Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Paola Piovesan"'
1
Design, Synthesis, and Structure–Activity Relationship of N-Arylnaphthylamine Derivatives as Amyloid Aggregation Inhibitors
Autor: Luca Pescatori, Orlando Ghirardi, Roberto Di Santo, Diana Celona, Giovanna Guiso, Federica Rosi, Fabrizio Giorgi, Roberta Costi, Mario Vertechy, Patrizia Minetti, Paola Piovesan, Luigi Scipione, Mauro Marzi, Giuliana Cuzzucoli Crucitti, Silvio Caccia
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (19), pp.8538-48. ⟨10.1021/jm301105m⟩
International audience; Dyes like CR are able to inhibit the aggregation of Aβ fibrils. Thus, a screening of a series of dyes including ABBB (1) was performed. Its main component 2 tested in an in vitro assay (i.e., ThT assay) showed good potency at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6070b3b53fd6a813e85dee66b31b890d
https://doi.org/10.1021/jm301105m
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2
ST1859 reduces prion infectivity and increase survival in experimental scrapie
Autor: Orlando Ghirardi, Laura Colombo, Mario Salmona, Paola Piovesan, Gianluigi Forloni
Publikováno v: Archives of Virology. 154:1539-1544
On the basis of the structural homologies between ST1859 (1[(2-hydroxy-1-naphtyl)methyl]-2-naphthol) and the anti-prion agents and its anti-amyloidogenic activity, we tested whether this molecule altered the biochemical properties of aggregates forme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c212eea5d0a7679d82f8f4e0d8fd7840
https://doi.org/10.1007/s00705-009-0471-0
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3
Immunogenic, antigenic, fibrillogenic and inflammatory properties of new simplified β-amyloid peptides
Autor: Antonio Verdoliva, Maurizio Colombo, Franco Borsini, Maria Rossi, Luca Battistini, Debora Capobianco, Maria Teresa Cencioni, Domenico Mastroianni, Orlando Ghirardi, Valentina Bombardi, Paola Piovesan
Publikováno v: Molecular Immunology. 46:2524-2532
The most promising approach in Alzheimer disease immunotherapy is represented by amyloid beta derivatives with low intrinsic neurotoxicity and minimal overall T cell responses. To avoid toxicity and autoimmune response, we have designed a new class o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f0b5ce18be06e40a010bf58f51e570
https://doi.org/10.1016/j.molimm.2009.05.017
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4
Acetyl-l-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection
Autor: Paola Piovesan, Giulio Taglialatela, Luciano Angelucci, M.T. Ramacci, Licia Pacifici
Publikováno v: Brain Research. 633:77-82
Transection of the fimbria-fornix in adult rats is a useful model for producing impairments of cholinergic activity in the hippocampus (HIPP) and atrophy of the medial septum cholinergic perikarya, similar to those observed during senescence, that ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643a6854b89d1d18d6443f5581377d69
https://doi.org/10.1016/0006-8993(94)91524-5
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5
2-Aminotetraline derivative protects from ischemia/reperfusion brain injury with a broad therapeutic window
Autor: Patrizia Marzorati, Carmen Capone, Cinzia Fabrizi, Paola Piovesan, Maria Grazia De Simoni, Lorenzo Fumagalli, Orlando Ghirardi, Maria Cristina Principato, Paolo Carminati
The effect of ST1942, a 2-aminotetraline derivative with anti-inflammatory properties, was evaluated in ischemia/reperfusion injury in CD1 and C57BL/6 mice. ST1942 or saline were injected intraperitoneally 30 min and 6, 24, 36 h after ischemia. Forty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7140ed5eedb375d18231c0450ba142
http://hdl.handle.net/11573/238421
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6
A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer's disease
Autor: Rupert Lanzenberger, Oliver Langer, Paola Piovesan, Andrea Hofmann, Mario E. Corrado, Kurt Kletter, Aiman Abrahim, Markus Müller, Martin Bauer, Eduard Auff, Peter Dal-Bianco, Christian Joukhadar, Rudolf Karch, Robert Dudczak, Orlando Ghirardi, Nadège Lods, Paolo Carminati, Martin Brunner, Gianluigi Forloni
Publikováno v: Clinical pharmacology and therapeutics. 80(3)
This work describes a microdosing study with an investigational, carbon 11-labeled antiamyloid drug, 1,1'-methylene-di-(2-naphthol) (ST1859), and positron emission tomography (PET) in healthy volunteers (n = 3) and patients with Alzheimer's disease (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7df54a7dd7cc914bb58b255537ccc1
https://pubmed.ncbi.nlm.nih.gov/16952488
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7
In vivo and in vitro cytokine modulatory activity of newly synthesised 2-aminotetraline derivatives
Autor: Cinzia Fabrizi, Claudio Albertoni, Eleonora Nucera, Silvia Campo, Paola Piovesan, Orlando Ghirardi, Vito Ruggiero, Paolo Carminati, Giuliana M. Lauro
In the present study, the protective effect of newly synthesised 2-aminotetralines was investigated in murine models of toxic shock. A few derivatives protected mice against lethality induced by lipopolysaccharide from different bacterial strains and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf23b444d208ac7b3544866c2db8ff7
https://hdl.handle.net/11590/269296
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8
Acetyl-L-carnitine restores choline acetyltransferase activity in the hippocampus of rats with partial unilateral fimbria-fornix transection
Autor: Giulio Taglialatela, Luciano Angelucci, Gianni Quatrini, Licia Pacifici, Paola Piovesan
Publikováno v: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 13(1)
Transection of the fimbria-fornix bundle in adult rats results in degeneration of the septo-hippocampal cholinergic pathway, reminiscent of that occurring in aging as well as Alzheimer disease. We report here a study of the effect of a treatment with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ede20c8bd8d8534ed97c26d08f9621f
https://pubmed.ncbi.nlm.nih.gov/7793306
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10
Severity of early separation and later abusive mothering in monkeys: what is the pathogenic threshold?
Autor: Paola Piovesan, Filippo Aureli, Francesca R. D'Amato, Alfonso Troisi
Publikováno v: Scopus-Elsevier
This study reports on a nonexperimentally induced case of infant abuse by a macaque mother living in a stable social group. The case is of particular interest because of the early experience of the abusive mother: she had been abandoned right after b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d915c9863c4caee5ba0d76af192b7430
https://pubmed.ncbi.nlm.nih.gov/2708466
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