Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Paola Perrotta"'
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Akademický článek
Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice
Autor: Victoria Ulrich, Noemi Rotllan, Elisa Araldi, Amelia Luciano, Philipp Skroblin, Mélanie Abonnenc, Paola Perrotta, Xiaoke Yin, Ashley Bauer, Kristen L Leslie, Pei Zhang, Binod Aryal, Rusty L Montgomery, Thomas Thum, Kathleen Martin, Yajaira Suarez, Manuel Mayr, Carlos Fernandez‐Hernando, William C Sessa
Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 6, Pp 643-653 (2016)
Abstract Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chron
Externí odkaz: https://doaj.org/article/dfae49429d474f239ee09a30e0002d2d
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2
PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting
Autor: Paola Perrotta, Margreet R. de Vries, Pieter-Jan Guns, Bart Peeters, Wim Martinet, Guido R.Y. De Meyer, Paul H.A. Quax
Publikováno v: Angiogenesis
Angiogenesis, 25, 129-143. SPRINGER
Vein grafting is a frequently used surgical intervention for cardiac revascularization. However, vein grafts display regions with intraplaque (IP) angiogenesis, which promotes atherogenesis and formation of unstable plaques. Graft neovessels are main
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b041fa67c84ddd69dc86f25bd691152f
https://doi.org/10.1007/s10456-021-09816-3
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3
Three-Dimensional Imaging of Intraplaque Neovascularization in a Mouse Model of Advanced Atherosclerosis
Autor: Paul H.A. Quax, Jean-Pierre Timmermans, Isabel Pintelon, Wim Martinet, Margreet R. de Vries, Paola Perrotta, Guido R.Y. De Meyer
Publikováno v: Journal of Vascular Research, 57(6), 348-354. KARGER
Journal of vascular research
J Vasc Res.
Multiple lines of evidence suggest that intraplaque (IP) neovascularization promotes atherosclerotic plaque growth, destabilization, and rupture. However, pharmacological inhibition of IP neovascularization remains largely unexplored due to the limit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589ea67cecf96e244bc858bc6482ce23
https://doi.org/10.1159/000508449
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5
[18F]ZCDD083
Autor: Sergio Dall'Angelo, Carlo De Dominicis, Leonie Wyffels, Steven Staelens, Matteo Zanda, Paola Perrotta, G.R.Y. De Meyer
Publikováno v: ACS medicinal chemistry letters 11 (2020): 933–939. doi:10.1021/acsmedchemlett.9b00677
info:cnr-pdr/source/autori:De Dominicis, Carlo; Perrotta, Paola; Dall'Angelo, Sergio; Wyffels, Leonie; Staelens, Steven; De Meyer, G. R. Y.; Zanda, Matteo/titolo:[F-18]ZCDD083: A PFKFB3-Targeted PET Tracer for Atherosclerotic Plaque Imaging/doi:10.1021%2Facsmedchemlett.9b00677/rivista:ACS medicinal chemistry letters/anno:2020/pagina_da:933/pagina_a:939/intervallo_pagine:933–939/volume:11
ACS Medicinal Chemistry Letters
ACS Med Chem Lett
PFKFB3, a glycolysis-related enzyme upregulated in inflammatory conditions and angiogenesis, is an emerging target for diagnosis and therapy of atherosclerosis. The fluorinated phenoxindazole [18F]ZCDD083was synthesized, radiolabeled in 17 ± 5% radi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e59d1aa9ae8a60a34f51f2067dc48cb
https://hdl.handle.net/1887/3626979
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6
Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling
Autor: Sameet Mehta, Carlos Fernández-Hernando, William C. Sessa, Xinbo Zhang, Han Zhou, Swayam Prakash Srivastava, Ahmad F. Hedayat, Kariona A. Grabińska, Paola Perrotta, Chris Wong, Julie E. Goodwin
Vascular inflammation is present in many cardiovascular diseases, and exogenous glucocorticoids have traditionally been used as a therapy to suppress inflammation. However, recent data have shown that endogenous glucocorticoids, acting through the en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431d04cedd2650b46a24292f9c9552e5
https://europepmc.org/articles/PMC7098785/
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9
Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice
Autor: Mélanie Abonnenc, Pei Zhang, Victoria Ulrich, Yajaira Suárez, Kathleen A. Martin, Rusty L. Montgomery, Paola Perrotta, Thomas Thum, Kristen L. Leslie, Elisa Araldi, Philipp Skroblin, Amelia K. Luciano, Noemi Rotllan, Carlos Fernández-Hernando, William C. Sessa, Ashley J. Bauer, Manuel Mayr, Xiaoke Yin, Binod Aryal
Publikováno v: EMBO Molecular Medicine
Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chronic admini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5f2b34b7e6f6000d83b29fb3aef1b5
http://europepmc.org/articles/PMC4888854
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10
Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis
Autor: Lynn Roth, Paola Perrotta, Guido R.Y. De Meyer, Besa Emini Veseli, Wim Martinet, Bieke Van der Veken
Publikováno v: Vascular Pharmacology
Vascular pharmacology
Atherosclerosis is a complex multifactorial disease that affects large and medium-sized arteries. Rupture of atherosclerotic plaques and subsequent acute cardiovascular complications remain a leading cause of death and morbidity in the Western world.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55df1ac7abc30059e1c5f9d54642df89
https://pubmed.ncbi.nlm.nih.gov/29933080
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