Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Paolo, Ambrosino"'
Autor:
Ilaria Mosca, Elena Freri, Paolo Ambrosino, Giorgio Belperio, Tiziana Granata, Laura Canafoglia, Francesca Ragona, Roberta Solazzi, Ilaria Filareto, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Jacopo C. DiFrancesco, Maria Virginia Soldovieri, Maurizio Taglialatela
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Variants in KCNT1 are associated with a wide spectrum of epileptic phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), non-EIMFS developmental and epileptic encephalopathies, autosomal dominant or sporadic sleep-related h
Externí odkaz:
https://doaj.org/article/bb28e5e73dc348f28be4039a009a995c
Autor:
Francesco Miceli, Charissa Millevert, Maria Virginia Soldovieri, Ilaria Mosca, Paolo Ambrosino, Lidia Carotenuto, Dewi Schrader, Hyun Kyung Lee, James Riviello, William Hong, Sarah Risen, Lisa Emrick, Hitha Amin, Dorothée Ville, Patrick Edery, Julitta de Bellescize, Vincent Michaud, Julien Van-Gils, Cyril Goizet, Marjolein H. Willemsen, Tjitske Kleefstra, Rikke S Møller, Allan Bayat, Orrin Devinsky, Tristan Sands, G. Christoph Korenke, Gerhard Kluger, Heather C. Mefford, Eva Brilstra, Gaetan Lesca, Mathieu Milh, Edward C. Cooper, Maurizio Taglialatela, Sarah Weckhuysen
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104130- (2022)
Summary: Background: Prior studies have revealed remarkable phenotypic heterogeneity in KCNQ2-related disorders, correlated with effects on biophysical features of heterologously expressed channels. Here, we assessed phenotypes and functional propert
Externí odkaz:
https://doaj.org/article/27289a7516ba4ba9b422fb966fcb4594
Autor:
Ilaria Mosca, Ilaria Rivolta, Audrey Labalme, Paolo Ambrosino, Barbara Castellotti, Cinzia Gellera, Tiziana Granata, Elena Freri, Anna Binda, Gaetan Lesca, Jacopo C. DiFrancesco, Maria Virginia Soldovieri, Maurizio Taglialatela
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Pathogenic variants in KCNQ2 encoding for Kv7.2 potassium channel subunits have been found in patients affected by widely diverging epileptic phenotypes, ranging from Self-Limiting Familial Neonatal Epilepsy (SLFNE) to severe Developmental and Epilep
Externí odkaz:
https://doaj.org/article/748e8ad004ae4546ab0b3b0ff6a1ecdb
Autor:
Alessandro Alaimo, Marco Lorenzoni, Paolo Ambrosino, Arianna Bertossi, Alessandra Bisio, Alice Macchia, Eugenio Zoni, Sacha Genovesi, Francesco Cambuli, Veronica Foletto, Dario De Felice, Maria Virginia Soldovieri, Ilaria Mosca, Francesco Gandolfi, Matteo Brunelli, Gianluca Petris, Anna Cereseto, Alvaro Villarroel, George Thalmann, Francesco Giuseppe Carbone, Marianna Kruithof-de Julio, Mattia Barbareschi, Alessandro Romanel, Maurizio Taglialatela, Andrea Lunardi
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-17 (2020)
Abstract Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer
Externí odkaz:
https://doaj.org/article/df6bf34ea7084a21b91211d2e2dccd09
Autor:
Domenico Maurizio Toraldo, Francesco Satriano, Rodolfo Rollo, Gabriella Verdastro, Giovanni Imbriani, Emanuele Rizzo, Alberto Argentiero, Andrea Falco, Paolo Ambrosino, Alessandro Miani, Prisco Piscitelli
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Background COVID-19 pandemic resulted in about 165 million infections and 3.4 million deaths all over the world across 15 months. The most severe clinical presentation of COVID-19 diseases is interstitial pneumonia. Methods In this paper we describe
Externí odkaz:
https://doaj.org/article/d6e5ddb013a34233a2d10bc5b866b76c
Autor:
Anna Lauritano, Sebastien Moutton, Elena Longobardi, Frédéric Tran Mau‐Them, Giusy Laudati, Piera Nappi, Maria Virginia Soldovieri, Paolo Ambrosino, Mauro Cataldi, Thibaud Jouan, Daphné Lehalle, Hélène Maurey, Christophe Philippe, Francesco Miceli, Antonio Vitobello, Maurizio Taglialatela
Publikováno v:
Epilepsia Open, Vol 4, Iss 3, Pp 464-475 (2019)
Abstract Objective Heterozygous variants in KCNQ2 or, more rarely, KCNQ3 genes are responsible for early‐onset developmental/epileptic disorders characterized by heterogeneous clinical presentation and course, genetic transmission, and prognosis. W
Externí odkaz:
https://doaj.org/article/97250fe42ada46c4b9c58256134bf79c
Autor:
Alvaro Villarroel, Carolina Gomis-Perez, Maria V. Soldovieri, Covadonga Malo, Paolo Ambrosino, Maurizio Taglialatela, Pilar Areso
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
HIGHLIGHTS- Calmodulin-dependent Kv7.2 current density without the need of binding calcium.- Kv7.2 current density increase is accompanied with resistance to PI(4,5)P2 depletion.- Kv7.3 current density is insensitive to calmodulin elevation.- Kv7.3 i
Externí odkaz:
https://doaj.org/article/f109c741dcd64703a5ee752807ae837a
Autor:
Mario, Nappi, Vincenzo, Barrese, Lidia, Carotenuto, Gaetan, Lesca, Audrey, Labalme, Dorothee, Ville, Thomas, Smol, Mélanie, Rama, Anne, Dieux-Coeslier, Clotilde, Rivier-Ringenbach, Maria Virginia, Soldovieri, Paolo, Ambrosino, Ilaria, Mosca, Michael, Pusch, Francesco, Miceli, Maurizio, Taglialatela
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(15)
Developmental and epileptic encephalopathies (DEEs) are neurodevelopmental diseases characterized by refractory epilepsy, distinct electroencephalographic and neuroradiological features, and various degrees of developmental delay. Mutations in KCNQ2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72cb73f55976c58a302bddcabaa3b6df
https://pubmed.ncbi.nlm.nih.gov/35377796
https://pubmed.ncbi.nlm.nih.gov/35377796
Autor:
Francesco Miceli, Maurizio Taglialatela, Piera Nappi, Vincenzo Barrese, Maria Virginia Soldovieri, Paolo Ambrosino
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 472:881-898
Seizures are the most common neurological manifestation in the newborn period, with an estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a detrimental effect on cognition and brain function in experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090f8392984757182af8b3033a239961
https://doi.org/10.1007/s00424-020-02404-2
https://doi.org/10.1007/s00424-020-02404-2
Autor:
Gianluca Paventi, Maria Virginia Soldovieri, Ilenio Servettini, Vincenzo Barrese, Francesco Miceli, Maria Josè Sisalli, Paolo Ambrosino, Ilaria Mosca, Iolanda Vinciguerra, Lara Testai, Antonella Scorziello, Gennaro Raimo, Vincenzo Calderone, Salvatore Passarella, Maurizio Taglialatela
Mitochondrial K+ permeability regulates neuronal apoptosis, energy metabolism, autophagy, and protection against ischemia–reperfusion injury. Kv7.4 channels have been recently shown to regulate K+ permeability in cardiac mitochondria and exert card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d68172cd580b67b8431cd36679e1d7
http://hdl.handle.net/11588/873157
http://hdl.handle.net/11588/873157
