Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Paola Munoz-Tello"'
Autor:
Jinsai Shang, Richard Brust, Sarah A Mosure, Jared Bass, Paola Munoz-Tello, Hua Lin, Travis S Hughes, Miru Tang, Qingfeng Ge, Theodore M Kamenekca, Douglas J Kojetin
Publikováno v:
eLife, Vol 7 (2018)
Crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) have revealed overlapping binding modes for synthetic and natural/endogenous ligands, indicating competition for the orthosteric pocket. Here we show that cobinding of a
Externí odkaz:
https://doaj.org/article/a02167cd994848e18bdd02c3743d1314
Autor:
Dilani G. Gamage, Kamran Melikov, Paola Munoz-Tello, Tanner J. Wherley, Leah C. Focke, Evgenia Leikina, Elliana Huffman, Jiajie Diao, Douglas J. Kojetin, Vikram Prasad, Leonid V. Chernomordik, Douglas P. Millay
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Muscle cell fusion is a multistep process where the final step of the reaction drives progression beyond early hemifusion events to complete fusion. This step requires activity of the muscle-specific fusogen Myomerger, a single-pass transmembrane pro
Autor:
Sarah A. Mosure, Paola Munoz-Tello, Kuang-Ting Kuo, Brian MacTavish, Xiaoyu Yu, Daniel Scholl, Christopher C. Williams, Timothy S. Strutzenberg, Jared Bass, Richard Brust, Ashok A. Deniz, Patrick R. Griffin, Douglas J. Kojetin
PPARγ is a nuclear receptor transcription factor that regulates adipogenic and insulin sensitizing gene programs via two activation function (AF) regulatory domains: a ligand-dependent AF-2 coregulator interaction surface within the C-terminal ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1391d8be19b46ea8fd2251bbc5a88fd
https://doi.org/10.1101/2022.07.13.499031
https://doi.org/10.1101/2022.07.13.499031
Autor:
Pasha Khan, Hua Lin, Theodore M. Kamenecka, Ian Mitchelle S. de Vera, Paola Munoz-Tello, Douglas J. Kojetin
Publikováno v:
Journal of Medicinal Chemistry. 64:5216-5220
Autor:
Douglas J. Kojetin, Paola Munoz-Tello, Pasha Khan, Theodore M. Kamenecka, Ian Mitchelle S. de Vera, Hua Lin
Publikováno v:
J Med Chem
Nurr1/NR4A2 is an orphan nuclear receptor transcription factor implicated as a drug target for neurological disorders including Alzheimer's and Parkinson's diseases. Previous studies identified small-molecule NR4A nuclear receptor modulators, but it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2adb4a43a6c3c2106202623fa2ed759
https://europepmc.org/articles/PMC8006468/
https://europepmc.org/articles/PMC8006468/
Autor:
Theodore M. Kamenecka, Paola Munoz-Tello, Pasha Khan, Douglas J. Kojetin, Hua Lin, Ian Mitchelle S. de Vera
Nurr1/NR4A2 is an orphan nuclear receptor transcription factor implicated as a potential drug target for neurological disorders including Alzheimer’s and Parkinson’s diseases. Previous studies identified small molecule modulators of NR4A nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a2015147e5a48b0a4aead0b77f8e416
https://doi.org/10.1101/2020.05.22.109017
https://doi.org/10.1101/2020.05.22.109017
Autor:
Sarah A. Mosure, Jinsai Shang, Douglas J. Kojetin, Paola Munoz-Tello, Patrick R. Griffin, Laura A. Solt, Timothy S. Strutzenberg
Publikováno v:
Science Advances
Structural and biochemical evidence resolves previous contradictory findings for heme-dependent NCoR recruitment to REV-ERBβ.
Heme is the endogenous ligand for the constitutively repressive REV-ERB nuclear receptors, REV-ERBα (NR1D1) and REV-E
Heme is the endogenous ligand for the constitutively repressive REV-ERB nuclear receptors, REV-ERBα (NR1D1) and REV-E
Autor:
Travis S. Hughes, Miru Tang, Qingfeng Ge, Theodore M Kamenekca, Paola Munoz-Tello, Jared Bass, Douglas J. Kojetin, Richard Brust, Hua Lin, Jinsai Shang, Sarah A. Mosure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f72f591dab4f8e1094100f37265f6db
https://doi.org/10.7554/elife.43320.077
https://doi.org/10.7554/elife.43320.077
Autor:
Mark Rance, Edna Matta-Camacho, Paola Munoz-Tello, Patrick R. Griffin, Pankaj Kumar Giri, Jie Zheng, Ian Mitchelle S. de Vera, Travis S. Hughes, Jinsai Shang, Douglas J. Kojetin, Venkatasubramanian Dharmarajan, David Marciano
Nuclear receptor-related 1 protein (Nurr1/NR4A2) is an orphan nuclear receptor (NR) that is considered to function without a canonical ligand-binding pocket (LBP). A crystal structure of the Nurr1 ligand-binding domain (LBD) revealed no physical spac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db2b8f8f371df4d5c36ec60ee12f052
https://europepmc.org/articles/PMC6318021/
https://europepmc.org/articles/PMC6318021/
Autor:
Juan Granados, Douglas J. Kojetin, Jinsai Shang, Ian Mitchelle S. de Vera, Pankaj Kumar Giri, Sean Campbell, Jakob Fuhrmann, William J. Gardner, Laura A. Solt, Richard Brust, Edna Matta-Camacho, Paola Munoz-Tello, Henry D. Wilson, Trevor P. Creamer
Publikováno v:
ACS Chemical Biology. 11:1795-1799
Nurr1/NR4A2 is an orphan nuclear receptor, and currently there are no known natural ligands that bind Nurr1. A recent metabolomics study identified unsaturated fatty acids, including arachidonic acid and docosahexaenoic acid (DHA), that interact with