Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paola eSebastiani"'
Publikováno v:
Frontiers in Genetics, Vol 5 (2015)
Many genetic markers have been shown to be associated with common quantitative traits in genome-wide association studies. Typically these associated genetic markers have small to modest effect sizes and individually they explain only a small amount o
Externí odkaz:
https://doaj.org/article/51c3875f66894166a07cae3fdb521c14
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
Linear mixed models have become a popular tool to analyze continuous data from family-based designs by using random effects that model the correlation of subjects from the same family. However, mixed models for family data are challenging to implemen
Externí odkaz:
https://doaj.org/article/03c753f0f94148a7beabf00b6b20d2b7
Autor:
Paola eSebastiani, Fangui eSun, Stacy Lynn Andersen, Joseph eLee, Mary Kaye Wojczynski, Jason L Sanders, Anatoliy I Yashin, Anne B Newman, Thomas T Perls
Publikováno v:
Frontiers in Public Health, Vol 1 (2013)
Hypothesizing that members of families enriched for longevity delay morbidity compared to population controls and approximate the health-span of centenarians, we compared the health spans of older generation subjects of the Long Life Family Study (LL
Externí odkaz:
https://doaj.org/article/1c4d6ed2bbc747cf860d2abce0ce56ef
Autor:
Harold T Bae, Paola eSebastiani, Jenny X Sun, Stacy L Andersen, E Warwick Daw, Antonio eTerracciano, Luigi eFerrucci, Thomas T Perls
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on pe
Externí odkaz:
https://doaj.org/article/06e1071fa41d4d57bd9d1dbe067b3173
Autor:
Paola eSebastiani, Thomas T Perls
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
The New England Centenarian Study (NECS) was founded in 1994 as a longitudinal study of centenarians to determine if centenarians could be a model of healthy human aging. Over time, the NECS along with other centenarian studies have demonstrated that
Externí odkaz:
https://doaj.org/article/920a48e7bed14a0c81c03e13ee3d82c0
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
Genome-wide association studies (GWAS) have identified numerous associations between genetic loci and individual phenotypes; however, relatively few GWAS have attempted to detect pleiotropic associations, in which loci are simultaneously associated w
Externí odkaz:
https://doaj.org/article/136e7705f132446e91a89837ca43031c
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
One of the most popular modeling approaches to genetic risk prediction is to use a summary of risk alleles in the form of an unweighted or a weighted genetic risk score, with weights that relate to the odds for the phenotype in carriers of the indivi
Externí odkaz:
https://doaj.org/article/fcedda599ba44793835c066f28fe89cc
Autor:
Paola eSebastiani, Alberto eRiva, Monty eMontano, Phillip ePham, Ali eTorkamani, Eugene eScherba, Gary eBenson, Jacqueline N Milton, Clinton T Baldwin, Stacy eAndersen, Nicholas J Schork, Martin H Steinberg, Thomas T Perls
Publikováno v:
Frontiers in Genetics, Vol 2 (2012)
Supercentenarians (age 110+ years old) generally delay or escape age-related diseases and disability well beyond the age one hundred and this exceptional survival is likely to be influenced by a genetic predisposition that includes both common and ra
Externí odkaz:
https://doaj.org/article/92229e14cf3b434bb8dc53257682d732