Výsledky vyhledávání - "Paolo, Scartezzini"

Akademický článek

SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line

Autor: Filippo Di Pisa, Elisa Pesenti, Maria Bono, Andrea N. Mazzarello, Cinzia Bernardi, Michael P. Lisanti, Giovanni Renzone, Andrea Scaloni, Ermanno Ciccone, Franco Fais, Silvia Bruno, Paolo Scartezzini, Fabio Ghiotto

Publikováno v: BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-12 (2021)

Abstract Background The human SH3 domain Binding Glutamic acid Rich Like 3 (SH3BGRL3) gene is highly conserved in phylogeny and widely expressed in human tissues. However, its function is largely undetermined. The protein was found to be overexpresse

Externí odkaz: https://doaj.org/article/bdaeeebccdf8400995bd192ebe53393f

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SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line

Autor: Elisa Pesenti, Ermanno Ciccone, Fabio Ghiotto, Andrea Scaloni, Cinzia Bernardi, Silvia Bruno, Michael P. Lisanti, Giovanni Renzone, Maria Bono, Paolo Scartezzini, Andrea Nicola Mazzarello, Filippo Di Pisa, Franco Fais

Publikováno v: BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-12 (2021)
BMC Molecular and Cell Biology
BMC molecular and cell biology On line 22 (2021). doi:10.1186/s12860-021-00379-1
info:cnr-pdr/source/autori:Di Pisa F.; Pesenti E.; Bono M.; Mazzarello A.N.; Bernardi C.; Lisanti M.P.; Renzone G.; Scaloni A.; Ciccone E.; Fais F.; Bruno S.; Scartezzini P.; Ghiotto F./titolo:SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line/doi:10.1186%2Fs12860-021-00379-1/rivista:BMC molecular and cell biology On line/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22

BackgroundThe humanSH3 domain Binding Glutamic acid Rich Like 3(SH3BGRL3) gene is highly conserved in phylogeny and widely expressed in human tissues. However, its function is largely undetermined. The protein was found to be overexpressed in several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d5d02c80321769f7cc864e01222852
https://usir.salford.ac.uk/id/eprint/61488/2/12860_2021_Article_379.pdf

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Akademický článek

Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug.

Autor: Carmela Fimognari, Monia Lenzi, Lorenzo Ferruzzi, Eleonora Turrini, Paolo Scartezzini, Ferruccio Poli, Roberto Gotti, Alessandra Guerrini, Giovanni Carulli, Virginia Ottaviano, Giorgio Cantelli-Forti, Patrizia Hrelia

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e21544 (2011)

BackgroundAlthough cancers are characterized by the deregulation of multiple signalling pathways, most current anticancer therapies involve the modulation of a single target. Because of the enormous biological diversity of cancer, strategic combinati

Externí odkaz: https://doaj.org/article/4e3bde503cee4dad83e92a263aec10ea

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A Vector Design that Allows Fast and Convenient Production of Differently Tagged Proteins

Autor: Marco Bestagno, Fabio Ghiotto, Silvia Bruno, Marzia Occhino, Andrea Nicola Mazzarello, Paolo Scartezzini, Franco Fais, Omar Scapolan, Maria Bono, Vasily Ogryzko

Publikováno v: Molecular Biotechnology. 52:16-25

Recombinant-tagged proteins have a widespread use in experimental research as well as in clinical diagnostic and therapeutic approaches. Well-stocked sets of differently tagged variants of a same protein would be of great help. However, the construct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8c78d92452726f646455a9392a6050
https://doi.org/10.1007/s12033-011-9469-4

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Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

Autor: Riccardo S. Merafina, Paolo Scartezzini, Rosa Anna Vacca, Ersilia Marra, Daniela Valenti, Mariano Francesco Caratozzolo, Apollonia Tullo

Publikováno v: Biochemical Journal. 431:299-310

A central role for mitochondrial dysfunction has been proposed in the pathogenesis of DS (Down's syndrome), a multifactorial disorder caused by trisomy of human chromosome 21. To explore whether and how abnormalities in mitochondrial energy metabolis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f21597445872b1f53e4378ab283138
https://doi.org/10.1042/bj20100581

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The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily

Autor: Alessandro Vergano, Fabio Ghiotto, Paolo Scartezzini, Patrizio Arrigo, Aliana Egeo, Massimo E. Maffei, Michela Mazzocco, Raffaella Di Lisi

Publikováno v: Gene (Amst.) 291 (2002): 233–239.
info:cnr-pdr/source/autori:Mazzocco M., Maffei M., Egeo A., Vergano A., Arrigo P., Di Lisi R., Ghiotto F., Scartezzini P./titolo:The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily/doi:/rivista:Gene (Amst.)/anno:2002/pagina_da:233/pagina_a:239/intervallo_pagine:233–239/volume:291

The SH3 binding glutamic acid-rich (SH3BGR) gene was cloned in an effort to identify genes located to human chromosome 21, within the congenital heart disease region, and expressed in the developing heart. After the identification of SH3BGR, two huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35fafaff854792bea238f05648f71d36
https://doi.org/10.1016/s0378-1119(02)00602-9

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Identification and Characterization of a New Gene from Human Chromosome 21 between Markers D21S343 and D21S268 Encoding a Leucine-Rich Protein

Autor: Rafael Oliva, Aliana Egeo, Santiago Sanz, Paolo Scartezzini, Jose M. Vidal-Taboada

Publikováno v: Biochemical and Biophysical Research Communications. 250:547-554

We initiated the present work as part of an effort to identify and characterize genes from the EST2-HMG14 region from human chromosome 21 potentially responsible for some of the Down syndrome (DS) features. Genomic sample sequencing with cosmid clone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9854d7acc704ff7209cfbe6a1c19e8
https://doi.org/10.1006/bbrc.1998.9352

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High Resolution Physical Mapping and Identification of Transcribed Sequences in the Down Syndrome Region-2

Autor: Jürgen Groet, Rafael Oliva, Dean Nizetic, Jean-Maurice Delabar, Elizabeth M. C. Fisher, Nicolas Katsanis, Salvador Bergoñon, Cristina López-Acedo, Jose M. Vidal-Taboada, Paolo Scartezzini, Aliana Egeo, Mayca Sánchez

Publikováno v: Biochemical and Biophysical Research Communications. 243:572-578

The identification and mapping of genes within the Down syndrome region is an important step toward a complete understanding of the pathogenesis of this disorder. The objective of the present work is to identify and map genes within the Down syndrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3637947aff2d01efedb9500e9c8e802
https://doi.org/10.1006/bbrc.1998.8141

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High-Resolution Physical Map and Identification of Potentially Regulatory Sequences of the Human SH3BGR Located in the Down Syndrome Chromosomal Region

Autor: Aliana Egeo, Salvador Bergoñon, Jose M. Vidal-Taboada, Paolo Scartezzini, Rafael Oliva, Dean Nizetic

Publikováno v: Biochemical and Biophysical Research Communications. 241:321-326

We have isolated, mapped and sequenced the 5′ promoter region of the human SH3BGR (SH3-Binding Glutamine Rich) gene located in the Down syndrome region-2, between markers D21S55 and MX1 of human chromosome 21. This region has been postulated as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d0bffffe40e2ad4db4856f284dcb6c
https://doi.org/10.1006/bbrc.1997.7816

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Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region

Autor: Paolo Scartezzini, Claudia Sandri, Elisa Calabria, Raffaella Di Lisi, Kristene Myklak, Carla Argentini, Stefano Schiaffino, Anne Picard

Publikováno v: Human Genetics. 114:517-519

Congenital heart disease (CHD) is the most common birth defect in humans and is present in 40% of newborns affected by Down syndrome (DS). The SH3BGR gene maps to the DS-CHD region and is a potential candidate for the pathogenesis of CHD, since it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53621ab91813f88fe3866c2f2124b227
https://doi.org/10.1007/s00439-004-1088-8

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