Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Paola Ostano"'
Autor:
Soumitra Ghosh, Jovan Isma, Paola Ostano, Luigi Mazzeo, Annagiada Toniolo, Monalisa Das, Joni R. White, Christian Simon, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Alterations in nuclear structure and function are hallmarks of cancer cells. Little is known about these changes in Cancer-Associated Fibroblasts (CAFs), crucial components of the tumor microenvironment. Loss of the androgen receptor (AR) in
Externí odkaz:
https://doaj.org/article/ecacd5c27cbc40799626a289a8be3460
Autor:
Giulia Lori, Mirella Pastore, Nadia Navari, Benedetta Piombanti, Richell Booijink, Elisabetta Rovida, Ignazia Tusa, Monika Lewinska, Jesper B. Andersen, Tiziano Lottini, Annarosa Arcangeli, Maria Letizia Taddei, Erica Pranzini, Caterina Mancini, Cecilia Anceschi, Stefania Madiai, Elena Sacco, Stefano Rota, Adriana Trapani, Gennaro Agrimi, Matteo Ramazzotti, Paola Ostano, Caterina Peraldo Neia, Matteo Parri, Fabrizia Carli, Silvia Sabatini, Amalia Gastaldelli, Fabio Marra, Chiara Raggi
Publikováno v:
JHEP Reports, Vol 6, Iss 10, Pp 101182- (2024)
Background & Aims: Among the reprogrammed metabolic pathways described in cancer stem cells, aberrant lipid metabolism has recently drawn increasing attention. Our study explored the contribution of fatty acids (FA) in the regulation of stem-like fea
Externí odkaz:
https://doaj.org/article/0e4e35c1e77e4d688cf832f371555c98
Autor:
Luigi Mazzeo, Soumitra Ghosh, Emery Di Cicco, Jovan Isma, Daniele Tavernari, Anastasia Samarkina, Paola Ostano, Markus K. Youssef, Christian Simon, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract There are significant commonalities among several pathologies involving fibroblasts, ranging from auto-immune diseases to fibrosis and cancer. Early steps in cancer development and progression are closely linked to fibroblast senescence and
Externí odkaz:
https://doaj.org/article/339b32207a2241b58a145018d8854d9d
Autor:
Anastasia Samarkina, Markus Kirolos Youssef, Paola Ostano, Soumitra Ghosh, Min Ma, Beatrice Tassone, Tatiana Proust, Giovanna Chiorino, Mitchell P. Levesque, Sandro Goruppi, Gian Paolo Dotto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Melanoma provides a primary benchmark for targeted drug therapy. Most melanomas with BRAFV600 mutations regress in response to BRAF/MEK inhibitors (BRAFi/MEKi). However, nearly all relapse within the first two years, and there is a connectio
Externí odkaz:
https://doaj.org/article/c3125598e94f431c92edea912b20ab71
Autor:
Giovanna Chiorino, Elisabetta Petracci, Emir Sehovic, Ilaria Gregnanin, Elisa Camussi, Maurizia Mello-Grand, Paola Ostano, Emilia Riggi, Viviana Vergini, Alessia Russo, Enrico Berrino, Andrea Ortale, Francesca Garena, Tiziana Venesio, Federica Gallo, Elisabetta Favettini, Alfonso Frigerio, Giuseppe Matullo, Nereo Segnan, Livia Giordano
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Mammographic breast cancer screening is effective in reducing breast cancer mortality. Nevertheless, several limitations are known. Therefore, developing an alternative or complementary non-invasive tool capable of increasing the accuracy of
Externí odkaz:
https://doaj.org/article/044deb74a3a04e07afe4fafc799eea7d
Autor:
Chiara Arrigoni, Paola Ostano, Simone Bersini, Martina Crippa, Maria Vittoria Colombo, Mara Gilardi, Luigi Zagra, Maurizia Mello-Grand, Ilaria Gregnanin, Carmen Ghilardi, Maria Rosa Bani, Christian Candrian, Giovanna Chiorino, Matteo Moretti
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Angiogenic analysis and transcriptomics on bone and skeletal muscle endothelial cells from osteoarthritis patients reveal different inflammatory conditions have a different impact on these cell populations.
Externí odkaz:
https://doaj.org/article/92b46ef009ce4dd18c571b23a3075b35
Autor:
Laila Akhouayri, Paola Ostano, Maurizia Mello-Grand, Ilaria Gregnanin, Francesca Crivelli, Sara Laurora, Daniele Liscia, Francesco Leone, Angela Santoro, Antonino Mulè, Donatella Guarino, Claudia Maggiore, Angela Carlino, Stefano Magno, Maria Scatolini, Alba Di Leone, Riccardo Masetti, Giovanna Chiorino
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-17 (2022)
Abstract Background Triple-negative breast cancer (TNBC) is a very heterogeneous disease. Several gene expression and mutation profiling approaches were used to classify it, and all converged to the identification of distinct molecular subtypes, with
Externí odkaz:
https://doaj.org/article/fce1364bc95e48129fe63fabaf1063c5
Autor:
Francesca Bizzaro, Ilaria Fuso Nerini, Molly A. Taylor, Alessia Anastasia, Massimo Russo, Giovanna Damia, Federica Guffanti, Francesca Guana, Paola Ostano, Lucia Minoli, Maureen M. Hattersley, Stephanie Arnold, Antonio Ramos-Montoya, Stuart C. Williamson, Alessandro Galbiati, Jelena Urosevic, Elisabetta Leo, Ugo Cavallaro, Carmen Ghilardi, Simon T. Barry, Maria Rosa Bani, Raffaella Giavazzi
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Poly ADP-ribose polymerase inhibitors (PARPi) have transformed ovarian cancer (OC) treatment, primarily for tumours deficient in homologous recombination repair. Combining VEGF-signalling inhibitors with PARPi has enhanced clinical benefit i
Externí odkaz:
https://doaj.org/article/5d13984571584daaa1864d9ef2ed329a
Autor:
Atul Katarkar, Giulia Bottoni, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Francesca Lazzaroni, Ilaria Gregnanin, Paola Ostano, Victor Neel, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The presence of genomic alterations in cancer associated fibroblasts (CAFs) is largely unexplored. The authors show that frequent NOTCH1 gene amplification and overexpression render CAFs resistant to the UVA-induced DNA damage response (DDR) and prom
Externí odkaz:
https://doaj.org/article/50d8fbca5759425c9fb107d5441047f8
Autor:
Roberta Sulsenti, Barbara Frossi, Lucia Bongiovanni, Valeria Cancila, Paola Ostano, Irene Fischetti, Claudia Enriquez, Francesca Guana, Giovanna Chiorino, Claudio Tripodo, Carlo E. Pucillo, Mario P. Colombo, Elena Jachetti
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A relevant fraction of castration-resistant prostate cancers (CRPC) evolve into fatal neuroendocrine (NEPC) tumors in resistance to androgen deprivation and/or inhibitors of androgen receptor pathway. Therefore, effective drugs against both CRPC and
Externí odkaz:
https://doaj.org/article/0e01c40f4e1447ddb6c588360cb31915