Výsledky vyhledávání - "Paolo Bovicelli"

New chiral amino alcohol ligands for catalytic enantioselective addition of diethylzincs to aldehydes

Autor: Carla Sappino, Mauro Moliterno, Alessandra Mari, Alessandra Ricelli, Lorenza Suber, Giuliana Righi, Matteo Palagri, Chiara Tatangelo, Paolo Bovicelli, Agnese Mantineo

Publikováno v: Organic & biomolecular chemistry 16 (2018): 1860–1870. doi:10.1039/c8ob00165k
info:cnr-pdr/source/autori:Sappino C.; Mari A.; Mantineo A.; Moliterno M.; Palagri M.; Tatangelo C.; Suber L.; Bovicelli P.; Ricelli A.; Righi G./titolo:New chiral amino alcohol ligands for catalytic enantioselective addition of diethylzincs to aldehydes/doi:10.1039%2Fc8ob00165k/rivista:Organic & biomolecular chemistry/anno:2018/pagina_da:1860/pagina_a:1870/intervallo_pagine:1860–1870/volume:16
Organic & biomolecular chemistry 16 (2018): 1860–1870. doi:10.1039/C8OB00165K
info:cnr-pdr/source/autori:Carla Sappino a, Alessandra Mari a, Agnese Mantineo a, Mauro Moliterno a, Matteo Palagri a, Chiara Tatangelo a, Lorenza Suber b, Paolo Bovicelli c, Alessandra Ricelli c, and Giuliana Righi *c/titolo:New chiral amino alcohol ligands for catalytic enantioselective addition of diethylzincs to aldehydes/doi:10.1039%2FC8OB00165K/rivista:Organic & biomolecular chemistry/anno:2018/pagina_da:1860/pagina_a:1870/intervallo_pagine:1860–1870/volume:16

A study aimed at the synthesis and structure optimization of new, efficient, optically active β-amino alcohol ligands with a structure suitable for immobilization on magnetite nanoparticles has been carried out. The optimized homogeneous amino alcoh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603084f1eb7ce1b93d013bf7bb491d42
https://doi.org/10.1039/c8ob00165k

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Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells

Autor: Giuliana Righi, Vikineswary Sabaratnam, Chia-Wei Phan, Luciano Saso, Paolo Bovicelli

Publikováno v: BioFactors. 42:591-599

Negletein has been shown to have therapeutic potential for inflammation-associated diseases, but its effect on neurite outgrowth is still unknown. The present study showed that negletein alone did not trigger PC12 cells to differentiate and extend ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36d3ceba0c65a4d6fabd2fbe2c8cdf31
https://doi.org/10.1002/biof.1296

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Double Stereodifferentiation in the Asymmetric Dihydroxylation of Optically Active Olefins

Autor: Giuliana Righi, Paolo Bovicelli, Emanuela Mandic, Carla Sappino, Ilaria Tirotta

Publikováno v: Chirality. 28:387-393

A study of the stereochemical control on the asymmetric dihydroxylation of the double bond of optically active vinyl epoxides and their derivatives (bromo derivatives, azido derivatives, and vinyl aziridines) was carried out and the obtained results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd65dc2293ef07260b45034b42e64459
https://doi.org/10.1002/chir.22587

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Synthesis of potential HIV integrase inhibitors inspired by natural polyphenol structures

Autor: Gustavo Portalone, Martina Marini, Paolo Bovicelli, Giuliana Righi, Valerio Isoni, Roberto Dallocchio, Alessandro Dessì, Beatrice Macchi, Antonella Dalla Cort, Matteo Palagri, Ilaria Tirotta, Gianpiero Forte, Caterina Frezza, Romina Pelagalli

Publikováno v: Natural product research
32 (2018): 1893–1901. doi:10.1080/14786419.2017.1354191
info:cnr-pdr/source/autori:Righi G.; Pelagalli R.; Isoni V.; Tirotta I.; Marini M.; Palagri M.; Dallocchio R.; Dessì A.; Macchi B.; Frezza C.; Forte G.; Dalla Cort A.; Portalone G.; Bovicelli P./titolo:Synthesis of potential HIV integrase inhibitors inspired by natural polyphenol structures/doi:10.1080%2F14786419.2017.1354191/rivista:Natural product research (Print)/anno:2018/pagina_da:1893/pagina_a:1901/intervallo_pagine:1893–1901/volume:32

Drawing inspiration from the structural features of some natural polyphenols, the synthesis of two different model compounds as potential inhibitors of HIV integrase (IN) has been described. The former was characterised by a diketo acid (DKA) bioisos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0717f162477a583262f26b9c72e56117
https://pubmed.ncbi.nlm.nih.gov/28748719

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Synthesis, molecular modeling and biological evaluation of two new chicoric acid analogs

Autor: Alessandro Dessì, Roberto Dallocchio, Beatrice Macchi, Valerio Isoni, Paolo Bovicelli, Caterina Frezza, Ilaria Rossetti, Romina Pelagalli, Ilaria Tirotta, Giuliana Righi

Publikováno v: Natural product research (Online) 31 (2017): 397–403. doi:10.1080/14786419.2016.1169413
info:cnr-pdr/source/autori:G. Righi, R. Pelagalli, V. Isoni, I. Trotta, R. Dallocchio, A. Dessì, B.Macchi, C. Frezza, I. Rossetti, P. Bovicelli/titolo:Synthesis, molecular modelling and biological evaluation of two new chicoric acid analogs/doi:10.1080%2F14786419.2016.1169413/rivista:Natural product research (Online)/anno:2017/pagina_da:397/pagina_a:403/intervallo_pagine:397–403/volume:31

Two conformationally constrained compounds similar to chicoric acid but lacking the catechol and carboxyl groups were prepared. In these analogues, the single bond between the two caffeoyl fragments has been replaced with a chiral oxirane ring and bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9101327693187be5f240ef719c50fc
http://hdl.handle.net/2108/162631

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Multiple Mechanisms of Iron-Induced Amyloid Beta-Peptide Accumulation in SHSY5Y Cells: Protective Action of Negletein

Autor: Priyanjalee Banerjee, Sasanka Chakrabarti, Shruti Anand, Giuliana Righi, Luciano Saso, Arghyadip Sahoo, Paolo Bovicelli, Anirban Ganguly

Publikováno v: NeuroMolecular Medicine. 16:787-798

The increased accumulation of iron in the brain in Alzheimer's disease (AD) is well documented, and excess iron is strongly implicated in the pathogenesis of the disease. The adverse effects of accumulated iron in AD brain may include the oxidative s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e640fbae323a647234b7e5ca911aff3c
https://doi.org/10.1007/s12017-014-8328-4

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Asymmetric routes toward polyhydroxylated pyrrolidines: Synthesis of 1,4-dideoxy-1,4-imino-d-galactitol and 1,4-dideoxy-1,4-imino-d-glucitol

Autor: Emanuela Mandic, Paolo Bovicelli, Ergys Dema, Giuliana Righi, Carla Sappino

Publikováno v: Carbohydrate research. 435

Herein the total synthesis of the pyrrolidine alkaloids 1,4-dideoxy-1,4-imino-d-galactitol and its diastereoisomer 1,4-dideoxy-1,4-imino-d-glucitol is described, starting from a common optically active precursor. The key step in our approach was the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2513dacb5a2db6157537c50feac0affa
https://pubmed.ncbi.nlm.nih.gov/27736666

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Stereoselective synthesis of (+)-1-deoxyaltronojirimycin

Autor: Ilaria Tirotta, Carla Sappino, Emanuela Mandic, Paolo Bovicelli, Giuliana Righi, Michela Tomei, Gaia Naponiello, Cristina Marucci

A stereocontrolled, facile and high-yield approach for producing (+)-altroDNJ, has been developed starting from the inexpensive commercial cis 2-butene-1,4-diol. Sharpless epoxidation and a subsequent dihydroxylation were used for the introduction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca6d2e8107a2b1e613e9d6ed765f57d

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