Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB

Autor: Noemi A. Guadagno, Claudia Moriconi, Valerio Licursi, Emanuela D'Acunto, Paola S. Nisi, Nicoletta Carucci, Antonella De Jaco, Emanuele Cacci, Rodolfo Negri, Giuseppe Lupo, Elena Miranda

Publikováno v: Neurobiology of Disease, Vol 103, Iss , Pp 32-44 (2017)

The serpinopathies are human pathologies caused by mutations that promote polymerisation and intracellular deposition of proteins of the serpin superfamily, leading to a poorly understood cell toxicity. The dementia FENIB is caused by polymerisation

Externí odkaz: https://doaj.org/article/40f41ac322b146d2a0e0a47bb55bb048

Dbx2, an aging-related homeobox gene, inhibits the proliferation of adult neural progenitors

Autor: Andrea Giuliani, Valerio Licursi, Paola S. Nisi, Mario Fiore, Stefano Biagioni, Rodolfo Negri, Peter J. Rugg-Gunn, Emanuele Cacci, Giuseppe Lupo

The subventricular zone (SVZ) of the adult mouse brain contains quiescent neural stem cells, which can be activated (aNSCs) to generate transit amplifying progenitors (TAPs), neuroblasts (NBs) and newborn neurons. Neurogenesis declines during aging,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14a439d92b2aaf664021464431439ba4
https://doi.org/10.1101/2023.01.16.524218

X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics

Autor: Paola S. Nisi, M Fiore, Emanuele Cacci, Roberto Amendola, Rodolfo Negri, Nicoletta Carucci, Fiammetta Vernì, Serena Sineri, Valerio Licursi, Giulia Guarguaglini, Silvia Anzellotti, Stefano Biagioni, Enrico Cundari, Giuseppe Lupo, Jessica Favaro, Simone Pippa

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific reports (Nature Publishing Group) 10 (2020). doi:10.1038/s41598-020-63348-2
info:cnr-pdr/source/autori:Licursi, Valerio; Anzellotti, Silvia; Favaro, Jessica; Sineri, Serena; Carucci, Nicoletta; Cundari, Enrico; Fiore, Mario; Guarguaglini, Giulia; Pippa, Simone; Nisi, Paola S.; Vernì, Fiammetta; Biagioni, Stefano; Cacci, Emanuele; Amendola, Roberto; Lupo, Giuseppe; Negri, Rodolfo/titolo:X-ray irradiated cultures of mouse cortical neural stem%2Fprogenitor cells recover cell viability and proliferation with dose-dependent kinetics/doi:10.1038%2Fs41598-020-63348-2/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:10

Exposure of the developing or adult brain to ionizing radiation (IR) can cause cognitive impairment and/or brain cancer, by targeting neural stem/progenitor cells (NSPCs). IR effects on NSPCs include transient cell cycle arrest, permanent cell cycle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d74330506a1bbd7bcb59b3a38ad6f79
https://www.nature.com/articles/s41598-020-63348-2

Molecular Mechanisms of Neurogenic Aging in the Adult Mouse Subventricular Zone

Autor: Stefano Biagioni, Paola S. Nisi, Emanuele Cacci, Roberta Gioia, Giuseppe Lupo

Publikováno v: Journal of Experimental Neuroscience
Journal of Experimental Neuroscience, Vol 13 (2019)

In the adult rodent brain, the continuous production of new neurons by neural stem/progenitor cells (NSPCs) residing in specialized neurogenic niches and their subsequent integration into pre-existing cerebral circuitries supports odour discriminatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06711661b58fbfb6804c91b53fbbcf35
https://doi.org/10.1177/1179069519829040

Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline

Autor: Hai-Kun Liu, Paola Bovolenta, Ben Sidders, Stefano Biagioni, Yu-Lee Paul, Paola S. Nisi, Emanuele Cacci, Clara Lopes Novo, Peter J. Rugg-Gunn, Muhammad Amir Khan, Giuseppe Lupo, Pilar Esteve

Publikováno v: Aging Cell
Digital.CSIC. Repositorio Institucional del CSIC
instname

Adult neurogenesis declines with aging due to the depletion and functional impairment of neural stem/progenitor cells (NSPCs). An improved understanding of the underlying mechanisms that drive age-associated neurogenic deficiency could lead to the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0224298bc24c6836517ffea1d5dcc0b
https://doi.org/10.1111/acel.12745