Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Paolo, La Colla"'
Autor:
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S. Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The drug AT-527 targets the SARS-CoV-2 replication machinery. Here the authors use Cryo-EM to show how AT-527 inhibits SARS-CoV-2 polymerase by acting as an immediate RNA chain terminator and stably binding in a NiRAN active-site pocket; impeding an
Externí odkaz:
https://doaj.org/article/10c0996a692f427a8bc1883d8ce5e61e
Autor:
David Collu, Roberta Loddo, Cristina Ibba, Laura Ester Marongiu, Paolo La Colla, Izabela Dybala, Anna E. Koziol, Marta Struga, Jerzy Kossakowski, Magdalena Pakosinska-Parys
Publikováno v:
Molecules, Vol 14, Iss 12, Pp 5189-5202 (2009)
A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active again
Externí odkaz:
https://doaj.org/article/09ccea67bbe9474cbc64bd51680a7cb9
Autor:
Yaseen A. Al-Soud, Haitham H. Al-Sa’doni, Bahjat Saeed, Ihsan H. Jaber, Mohammad O. Beni-Khalid, Najim A. Al-Masoudi, Tahsin Abdul-Kadir, Paolo La Colla, Bernardetta Busonera, Tiziana Sanna, Roberta Loddo
Publikováno v:
ARKIVOC, Vol 2008, Iss 15, Pp 225-238 (2008)
Externí odkaz:
https://doaj.org/article/2cdb9e5a182b43d7856bbb26b8ec0ba3
Autor:
Steven S. Good, Kai Lin, Gabriella Collu, Ashleigh Shannon, Bruno Canard, Paolo La Colla, Adel Moussa, Justin G. Julander, Jean-Pierre Sommadossi
Publikováno v:
Antimicrobial Agents and Chemotherapy
Every year, millions of people worldwide are infected with dengue virus (DENV), with a significant number developing severe life-threatening disease. There are currently no broadly indicated vaccines or therapeutics available for treatment of DENV in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea713249c1156d73c52fb93d5a123c5
http://europepmc.org/articles/PMC8522752
http://europepmc.org/articles/PMC8522752
Autor:
Bhawna Sama, Etienne Decroly, Paolo La Colla, Barbara Selisko, Steven S. Good, Jean-Pierre Sommadossi, Adrien Delpal, Camille Falcou, Adel Moussa, Kai Lin, Hui Shi, Ashleigh Shannon, Bruno Canard, Cécilia Eydoux, Yingxao Zhu, Karine Alvarez, Pierre Gauffre, Xiaodong Yan, Veronique Fattorini, Priscila El-Kazzi, Mikael Feracci, François Ferron, Jean-Claude Guillemot
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Nature Communications
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩
Nature Communications
Nature Communications, 2022, 13, ⟨10.1038/s41467-022-28113-1⟩
A worldwide effort is ongoing to discover drugs against the Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2), which has so far caused >3.5 million fatalities (https://covid19.who.int/). The virus essential RNA-dependent RNA polymeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14f01f1609abb1a795a7309150f5ca4
https://doi.org/10.21203/rs.3.rs-624370/v1
https://doi.org/10.21203/rs.3.rs-624370/v1
Autor:
Isabel Gomez-Monterrey, Pietro Campiglia, Teresa Lama, Paolo La Colla, Maria V. Diurno, Paolo Grieco, Ettore Novellino
Publikováno v:
ARKIVOC, Vol 2004, Iss 5, Pp 85-96 (2004)
Externí odkaz:
https://doaj.org/article/8a11237ee24c491193e4d5866ededbb7
Autor:
Steven S, Good, Jonna, Westover, Kie Hoon, Jung, Xiao-Jian, Zhou, Adel, Moussa, Paolo, La Colla, Gabriella, Collu, Bruno, Canard, Jean-Pierre, Sommadossi
Publikováno v:
Antimicrobial Agents and Chemotherapy
The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, is global and unprecedented. Although remdesivir has recently been approved by the FDA to treat SARS-CoV-2 infection, no oral antiviral is av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b769c49dbcec6b24d3219b74738b52d6
https://pubmed.ncbi.nlm.nih.gov/33558299
https://pubmed.ncbi.nlm.nih.gov/33558299
Autor:
Gabriella Collu, Jonna B. Westover, Adel Moussa, Steven S. Good, Paolo La Colla, Jean-Pierre Sommadossi, Bruno Canard, Kie Hoon Jung
AT-527, an orally administered double prodrug of a guanosine nucleotide analog, has been shown previously to be highly efficacious and well tolerated in HCV-infected subjects. Herein we report the potent in vitro activity of AT-511, the free base for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::999861132a49f5ac0158e0ebaeac09d9
https://doi.org/10.1101/2020.08.11.242834
https://doi.org/10.1101/2020.08.11.242834
Publikováno v:
Archiv der Pharmazie. 349:363-372
Some novel MC-1220 analogs were synthesized by condensation of 4,6-dichloro-N-methylpyrimidin-2-amine derivatives (1a,b and 15) and/or 4-chloro-6-methoxy-N,N,5-trimethylpyrimidin-2-amine (2a) with the sodium salt of 2,6-difluorophenylacetonitrile fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce39814d45edc5e03202583f7ec3c36b
https://doi.org/10.1002/ardp.201600008
https://doi.org/10.1002/ardp.201600008
Publikováno v:
Loksha, Y M, Pedersen, E B, La Colla, P & Loddo, R 2016, ' Facile synthesis of the NNRTI microbicide MC-1220 and synthesis of its phosphoramidate prodrugs ', Organic & Biomolecular Chemistry, vol. 14, no. 3, pp. 940-946 . https://doi.org/10.1039/c5ob02055g
A facile and novel synthetic route to MC-1220 was achieved by condensation of 4,6-dichloro-N,N-5-trimethylpyrimidin-2-amine () with the sodium salt of 2,6-difluorophenylacetonitrile, followed by methylation and strong acidic hydrolysis. The prodrugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cca24de800ad8b173ed30f6ea10cb34
https://doi.org/10.1039/c5ob02055g
https://doi.org/10.1039/c5ob02055g