Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paola Tocchetti"'
Autor:
Katie Zomorodi, Paola Tocchetti, Thomas C. Marbury, Elena Tudone, Jean Francois Marier, Mark Eller
Publikováno v:
Drug Design, Development and Therapy
Paola Tocchetti,1 Elena Tudone,2 Jean-Francois Marier,3 Thomas C Marbury,4 Katie Zomorodi,5 Mark Eller6 1Gentium, 2Clinical Operations, Gentium, Villa Guardia, Como, Italy; 3Reporting and Analysis Services, Pharsight, a Certara Company, Montreal, Que
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77287cb3eb82e1533ebe4cedfe1cecc
https://doi.org/10.2147/dddt.s112181
https://doi.org/10.2147/dddt.s112181
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 346(1)
Liver first-pass metabolism differs considerably among organic nitrates, but little information exists on the mechanism of denitration of these compounds in hepatic tissue. The metabolism of nitrooxybutyl-esters of flurbiprofen and ferulic-acid, a cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe14ed16df25d1bd80e61510ea8bf40d
https://pubmed.ncbi.nlm.nih.gov/23596058
https://pubmed.ncbi.nlm.nih.gov/23596058
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 317(2)
We investigated the in vitro metabolism of two (nitrooxy)butyl ester nitric oxide (NO) donor derivatives of flurbiprofen and ferulic acid, [1,1'-biphenyl]-4-acetic acid-2-fluoro-alpha-methyl-4-(nitrooxy)butyl ester (HCT 1026) and 3-(4-hydroxy-3-metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7e1b224d72c84d8281416b4b6ebe57
https://pubmed.ncbi.nlm.nih.gov/16424150
https://pubmed.ncbi.nlm.nih.gov/16424150
Publikováno v:
Cardiovascular drug reviews. 22(2)
Portal hypertension, a life threatening complication of liver cirrhosis, results from increased intrahepatic resistance and increased portal blood inflow through a hyperdynamic splanchnic system. The increased intrahepatic vascular tone is the result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942bac2e39a1f2641b3a735a5c86cedd
https://pubmed.ncbi.nlm.nih.gov/15179450
https://pubmed.ncbi.nlm.nih.gov/15179450
Autor:
Giancarlo Aldini, Marica Orioli, Marina Carini, Paola Tocchetti, Angela Piccoli, Roberto Maffei Facino
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 35(2)
The metabolic fate of nitric oxide (NO) released from nitroaspirin, benzoic acid, 2-(acetyloxy)-3-[(nitrooxy)methyl]phenyl ester (NCX 4016), the lead compound of a new class of NO-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ede4d36028553852b3b0726dc47f5
https://pubmed.ncbi.nlm.nih.gov/15063462
https://pubmed.ncbi.nlm.nih.gov/15063462
Autor:
E. Frigerio, Cinzia Pellizzoni, Maria Grazia Castelli, Paola Tocchetti, Philippe Dostert, Giannantonio Brianceschi, Margherita Strolin Benedetti
Publikováno v:
Chirality. 7(4)
Reboxetine, (RS)-2-[(RS)-α-(2-ethoxyphenoxy)benzyl]morpholine methanesulphonate, is a racemic compound and consists of a mixture of the (R,R)- and (S,S)-enantiomers. In this study, brain and plasma levels of both enantiomers were determined in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446b59505464bdfd5ad91eeef92a225e
https://pubmed.ncbi.nlm.nih.gov/7640172
https://pubmed.ncbi.nlm.nih.gov/7640172
Publikováno v:
Gastroenterology. 127:1019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c8697de8d9faca6e438d871472786f
https://doi.org/10.1053/j.gastro.2004.07.049
https://doi.org/10.1053/j.gastro.2004.07.049