Výsledky vyhledávání - "Paola Rovella"

RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo

Autor: Jessica Sebastiani, Michela Puxeddu, Marianna Nalli, Ruoli Bai, Ludovica Altieri, Paola Rovella, Eugenio Gaudio, Daniela Trisciuoglio, Filippo Spriano, Patrizia Lavia, Cinzia Fionda, Domiziana Masci, Andrea Urbani, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Francesco Bertoni, Romano Silvestri, Giuseppe La Regina

We synthesized a new inhibitor of tubulin polymerization, the pyrrole (1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrrol-3-yl)(3,4,5-trimethoxy-phenyl)methanone 6 (RS6077). Compound 6 inhibited the growth of multiple cancer cell lines, with IC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b627b1f33ba1c80296963a7e5f365b5c
https://hdl.handle.net/11573/1669754

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RS6077 Induces Mitotic Arrest and Selectively Activates Cell Death in Human Cancer Cell Lines and in a Lymphoma Tumor In Vivo

Autor: Jessica Sebastiani, Michela Puxeddu, Marianna Nalli, Ruoli Bai, Ludovica Altieri, Paola Rovella, Eugenio Gaudio, Daniela Trisciuoglio, Filippo Spriano, Patrizia Lavia, Cinzia Fionda, Ernest Hamel, Francesco Bertoni, Romano Silvestri, Giuseppe La Regina

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::424b85a9e4982c2adfc89b2dfbe9d9df
https://doi.org/10.2139/ssrn.4123438

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Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region

Autor: M. Eugenia Schininà, Laura Di Francesco, Patrizia Lavia, Paola Rovella, Annalisa Verrico, David Sasah Staid, Loredana Le Pera, Michela Damizia

Publikováno v: Oncogene (Basingstoke, Online) 39 (2019): 454–468. doi:10.1038/s41388-019-0989-x
info:cnr-pdr/source/autori:Verrico A.; Rovella P.; Di Francesco L.; Damizia M.; Staid D.S.; Le Pera L.; Schinina M.E.; Lavia P./titolo:Importin-beta%2Fkaryopherin-beta1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region/doi:10.1038%2Fs41388-019-0989-x/rivista:Oncogene (Basingstoke, Online)/anno:2019/pagina_da:454/pagina_a:468/intervallo_pagine:454–468/volume:39

The nuclear transport receptor importin-beta/karyopherin-beta1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. In addition to its role in nucleo-cytoplasmic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa478060e013dee4cb488c3e2d3f67d
https://doi.org/10.1038/s41388-019-0989-x

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Reverse transcriptase inhibitors promote the remodelling of nuclear architecture and induce autophagy in prostate cancer cells

Autor: Ilaria Sciamanna, Daniela Giovannini, Cristina Bellisai, Roberto Cirilli, Ciro Milite, Patrizia Lavia, Annalucia Serafino, Paola Sinibaldi-Vallebona, Mohammad Salik Zeya Ansari, Giusj Monia Pugliese, Paola Rovella, Mirko Baranzini, Pietro Pichierri, Corrado Spadafora, Daniela Trisciuoglio, Gianluca Sbardella

Publikováno v: Cancer letters
478 (2020): 133–145. doi:10.1016/j.canlet.2020.02.029
info:cnr-pdr/source/autori:Cristina Bellisaia, Ilaria Sciamanna, Paola Rovella, Daniela Giovannini, Mirko Baranzini, Giusj Monia Pugliese, Mohammad Salik Zeya Ansari, Ciro Milite, Paola Sinibaldi-Vallebona, Roberto Cirilli, Gianluca Sbardella, Pietro Pichierri, Daniela Trisciuoglio, Patrizia Lavia, Annalucia Serafino, Corrado Spadafora/titolo:Reverse transcriptase inhibitors promote the remodeling of nuclear architecture and induce autophagy in prostate cancer cells/doi:10.1016%2Fj.canlet.2020.02.029/rivista:Cancer letters (Print)/anno:2020/pagina_da:133/pagina_a:145/intervallo_pagine:133–145/volume:478

Emerging data indicate that the reverse transcriptase (RT) protein encoded by LINE-1 transposable elements is a promising cancer target. Nonnucleoside RT inhibitors, e.g. efavirenz (EFV) and SPV122.2, reduce proliferation and promote differentiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586777b6203f38b137d9724e4fa09f52
http://hdl.handle.net/11573/1490284

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New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors

Publikováno v: European journal of medicinal chemistry (Online) 152 (2018): 283–297. doi:10.1016/j.ejmech.2018.04.042
info:cnr-pdr/source/autori:La Regina G.; Bai R.; Coluccia A.; Naccarato V.; Famiglini V.; Nalli M.; Masci D.; Verrico A.; Rovella P.; Mazzoccoli C.; Da Pozzo E.; Cavallini C.; Martini C.; Vultaggio S.; Dondio G.; Varasi M.; Mercurio C.; Hamel E.; Lavia P.; Silvestri R./titolo:New 6-and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors/doi:10.1016%2Fj.ejmech.2018.04.042/rivista:European journal of medicinal chemistry (Online)/anno:2018/pagina_da:283/pagina_a:297/intervallo_pagine:283–297/volume:152

We designed new 3-arylthio- and 3-aroyl-1H-indole derivatives 3–22 bearing a heterocyclic ring at position 5, 6 or 7 of the indole nucleus. The 6- and 7-heterocyclyl-1H-indoles showed potent inhibition of tubulin polymerization, binding of colchici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1457acb63be3de3a836b37146c6566db
https://doi.org/10.1016/j.ejmech.2018.04.042

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Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays

Autor: Laura Di Francesco, Annalisa Verrico, Patrizia Lavia, Giulia Guarguaglini, Maria Eugenia Schininà, Italia Anna Asteriti, Paola Rovella, Pietro Cirigliano

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific reports (Nature Publishing Group) 8 (2018). doi:10.1038/s41598-018-19351-9
info:cnr-pdr/source/autori:Di Francesco, Laura; Verrico, Annalisa; Asteriti, Italia Anna; Rovella, Paola; Cirigliano, Pietro; Guarguaglini, Giulia; Schinina, Maria Eugenia; Lavia, Patrizia/titolo:Visualization of human karyopherin beta-1%2Fimportin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays/doi:10.1038%2Fs41598-018-19351-9/rivista:Scientific reports (Nature Publishing Group)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
Scientific Reports

Karyopherin beta-1/Importin beta-1 is a conserved nuclear transport receptor, acting in protein nuclear import in interphase and as a global regulator of mitosis. These pleiotropic functions reflect its ability to interact with, and regulate, differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecff06f5319c1b50b6b7ba343ae82c4c
http://link.springer.com/article/10.1038/s41598-018-19351-9

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Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules

Autor: Erica Di Cesare, Antonio Coluccia, Romano Silvestri, Patrizia Lavia, Annalisa Verrico, Andrea Miele, Maria Giubettini, Paola Rovella, Enrico Cundari, Valeria Famiglini, Giuseppe La Regina

Publikováno v: Oncotarget 8 (2017): 19738–19759. doi:10.18632/oncotarget.14980
info:cnr-pdr/source/autori:Di Cesare E.; Verrico A.; Miele A.; Giubettini M.; Rovella P.; Coluccia A.; Famiglini V.; La Regina G.; Cundari E.; Silvestri R.; Lavia P./titolo:Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules/doi:10.18632%2Foncotarget.14980/rivista:Oncotarget/anno:2017/pagina_da:19738/pagina_a:19759/intervallo_pagine:19738–19759/volume:8
Oncotarget

// Erica Di Cesare 1 , Annalisa Verrico 1 , Andrea Miele 1, 2 , Maria Giubettini 1, 3 , Paola Rovella 1 , Antonio Coluccia 4 , Valeria Famiglini 4 , Giuseppe La Regina 4 , Enrico Cundari 1 , Romano Silvestri 4 , Patrizia Lavia 1 1 Institute of Molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484b8534f44952d15a1abde9838fc576
http://hdl.handle.net/11573/935705

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Performance analysis of a rooftop, air-to-air heat pump working with CO2

Autor: Nicolandrea Calabrese, MASTRULLO, RITA MARIA ANTONIA, MAURO, ALFONSO WILLIAM, Paola Rovella, TAMMARO, MARCELLO

The air-conditioning sector for large buildings and shopping centers is developing a growing interest in rooftop heat pumps due to their easy installation. Instead of the application of HFC refrigerants, carbon dioxide (CO2) could be an interesting p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::045717e94346281c0a39662aa23b6c2f
http://hdl.handle.net/11588/608460

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Performance analysis of a rooftop, air-to-air heat pump working with CO2

Autor: Paola Rovella, Alfonso William Mauro, M. Tammaro, N. Calabrese, Rita Mastrullo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa9446db721162dde89cdef73dad8eb
http://www.scopus.com/inward/record.url?eid=2-s2.0-84921469522&partnerID=40&md5=b2b12505a0ac56552ba831bcca468582

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