Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients

Autor: Paolicchi, E., Vivaldi, C., De Gregorio, V., Crea, F., Fornaro, L., Masi, G., Loupakis, F., Graziano, F., Ronzoni, M., Ricci, V., Falcone, A., Danesi, R.

Objective: Topoisomerase 1 (topo-1) is an important target for the treatment of metastatic colorectal cancer (CRC). The aim of the present study was to evaluate the correlation between topo-1 single-nucleotide polymorphisms (SNPs) and clinical outcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3a6b094140718341500fc84d868d6715
http://oro.open.ac.uk/48042/1/Oncology_ORO.pdf

Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas.

Autor: Cruz, Perla¹ (AUTHOR) dfigueroa@cienciavida.org, Peña-Lopez, Diego¹ (AUTHOR) alladser@cienciavida.org, Figueroa, Diego¹ (AUTHOR), Riobó, Isidora¹ (AUTHOR), Benedetti, Vincenzo¹ (AUTHOR), Saavedra, Francisco¹ (AUTHOR), Espinoza-Arratia, Claudia¹ (AUTHOR), Escobar, Thelma M.^2,3 (AUTHOR), Lladser, Alvaro^1,4 (AUTHOR), Loyola, Alejandra^1,4 (AUTHOR) aloyola@cienciavida.org

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10689. 14p.

DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility.

Autor: Pardini B; Italian Institute for Genomic Medicine (IIGM), Turin, Italy.; Department of Medical Sciences, University of Turin, Turin, Italy., Corrado A; Department of Biology, University of Pisa, Pisa, Italy., Paolicchi E; Department of Biology, University of Pisa, Pisa, Italy., Cugliari G; Italian Institute for Genomic Medicine (IIGM), Turin, Italy.; Department of Medical Sciences, University of Turin, Turin, Italy., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD., Bezieau S; Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU), Nantes, France., Bien SA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.; School of Public Health, University of Washington, Seattle, WA., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Caan BJ; Kaiser Permanente Medical Care Program of Northern California, Oakland, CA., Campbell PT; Epidemiology Research Program, American Cancer Society, Atlanta, GA., Casey G; Public Health Sciences, University of Virginia, Charlottesville, VA., Chan AT; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Cotterchio M; Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada., Gala M; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA., Gallinger SJ; Department of Surgery, Mount Sinai Hospital, Toronto, ON, Canada., Haile RW; Stanford University School of Medicine, Stanford, CA., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Hayes RB; Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hopper JL; Melbourne School of Population Health, The University of Melbourne, Melbourne, VIC, Australia., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Huyghe J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Jenkins MA; Melbourne School of Population Health, The University of Melbourne, Melbourne, VIC, Australia., Le Marchand L; Epidemiology Program, Research Cancer Center of Hawaii, University of Hawaii, Honolulu, HI., Lin Y; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Lindor NM; Department of Health Sciences Research, Mayo Clinic Arizona, Scottsdale, AZ., Nan H; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Ogino S; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA., Potter JD; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Schoen RE; Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA., Slattery ML; Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT., White E; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Vodickova L; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic., Vymetalkova V; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic., Vodicka P; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic., Gemignani F; Department of Biology, University of Pisa, Pisa, Italy., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Naccarati A; Italian Institute for Genomic Medicine (IIGM), Turin, Italy.; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic., Landi S; Department of Biology, University of Pisa, Pisa, Italy.

Publikováno v: International journal of cancer [Int J Cancer] 2020 Jan 15; Vol. 146 (2), pp. 363-372. Date of Electronic Publication: 2019 Jul 04.

KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges.

Autor: Li, Chang-Yun^1,2 (AUTHOR), Wang, Wanhe³ (AUTHOR), Leung, Chung-Hang^4,5,6,7 (AUTHOR) duncanleung@um.edu.mo, Yang, Guan-Jun^1,2 (AUTHOR) champion2014@126.com, Chen, Jiong^1,2 (AUTHOR) chenjiong@nbu.edu.cn

Publikováno v: Molecular Cancer. 5/20/2024, Vol. 23 Issue 1, p1-23. 23p.

Mesothelin promoter variants are associated with increased soluble mesothelin-related peptide levels in asbestos-exposed individuals.

Autor: De Santi C; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Pucci P; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Bonotti A; Preventive and Occupational Medicine, University Hospital of Pisa, Pisa, Italy., Melaiu O; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Cipollini M; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Silvestri R; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Vymetalkova V; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Praha, Czech Republic., Barone E; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Paolicchi E; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Corrado A; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Lepori I; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Dell'Anno I; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Pellè L; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Vodicka P; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Praha, Czech Republic., Mutti L; School of Environment and Life Sciences, University of Salford, Manchester, United Kingdom., Foddis R; Department of Translational Research and of new Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Cristaudo A; Department of Translational Research and of new Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Gemignani F; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy., Landi S; Department of Biology, University of Pisa, Via Derna 1, Pisa, Italy.

Publikováno v: Occupational and environmental medicine [Occup Environ Med] 2017 Jun; Vol. 74 (6), pp. 456-463. Date of Electronic Publication: 2017 Mar 25.