Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Paolo, Mignatti"'
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism
Autor:
Mukundan Attur, Cuijie Lu, Xiaodong Zhang, Tianzhen Han, Cassidy Alexandre, Cristina Valacca, Shuai Zheng, Sarina Meikle, Branka Brukner Dabovic, Evelyne Tassone, Qing Yang, Victoria Kolupaeva, Shoshana Yakar, Steven Abramson, Paolo Mignatti
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101789- (2020)
Summary: Membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14), a transmembrane proteinase with a short cytoplasmic tail, is a major effector of extracellular matrix remodeling. Genetic silencing of MT1-MMP in mouse (Mmp14−/−) and man causes
Externí odkaz:
https://doaj.org/article/c75bb8befb1a45eeb5542b86036af6fd
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231501 (2020)
Osteoarthritis (OA) is characterized by progressive loss of articular cartilage accompanied by the new bone formation and, often, a synovial proliferation that culminates in pain, loss of joint function, and disability. However, the cellular and mole
Externí odkaz:
https://doaj.org/article/d80471055d814a9689afcd5235349ec1
Autor:
Paolo Mignatti, Giuseppe Pintucci, Paolo Poggio, Cristina Valacca, Xiaodong Zhang, Martin J. Wolff, Vitaly Terushkin, Giovanni Ferrari
PDF file - 51K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2569fb9d1f17c19f1f434e60936639a0
https://doi.org/10.1158/1541-7786.22517112
https://doi.org/10.1158/1541-7786.22517112
Autor:
Silvia D'Alessio, Francesco Blasi, Paolo Mignatti, Silvio Danese, Alessandro Ambrosi, Chiara Brombin, Davide Moi, Piergiuseppe Colombo, Alessandro Gandelli, Laura Gerasi, Giovanni Pietrogrande, Roberta Mazzieri
This file include Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8ecd719ac820d2ee8fcd6e434eaef6
https://doi.org/10.1158/0008-5472.22410755.v1
https://doi.org/10.1158/0008-5472.22410755.v1
Autor:
Silvia D'Alessio, Francesco Blasi, Paolo Mignatti, Silvio Danese, Alessandro Ambrosi, Chiara Brombin, Davide Moi, Piergiuseppe Colombo, Alessandro Gandelli, Laura Gerasi, Giovanni Pietrogrande, Roberta Mazzieri
The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically reduces su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94acc4489654302f6d747e831b5d5040
https://doi.org/10.1158/0008-5472.c.6508061
https://doi.org/10.1158/0008-5472.c.6508061
Autor:
Silvia D'Alessio, Francesco Blasi, Paolo Mignatti, Silvio Danese, Alessandro Ambrosi, Chiara Brombin, Davide Moi, Piergiuseppe Colombo, Alessandro Gandelli, Laura Gerasi, Giovanni Pietrogrande, Roberta Mazzieri
This file include more detailed Material and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542fe6db2341d6c1cd1508bacc759e7e
https://doi.org/10.1158/0008-5472.22410758
https://doi.org/10.1158/0008-5472.22410758
Autor:
Silvia D'Alessio, Francesco Blasi, Paolo Mignatti, Silvio Danese, Alessandro Ambrosi, Chiara Brombin, Davide Moi, Piergiuseppe Colombo, Alessandro Gandelli, Laura Gerasi, Giovanni Pietrogrande, Roberta Mazzieri
This file include Supplementary Figures S1-7 and Tables S1-2. Figure S1. Inflammation and neo-angiogenesis are not impaired in TPA-treated uPAR-/- skin. Figure S2. Distinct stages of hair cycling in uPAR+/+ and uPAR-/- littermates. Figure S3. FACS is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcccb445ce8fbbf63902449c9f54101
https://doi.org/10.1158/0008-5472.22410752
https://doi.org/10.1158/0008-5472.22410752
Autor:
Michele Silvestro, Cristobal F. Rivera, Dornazsadat Alebrahim, John Vlahos, Muhammad Yogi Pratama, Cuijie Lu, Claudia Tang, Zander Harpel, Rayan Sleiman Tellaoui, Ariadne L. Zias, Delphina J. Maldonado, Devon Byrd, Mukundan Attur, Paolo Mignatti, Bhama Ramkhelawon
Publikováno v:
Arterioscler Thromb Vasc Biol
Background: MT1-MMP (membrane-type 1 matrix metalloproteinase, MMP-14) is a transmembrane-anchored protein with an extracellular proteinase domain and a cytoplasmic tail devoid of proteolytic functions but capable of mediating intracellular signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02eaece2ea3631b2bbbfc0c3a7f9781e
https://europepmc.org/articles/PMC9993845/
https://europepmc.org/articles/PMC9993845/
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136797 (2015)
Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane proteinase with an extracellular catalytic domain and a short cytoplasmic tail, degrades a variety of extracellular matrix (ECM) components. In addition, MT1-MMP activates intracellu
Externí odkaz:
https://doaj.org/article/c856b3d578f640b8867a23f3168ed0be
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism
Autor:
Cuijie Lu, Steven B. Abramson, Evelyne Tassone, Sarina Meikle, Paolo Mignatti, Cassidy Alexandre, Qing X. Yang, Tianzhen Han, Victoria Kolupaeva, Cristina Valacca, Branka Dabovic, Shoshana Yakar, Shuai Zheng, Xiaodong Zhang, Mukundan Attur
Publikováno v:
iScience
iScience, Vol 23, Iss 12, Pp 101789-(2020)
iScience, Vol 23, Iss 12, Pp 101789-(2020)
Summary Membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14), a transmembrane proteinase with a short cytoplasmic tail, is a major effector of extracellular matrix remodeling. Genetic silencing of MT1-MMP in mouse (Mmp14−/−) and man causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d79fe6fc34e152c55fe2b4ccb8ab52c
http://europepmc.org/articles/PMC7695985
http://europepmc.org/articles/PMC7695985