Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Paola Portararo"'
Autor:
Barbara Bassani, Giorgia Simonetti, Valeria Cancila, Antonio Fiorino, Marilena Ciciarello, Annamaria Piva, Arman Mandegar Khorasani, Claudia Chiodoni, Daniele Lecis, Alessandro Gulino, Eugenio Fonzi, Laura Botti, Paola Portararo, Massimo Costanza, Marta Brambilla, Giorgia Colombo, Juerg Schwaller, Alexandar Tzankov, Maurilio Ponzoni, Fabio Ciceri, Niccolò Bolli, Antonio Curti, Claudio Tripodo, Mario P. Colombo, Sabina Sangaletti
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113794- (2024)
Summary: Acute myeloid leukemia (AML) progression is influenced by immune suppression induced by leukemia cells. ZEB1, a critical transcription factor in epithelial-to-mesenchymal transition, demonstrates immune regulatory functions in AML. Silencing
Externí odkaz:
https://doaj.org/article/da7ae959a4304ef9b858b1b572ed0a44
Autor:
Mario Paolo Colombo, Joe G N Garcia, Cristina Travelli, Giorgia Colombo, Martina Aliotta, Francesca Fagiani, Natalia Fava, Rita De Sanctis, Ambra A Grolla, Nausicaa Clemente, Paola Portararo, Massimo Costanza, Fabrizio Condorelli, Sabina Sangaletti, Armando A Genazzani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Nicotinamide phosphoribosyltransferase (NAMPT) is a key intracellular enzyme that participates in nicotinamide adenine dinucleotide (NAD) homeostasis as well as a released cytokine (eNAMPT) that is elevated in inflammatory conditions and i
Externí odkaz:
https://doaj.org/article/c682ddf856af461abc7e0fc0260b779f
Autor:
Claudio Tripodo, Barbara Bassani, Elena Jachetti, Valeria Cancila, Claudia Chiodoni, Paola Portararo, Laura Botti, Cesare Valenti, Milena Perrone, Maurilio Ponzoni, Patrizia Comoli, Mara Lecchi, Paolo Verderio, Antonio Curti, Mario P Colombo, Sabina Sangaletti
Publikováno v:
eLife, Vol 11 (2022)
Neutrophil extracellular traps (NETs) are web-like chromatin structures composed by dsDNA and histones, decorated with antimicrobial proteins. Their interaction with dendritic cells (DCs) allows DC activation and maturation toward presentation of NET
Externí odkaz:
https://doaj.org/article/a72a0e0c12714adaa226785d4975a485
Autor:
Sabina Sangaletti, Laura Botti, Alessandro Gulino, Daniele Lecis, Barbara Bassani, Paola Portararo, Matteo Milani, Valeria Cancila, Loris De Cecco, Matteo Dugo, Claudio Tripodo, Mario P. Colombo
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102510- (2021)
Summary: The secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein with unexpected immunosuppressive function in myeloid cells. We investigated the role of SPARC in autoimmunity using the pristane-induced model of lupus that
Externí odkaz:
https://doaj.org/article/5dbcfbcfcf15400b81ecad1e31918837
Autor:
Barbara Bassani, Claudio Tripodo, Paola Portararo, Alessandro Gulino, Laura Botti, Claudia Chiodoni, Elena Jachetti, Niccolò Bolli, Marilena Ciciarello, Korinna Joehrens, Ioannis Anagnostopoulos, Il-Kang Na, Antonio Curti, Mario P. Colombo, Sabina Sangaletti
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune reg
Externí odkaz:
https://doaj.org/article/e88362481b7d43daa9fe89b5cd444399
Autor:
Sabina Sangaletti, Fabio Iannelli, Federica Zanardi, Valeria Cancila, Paola Portararo, Laura Botti, Davide Vacca, Claudia Chiodoni, Arianna Di Napoli, Cesare Valenti, Celeste Rizzello, Maria Carmela Vegliante, Federica Pisati, Alessandro Gulino, Maurilio Ponzoni, Mario Paolo Colombo, Claudio Tripodo
Publikováno v:
EBioMedicine, Vol 61, Iss , Pp 103055- (2020)
Background: Intra-tumour heterogeneity in lymphoid malignancies encompasses selection of genetic events and epigenetic regulation of transcriptional programs. Clonal-related neoplastic cell populations are unsteadily subjected to immune editing and m
Externí odkaz:
https://doaj.org/article/662b10b597da49ab97d7a5c5e7f26f9e
Autor:
Sabina Sangaletti, Claudio Tripodo, Alessandra Santangelo, Nadia Castioni, Paola Portararo, Alessandro Gulino, Laura Botti, Mariella Parenza, Barbara Cappetti, Rosaria Orlandi, Elda Tagliabue, Claudia Chiodoni, Mario P. Colombo
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 233-248 (2016)
The extracellular matrix (ECM) contributes to the biological and clinical heterogeneity of breast cancer, and different prognostic groups can be identified according to specific ECM signatures. In high-grade, but not low-grade, tumors, an ECM signatu
Externí odkaz:
https://doaj.org/article/a912f2ea12794bedb22acf09ee8b7386
Autor:
Sabina Sangaletti, Giovanna Talarico, Claudia Chiodoni, Barbara Cappetti, Laura Botti, Paola Portararo, Alessandro Gulino, Francesca Maria Consonni, Antonio Sica, Giovanni Randon, Massimo Di Nicola, Claudio Tripodo, Mario P. Colombo
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge of their capacity to influence and adapt to the different tumor microenvironments and of the
Externí odkaz:
https://doaj.org/article/0713315082ce404b85fa8656bc18887e
Autor:
Mariangela Lecciso, Darina Ocadlikova, Sabina Sangaletti, Sara Trabanelli, Elena De Marchi, Elisa Orioli, Anna Pegoraro, Paola Portararo, Camilla Jandus, Andrea Bontadini, Annarita Redavid, Valentina Salvestrini, Pedro Romero, Mario P. Colombo, Francesco Di Virgilio, Michele Cavo, Elena Adinolfi, Antonio Curti
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Chemotherapy-induced immunogenic cell death can favor dendritic cell (DC) cross-priming of tumor-associated antigens for T cell activation thanks to the release of damage-associated molecular patterns, including ATP. Here, we tested the hypothesis th
Externí odkaz:
https://doaj.org/article/f87ab0dd0a8f4f79b935f68a291299ac
Autor:
Celia Cordero-Sanchez, Emanuela Pessolano, Beatrice Riva, Mauro Vismara, Silvia Maria Grazia Trivigno, Nausicaa Clemente, Silvio Aprile, Federico Alessandro Ruffinatti, Paola Portararo, Nicoletta Filigheddu, Ivan Zaggia, Irene P. Bhela, Marta Serafini, Tracey Pirali, Mario P. Colombo, Mauro Torti, Sabina Sangaletti, Alessandra Bertoni, Armando A. Genazzani
Publikováno v:
Blood Advances. 6:4471-4484
Store-operated Ca2+-entry is a cellular mechanism that governs the replenishment of intracellular stores of Ca2+ upon depletion caused by the opening of intracellular Ca2+-channels. Gain-of-function mutations of the 2 key proteins of store-operated C