Three-dimensional vascular microenvironment landscape in human glioblastoma

Autor: George P. Cribaro, Elena Saavedra-López, Leire Romarate, Izaskun Mitxitorena, Laura R. Díaz, Paola V. Casanova, Meritxell Roig-Martínez, José M. Gallego, Ana Perez-Vallés, Carlos Barcia

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)

Abstract The cellular complexity of glioblastoma microenvironments is still poorly understood. In-depth, cell-resolution tissue analyses of human material are rare but highly necessary to understand the biology of this deadly tumor. Here we present a

Externí odkaz: https://doaj.org/article/04b807eb0fb24bf1a04e9b3510abe8ef

Three-Dimensional Vascular Microenvironment Landscape in Human Glioblastoma

Autor: Paola V. Casanova, Ana Perez-Vallés, José M. Gallego, George P. Cribaro, Leire Romarate, Elena Saavedra-López, Izaskun Mitxitorena, Laura R. Díaz, Meritxell Roig-Martínez, Carlos Barcia

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)
Acta Neuropathologica Communications

The cellular complexity of glioblastoma microenvironments is still poorly understood. In-depth, cell-resolution tissue analyses of human material are rare but highly necessary to understand the biology of this deadly tumor. Here we present a unique 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f48a3a01400057dfe7e3710edb27f33
https://doi.org/10.2139/ssrn.3671739

Phagocytic glioblastoma-associated microglia and macrophages populate invading pseudopalisades

Autor: Meritxell Roig-Martínez, George P. Cribaro, Ana Perez-Vallés, Elena Saavedra-López, Paola V. Casanova, Carlos Barcia, José M. Gallego

Publikováno v: Brain Communications
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
instname

Hypoxic pseudopalisades are a pathological hallmark of human glioblastoma, which is linked to tumour malignancy and aggressiveness. Yet, their function and role in the tumour development have scarcely been explored. It is thought that pseudopalisades

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2786f02b1e7a0cbb030c04fd6ca2687
https://pubmed.ncbi.nlm.nih.gov/32954312

Imbalance of immunological synapse-kinapse states reflects tumor escape to immunity in glioblastoma

Autor: Laura R. Díaz, Elena Saavedra-López, Leire Romarate, Izaskun Mitxitorena, Paola V. Casanova, George P. Cribaro, José M. Gallego, Ana Pérez-Vallés, Jerónimo Forteza-Vila, Clara Alfaro-Cervello, José M. García-Verdugo, Carlos Barcia

Publikováno v: JCI Insight. 3

Since the proper activation of T cells requires the physical interaction with target cells through the formation of immunological synapses (IS), an alteration at this level could be a reason why tumors escape the immune response. As part of their lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4024e87dad66331ca029b5c2a20b078
https://doi.org/10.1172/jci.insight.120757

Studying the T Cell-Astrocyte Immune Synapse

Autor: Paola V. Casanova, Elena Saavedra-López, Carlos Barcia, George P. Cribaro, Laura Soler Rodríguez

Publikováno v: The Immune Synapse ISBN: 9781493968794

In this chapter, we describe the technical details to visualize and analyze effector immunological synapses between T cells and astrocytes in the brain with high-resolution confocal imaging. This procedure is critical for the optimal and even penetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41004c18896c2bd7598cee9bfe50ef88
https://doi.org/10.1007/978-1-4939-6881-7_32