Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Paolo, Fortina"'
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106304- (2023)
Summary: In mature bone, NGF is produced by osteoblasts following mechanical loading and signals through resident sensory nerves expressing its high affinity receptor, neurotrophic tyrosine kinase receptor type 1 (TrkA), to support bone formation. He
Externí odkaz:
https://doaj.org/article/14cacedd9c874f3095cc7b44f07114d3
Autor:
Bahar Dasgeb, Youssefian Leila, Amir Hossein Saeidian, Jun Kang, Wenyin Shi, Elizabeth Shoenberg, Adam Ertel, Paolo Fortina, Hassan Vahidnezhad, Jouni Uitto
Publikováno v:
International Journal of Dermatology and Venerology, Vol 4, Iss 2, Pp 70-75 (2021)
Abstract. Objective:. Well-defined germ-line mutations in the PTCH1 gene are associated with syndromic multiple basal cell carcinomas (BCCs). Here, we used whole exome sequencing (WES) to identify the role of patched-1 in patients with multiple, unus
Externí odkaz:
https://doaj.org/article/2a95672cb3a3409fa0fed6cf529f1a03
Autor:
Javad Rasouli, Giacomo Casella, Weifeng Zhang, Dan Xiao, Gaurav Kumar, Paolo Fortina, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
GM-CSF-producing T helper (Th) cells play a crucial role in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). Recent studies have identified a distinct population of GM-CSF-producing Th cells, named ThGM cells, that also expres
Externí odkaz:
https://doaj.org/article/d37972e517d44559ab77f8964d478ce0
Autor:
Amir Hossein Saeidian, Leila Youssefian, Charles Y. Huang, Fahimeh Palizban, Mahtab Naji, Zahra Saffarian, Hamidreza Mahmoudi, Azadeh Goodarzi, Soheila Sotoudeh, Fatemeh Vahidnezhad, Maliheh Amani, Narjes Tavakoli, Ali Ajami, Samaneh Mozafarpoor, Mehrdad Teimoorian, Saeed Dorgaleleh, Sima Shokri, Mohammad Shenagari, Nima Abedi, Sirous Zeinali, Paolo Fortina, Vivien Béziat, Emmanuelle Jouanguy, Jean-Laurent Casanova, Jouni Uitto, Hassan Vahidnezhad
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Severe viral infections of the skin can occur in patients with inborn errors of immunity (IEI). We report an all-in-one whole-transcriptome sequencing–based method by RNA-Seq on a single skin biopsy for concomitantly identifying the cutaneous virom
Externí odkaz:
https://doaj.org/article/7c4da489857e4de18b1fdb84470b1f82
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Quality Control in any high-throughput sequencing technology is a critical step, which if overlooked can compromise an experiment and the resulting conclusions. A number of methods exist to identify biases during sequencing or ali
Externí odkaz:
https://doaj.org/article/224e77a8713640abb35ef3231a474838
Autor:
Javad Rasouli, Giacomo Casella, Larissa L. W. Ishikawa, Rodolfo Thome, Alexandra Boehm, Adam Ertel, Carolina R. Melo-Silva, Elisabeth R. Mari, Patrizia Porazzi, Weifeng Zhang, Dan Xiao, Luis J. Sigal, Paolo Fortina, Guang-Xian Zhang, Abdolmohamad Rostami, Bogoljub Ciric
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but understanding the mechanisms underlying its beneficial effects remains incomplete. We have shown that MS patients have increased numbers of GM-CSF+ Th cells in ci
Externí odkaz:
https://doaj.org/article/5b73622522934dc1a2b4a1b2ed9a906b
Autor:
Fabio Quaglia, Shiv Ram Krishn, George G. Daaboul, Srawasti Sarker, Raffaella Pippa, Josep Domingo-Domenech, Gaurav Kumar, Paolo Fortina, Peter McCue, William K. Kelly, Himisha Beltran, Qin Liu, Lucia R. Languino
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
The ability of small extracellular vesicles (sEVs) to reprogram cancer cells is well established. However, the specific sEV components able to mediate aberrant effects in cancer cells have not been characterized. Integrins are major players in mediat
Externí odkaz:
https://doaj.org/article/a987d4b64c7241bcbd7735801cedadae
Autor:
Ken Kageyama, Masahiro Ohara, Kengo Saito, Shinji Ozaki, Mizue Terai, Michael J. Mastrangelo, Paolo Fortina, Andrew E. Aplin, Takami Sato
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-19 (2017)
Abstract Background Metastatic uveal melanoma is a highly fatal disease; most patients die from their hepatic metastasis within 1 year. A major drawback in the development of new treatments for metastatic uveal melanoma is the difficulty in obtaining
Externí odkaz:
https://doaj.org/article/fee483d021fb42bbabf7d2e51c39de4c
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Table 4: Genes down-regulated (> 2-fold) by Stat5-shRNA and IST5-002 in K562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b04c76a8e28cb2743713cf60d3ca3b6
https://doi.org/10.1158/1535-7163.22501908.v1
https://doi.org/10.1158/1535-7163.22501908.v1
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Methods. Supplementary Figure 1. Chemical structures of the small molecule IST5-002 analogs. Supplementary Figure 2. IST5-002 inhibits phosphorylation of Stat5 in mouse and human breast cancer cells. Supplementary Figure 3. IST5-002 doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e3dfff6a37fe75ab4144213045f901
https://doi.org/10.1158/1535-7163.22501902.v1
https://doi.org/10.1158/1535-7163.22501902.v1