mGluR5) results in anxiolytic and antidepressant effects are currently unknown. In the present study, we therefore hypothesized that the anxiolytic- and antidepressant-like
Autor:
Fabio Maria Sabbatini, Daniele Donati, Stefania Faedo, Carla Marchioro, Fabrizio Micheli, Monica Viziano, Sylvie Gehanne, Giorgio Tarzia, Micaela Maffeis, Maria Elvira Tranquillini, Paolo Cavanni, Romano Di Fabio
Publikováno v:
Il Farmaco. 58:1005-1009
Following the disclosure of 3-(1,2,2-trimethylpropyl) 4-[3,5-dimethyl-2-propyloxycarbonyl]pyrrolecarboxylate as a potent and selective mGluR1 non-competitive antagonist, the role and the importance of the pyrrole template were investigated. Different