Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Paolo, Guglielmi"'
Autor:
Paolo Guglielmi, Gaia Pulitelli, Francesca Arrighi, Daniela Secci, Marco Pierini, Roberto Cirilli
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 696 (2024)
Mebendazole (MBZ) is a benzimidazole carbamate anthelmintic used worldwide for the treatment and prevention of parasitic disorders in animals and humans. A large number of in vivo and in vitro studies have demonstrated that MBZ also has anticancer ac
Externí odkaz:
https://doaj.org/article/e2c8ed2168bb4c71a89749d93b5843c5
Publikováno v:
Energies, Vol 17, Iss 5, p 984 (2024)
The electrification of transport is expected to progressively replace significant shares of light duty mobility, especially in large cities. The European Alternative Fuel Infrastructure Regulation (AFIR) aims to drive the adoption of electric mobilit
Externí odkaz:
https://doaj.org/article/ed49bca938934136b155d50afcb69bd9
Autor:
Emanuela Berrino, Simone Carradori, Fabrizio Carta, Francesco Melfi, Marialucia Gallorini, Giulio Poli, Tiziano Tuccinardi, José G. Fernández-Bolaños, Óscar López, Jacobus P. Petzer, Anél Petzer, Paolo Guglielmi, Daniela Secci, Claudiu T. Supuran
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2044 (2023)
Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial etiology. The most common NDs are Alzheimer’s disease and Parkinson’s disease, in which cholinergic and dopaminergic sys
Externí odkaz:
https://doaj.org/article/b5a1744f71ab47be8afc72bbec67ca7a
Publikováno v:
Molecules, Vol 28, Iss 18, p 6518 (2023)
Isoxazoline is a nitrogen- and oxygen-containing five-membered heterocyclic scaffold with diverse biological profiles such as antimicrobial, fungicidal, anticancer, antiviral, analgesic and anti-inflammatory activity. Accordingly, the use of this pec
Externí odkaz:
https://doaj.org/article/f2cc48b8db774d2da9a00874546cdc13
Autor:
Paolo Guglielmi, Giulia Rotondi, Daniela Secci, Andrea Angeli, Paola Chimenti, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Simone Carradori, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1891-1905 (2020)
A large library of saccharin and acesulfame derivatives has been synthesised and evaluated against four isoforms of human carbonic anhydrase, the two off-targets hCA I/II and the tumour related isoforms hCA IX/XII. Different strategies of scaffold mo
Externí odkaz:
https://doaj.org/article/78a54a75d73d42d58de2a564f1317cc7
Autor:
Serena Veschi, Simone Carradori, Laura De Lellis, Rosalba Florio, Davide Brocco, Daniela Secci, Paolo Guglielmi, Mattia Spano, Anatoly P. Sobolev, Alessandro Cama
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1331-1344 (2020)
Pancreatic cancer (PC) is one of the deadliest carcinomas and in most cases, which are diagnosed with locally advanced or metastatic disease, current therapeutic options are highly unsatisfactory. Based on the anti-proliferative effects shown by nitr
Externí odkaz:
https://doaj.org/article/c4b1c4205bdc44fa8cc1036ae680c3ce
Autor:
Paolo Guglielmi, Daniela Secci, Anél Petzer, Donatella Bagetta, Paola Chimenti, Giulia Rotondi, Claudio Ferrante, Lucia Recinella, Sheila Leone, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso, Simone Carradori
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1511-1525 (2019)
A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPA
Externí odkaz:
https://doaj.org/article/7280406604314cb88e2b4f9137207ce4
Autor:
Daniela Secci, Simone Carradori, Anél Petzer, Paolo Guglielmi, Melissa D’Ascenzio, Paola Chimenti, Donatella Bagetta, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 597-612 (2019)
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substitu
Externí odkaz:
https://doaj.org/article/5a66b83f76a94eb594765e493cf83d5e
Autor:
Giulia Rotondi, Paolo Guglielmi, Simone Carradori, Daniela Secci, Celeste De Monte, Barbara De Filippis, Cristina Maccallini, Rosa Amoroso, Roberto Cirilli, Atilla Akdemir, Andrea Angeli, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1400-1413 (2019)
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration
Externí odkaz:
https://doaj.org/article/0d950a7741db47cf897a69d1aff65d30
Publikováno v:
Energies, Vol 15, Iss 14, p 5079 (2022)
This paper presents the modeling, the design and verification of a three-phase coil structure for high-power Wireless-Power-Transfer (WPT) in automotive applications. The system, a Three-Polar-Pad (TPP), with complex mechanical geometry, is analytica
Externí odkaz:
https://doaj.org/article/5126f4d4674e472c9d0dca97d61176f3